Relaps gösteren ve/veya refrakter erişkin akut lösemi olgularında mitoksantron'un tek ajan olarak kullanılması
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Date
1993-09-22
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Publisher
Uludağ Üniversitesi
Abstract
Günümüzde halen relaps gösteren ve/veya refrakter erişkin akut lösemi olguları ile blastik dönüşüm gösteren KML olgularında (KML-B2) prognozu iyileştirecek yeni tedavi imkanları araştırılmaktadır. Tek ajan olarak mitoksantronun 12 mg/m-/gün IV 1-5 gün uygulanması ile bu hastaların tedavisinde umut verici sonuçlar alındığı bildirilmiştir. Biz de bu tedavinin klinik etkinliğini araştırmak amacıyla 4'ü ALL, 2'si ANLL ve 2'si KML-B olmak üzere toplam 8 refrakter olguda tek başına mitoksantron uyguladık. 1 olgu indüksiyon sırasında kaybedildi, 1 olgu cevapsız kaldı, 6 olguda 3-7 günlerde belirginleşen lökopeni gelişti. Bu 6 olgudan 3'ünde 3 haftayı aşan miyelosupresyon oluştu . Tedavi hastalar tarafından çok iyi tolere edildi. Herhangi bir kardiak, hepatik ya da renal yan etki saptanmadı.
Research are ongoing in recent days for achieving better prognosis for refractory and/or relapsed acute leukemia cases and CML cases with blastic transformation (KML-B). In recent reports promising results are reported for the therapy of these patients using mitoxantrone 12 mg/m2/day IV 1- 5 days as a single agent. In order to test the clinical efficacy of this therapy we performed mitoxantrone as a single agent in 8 refractory cases (4 ALL, 2 ANLL, 2 CML-B). 1 case was died white induction, 1 case had no answer the therapy. In 6 cases leukopenia has been seen in 3-7 days. 3 of these 6 patients there has been a myelosuppression more than 3 weeks. Therapy is well tolerated by the patients. No hepatic, renal or cardiac side effect has been determined.
Research are ongoing in recent days for achieving better prognosis for refractory and/or relapsed acute leukemia cases and CML cases with blastic transformation (KML-B). In recent reports promising results are reported for the therapy of these patients using mitoxantrone 12 mg/m2/day IV 1- 5 days as a single agent. In order to test the clinical efficacy of this therapy we performed mitoxantrone as a single agent in 8 refractory cases (4 ALL, 2 ANLL, 2 CML-B). 1 case was died white induction, 1 case had no answer the therapy. In 6 cases leukopenia has been seen in 3-7 days. 3 of these 6 patients there has been a myelosuppression more than 3 weeks. Therapy is well tolerated by the patients. No hepatic, renal or cardiac side effect has been determined.
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Keywords
Akut lösemi, Mitoksantron, Acute leukemia, Mitoxantrone
Citation
Manavoğlu, O. vd. (1993). ''Relaps gösteren ve/veya refrakter erişkin akut lösemi olgularında mitoksantron'un tek ajan olarak kullanılması''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 20(2), 183-186.