Kobaylarda deriye uygulanan sodyum benzoatın sistemik etkileri
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Date
1995-11-29
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Publisher
Uludağ Üniversitesi
Abstract
Cilt yoluyla uygulanan sodyum benzoat (Na-B) 'ın olası sistemik toksik etkilerini incelemek amacıyla kobaylara (n=24) ciltleri lasere edilerek % 10 'luk Na-B çözeltisi sürüldü. 21 günlük deney periyodunu takiben kobayların serumlarında glukoz, üre, sodyum (Na+), potasyum (K+), klorür (Ct), total kalsiyum (Ca) ve inorganik fosfat (P) düzeyleri ölçüldü. Na-B uygulanan grupta kreatinin düzeyini kontrol grubuna (n=24) göre anlamlı (sırasıyla p < 0.01 ve p < 0. 05) olarak daha yüksek bulundu. Glukoz ve üre ile diğer parametrelerin korelasyonları da incelendi. Glukozla-P; arasında kontrol ve Na-B grubunda anlamlı pozitif (sırasıyla p < 0. 05 r= 0. 445 ve p < 0. 01 r = 0. 590) korelasyon olduğu saptandı. Üreyle-kreatinin arasında kontrol grubunda anlamlı pozitif (p < 0.001 r=0.680) bir ilişki bulundu. Oysa Na-B grubunda bu ilişki yine anlamlı (p < 0.05) fakat ters yönde (r = -0.450) idi. Sonuçta, Na-B ın cilt yoluyla emilip serum kreatinin ve K+ düzeylerinde artışa yol açarak sistemik toksik etkiler yaratabileceği kanısına varıldı.
To investigate the possible systemic toxic effects of sodium benzoate (Na-B) which was administered to skin, 10 % Na-B solution was applied to lacerated guinea pig (n=24) skins. Following the experimental period of 21 days; glucose, urea, creatinine, sodium (Na+), potassium (K), chloride (Ct), total calcium (Ca) and inorganic phosphate (P) were measured in these guinea pigs' sera. In the Na-B applied group, creatinine and K levels were significantly (p < 0.01 and 0.05 respectively) higher than the control group. The correlations of these values with serum glucose and urea were investigated, also. Glucose and P were positively correlated to each other in the control and Na-B groups (p < 0.05 r=0.445 and p < 0. 01 r=0.590 respectively). lt was found out that there was a significant positive (p < 0. 001 r=0. 680) relation between urea and creatinine in the control group. However, in the Na-B group, this relation was inversely significant (p < 0. 05 r= 0. 450). Finally, it is concluded that Na-B abs or bed through the skin leads to increases in serum K' and creatinine levels and so might cause systemic toxic effects.
To investigate the possible systemic toxic effects of sodium benzoate (Na-B) which was administered to skin, 10 % Na-B solution was applied to lacerated guinea pig (n=24) skins. Following the experimental period of 21 days; glucose, urea, creatinine, sodium (Na+), potassium (K), chloride (Ct), total calcium (Ca) and inorganic phosphate (P) were measured in these guinea pigs' sera. In the Na-B applied group, creatinine and K levels were significantly (p < 0.01 and 0.05 respectively) higher than the control group. The correlations of these values with serum glucose and urea were investigated, also. Glucose and P were positively correlated to each other in the control and Na-B groups (p < 0.05 r=0.445 and p < 0. 01 r=0.590 respectively). lt was found out that there was a significant positive (p < 0. 001 r=0. 680) relation between urea and creatinine in the control group. However, in the Na-B group, this relation was inversely significant (p < 0. 05 r= 0. 450). Finally, it is concluded that Na-B abs or bed through the skin leads to increases in serum K' and creatinine levels and so might cause systemic toxic effects.
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Keywords
Sodyum benzoat, Deriden emilim, Sodium benzoate, Skin absorption
Citation
Dirican, M. vd. (1995). ''Kobaylarda deriye uygulanan sodyum benzoatın sistemik etkileri''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 22(1-2-3), 73-77.