Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model

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dc.contributor.buuauthorÖzyener, Fadıl
dc.contributor.buuauthorÇetinkaya, Merih
dc.contributor.buuauthorAlkan, Tülin
dc.contributor.buuauthorGören, Bülent
dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.buuauthorKurt, Mustafa Ayberk
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı/Neonatoloji Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-4606-6596tr_TR
dc.contributor.orcid0000-0003-3368-8123tr_TR
dc.contributor.researcheridAAH-1792-2021tr_TR
dc.contributor.researcheridAAH-1718-2021tr_TR
dc.contributor.researcheridAAG-8393-2021tr_TR
dc.contributor.researcheridAAH-1641-2021tr_TR
dc.contributor.researcheridAAG-7125-2021tr_TR
dc.contributor.researcheridAAR-4341-2020tr_TR
dc.contributor.scopusid6506242143tr_TR
dc.contributor.scopusid23994946300tr_TR
dc.contributor.scopusid6601953747tr_TR
dc.contributor.scopusid6602543716tr_TR
dc.contributor.scopusid8450193200tr_TR
dc.contributor.scopusid35603735000tr_TR
dc.contributor.scopusid7003323615tr_TR
dc.date.accessioned2022-03-23T13:48:21Z
dc.date.available2022-03-23T13:48:21Z
dc.date.issued2012
dc.description.abstractPurpose: The objective of this study was to compare the effects of two neuroprotective agents; melatonin, a free radical scavenger and topiramate, AMPA/kainate receptor antagonist, administered alone or in combination in neonatal hypoxic-ischemic model. Methods: After being anesthetized, 7-day-old pups underwent ischemia followed by exposure to hypoxia. The pups were divided into 4 groups in order to receive the vehicle, melatonin, topiramate and combination of topiramate and melatonin. These were administered intraperitoneally for three times; the first before ischemia, the second after hypoxia and the third 24 hours after the second dose. After sacrification, infarct volume and apoptosis were evaluated. Results: Percent infarcted brain volume was significantly reduced in rats which received drugs compared with those which received the vehicle. The number of TUNEL positive cells per unit area in hippocampus and cortex were markedly reduced in drug treated groups compared with control group. No significant differences were found regarding percent infarcted brain volume and number of TUNEL positive cells among drug-treated groups. Conclusions: Melatonin and topiramate, administered either alone or in combination significantly reduced the percent infarcted brain volume and number of TUNEL positive cells suggesting that these agents may confer benefit in treatment of infants with hypoxic-ischemic encephalopathy.en_US
dc.identifier.citationÖzyener, F. vd. (2012). "Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model". Restorative Neurology and Neuroscience, 30(5), 435-444.en_US
dc.identifier.endpage444tr_TR
dc.identifier.issn0922-6028
dc.identifier.issn1878-3627
dc.identifier.issue5tr_TR
dc.identifier.pubmed22751353tr_TR
dc.identifier.scopus2-s2.0-84866878763tr_TR
dc.identifier.startpage435tr_TR
dc.identifier.urihttps://doi.org/10.3233/RNN-2012-120217
dc.identifier.urihttps://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn120217
dc.identifier.urihttp://hdl.handle.net/11452/25311
dc.identifier.volume30tr_TR
dc.identifier.wos000308706800007tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherIOS Pressen_US
dc.relation.bapT-2800/60tr_TR
dc.relation.journalRestorative Neurology and Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectCombination therapyen_US
dc.subjectHypoxia-ischemiaen_US
dc.subjectMelatoninen_US
dc.subjectNeuroprotectionen_US
dc.subjectTopiramateen_US
dc.subjectBrain-damageen_US
dc.subjectProtective roleen_US
dc.subjectCell-deathen_US
dc.subjectNewbornen_US
dc.subjectInjuryen_US
dc.subjectReductionen_US
dc.subjectInfanten_US
dc.subject.emtreeMelatoninen_US
dc.subject.emtreeTopiramateen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBrain cortexen_US
dc.subject.emtreeBrain infarction sizeen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeHippocampusen_US
dc.subject.emtreeHypoxic ischemic encephalopathyen_US
dc.subject.emtreeNeuroprotectionen_US
dc.subject.emtreeNewbornen_US
dc.subject.emtreeNick end labelingen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.meshAnalysis of varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, newbornen_US
dc.subject.meshBrainen_US
dc.subject.meshBrain infarctionen_US
dc.subject.meshCaspase 3en_US
dc.subject.meshCell counten_US
dc.subject.meshCell deathen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshDrug administration scheduleen_US
dc.subject.meshDrug therapy, combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshFructoseen_US
dc.subject.meshHypoxia-ischemia, brainen_US
dc.subject.meshIn situ nick-end labelingen_US
dc.subject.meshMaleen_US
dc.subject.meshMelatoninen_US
dc.subject.meshNeuroprotective agentsen_US
dc.subject.meshRatsen_US
dc.subject.scopus5-Methoxytryptamine; Melatonin; Luzindoleen_US
dc.subject.wosNeurosciencesen_US
dc.titleNeuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat modelen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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