Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: Roles of the peripheral vasopressin and central cholinergic systems

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dc.contributor.buuauthorÇam, Betül Etöz
dc.contributor.buuauthorİşbil, Naciye Büyükcoşkun
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-1692-2021tr_TR
dc.contributor.scopusid24179406800tr_TR
dc.contributor.scopusid55665951400tr_TR
dc.contributor.scopusid6602676331tr_TR
dc.date.accessioned2022-05-25T08:36:23Z
dc.date.available2022-05-25T08:36:23Z
dc.date.issued2012-03
dc.description.abstractOur objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V-1 receptors or the central cholinergic system play roles in these cardiovascular effects. Blood pressure and HR were observed before and for 30 min following drug injections. The following results were obtained: 1) icv ADM (750 ng/10 mu L) caused an increase in both blood pressure and HR (Delta MAP = 11.8 +/- 2.3 mmHg and Delta HR = 39.7 +/- 4.8 bpm). 2) Pretreatment with a CGRP receptor antagonist (CGRP(8-37)) and ADM receptor antagonist (ADM(22-52)) blocked the effect of central ADM on blood pressure and HR. 3) The nicotinic receptor antagonist mecamylamine (25 mu g/10 mu L, icv) and the muscarinic receptor antagonist atropine (5 mu g/10 mu L, icv) prevented the stimulating effect of ADM on blood pressure. The effect of ADM on HR was blocked only by atropine (5 mu g/10 mu L, icv). 4) The V-1 receptor antagonist [beta-mercapto-beta-beta-cyclopentamethylenepropionyl(1), O-me-Tyr(2),Arg(8)]-vasopressin (V2255; 10 mu g/kg), that was applied intravenously, prevented the effect of ADM on blood pressure and HR. This is the first study reporting the role of specific ADM and CGRP receptors, especially the role of nicotinic and muscarinic central cholinergic receptors and the role of peripheral V-1 receptors in the increasing effects of icv ADM on blood pressure and HR.en_US
dc.identifier.citationÇam, E. B. vd. (2012). "Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: Roles of the peripheral vasopressin and central cholinergic systems". Brazilian Journal of Medical and Biological Research, 45(3), 250-255.en_US
dc.identifier.endpage255tr_TR
dc.identifier.issn0100-879X
dc.identifier.issn1414-431X
dc.identifier.issue3tr_TR
dc.identifier.pubmed22370705tr_TR
dc.identifier.scopus2-s2.0-84858427547tr_TR
dc.identifier.startpage250tr_TR
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2012007500027
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854196/
dc.identifier.urihttp://hdl.handle.net/11452/26682
dc.identifier.volume45tr_TR
dc.identifier.wos000302556400011tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.journalBrazilian Journal of Medical and Biological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitakSBAG-105S508tr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLife sciences & biomedicine - other topicsen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectAdrenomedullinen_US
dc.subjectBlood pressureen_US
dc.subjectVasopressinen_US
dc.subjectAtropineen_US
dc.subjectMecamylamineen_US
dc.subjectNervous-systemen_US
dc.subjectBlood-pressureen_US
dc.subjectReceptorsen_US
dc.subjectMechanismsen_US
dc.subjectPeptideen_US
dc.subjectBrainen_US
dc.subjectImmunoreactivityen_US
dc.subjectAcetylcholineen_US
dc.subjectInvolvementen_US
dc.subjectParametersen_US
dc.subjectRattusen_US
dc.subject.emtree(Beta mercapto beta beta cyclopentamethylenepropionyl1, o me tyrosine2,arginine8)vasopressinen_US
dc.subject.emtreeAdrenomedullinen_US
dc.subject.emtreeAdrenomedullin[22-52]en_US
dc.subject.emtreeAtropineen_US
dc.subject.emtreeCalcitonin gene related peptide receptoren_US
dc.subject.emtreeCalcitonin gene related peptide receptor antagonisten_US
dc.subject.emtreeCalcitonin gene related peptide receptor[8-37]en_US
dc.subject.emtreeMecamylamineen_US
dc.subject.emtreeMuscarinic receptoren_US
dc.subject.emtreeNicotinic receptoren_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeVasopressin derivativeen_US
dc.subject.emtreeVasopressin v1 receptoren_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood pressure regulationen_US
dc.subject.emtreeCardiovascular responseen_US
dc.subject.emtreeCholinergic stimulationen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeDrug receptor bindingen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeReceptor blockingen_US
dc.subject.scopusAdrenomedullin Receptors; Receptor Activity-Modifying Proteins; Calcitonin Receptor Like Receptoren_US
dc.subject.wosBiologyen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.titleCardiovascular effects of the intracerebroventricular injection of adrenomedullin: Roles of the peripheral vasopressin and central cholinergic systemsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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