Cytogenetic results of amniocentesis materials: Incidence of abnormal karyotypes in the Turkish collaborative study

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dc.contributor.authorKaraoğuz, Meral Yirmibeş
dc.contributor.authorBal, Fatma
dc.contributor.authorErcelen, N. Özturk
dc.contributor.authorErgün, Mehmet Ali
dc.contributor.authorGökçen, A. Balcı
dc.contributor.authorBiri, Aydan Asyalı
dc.contributor.authorUrman, B.
dc.contributor.authorGültomruk, M.
dc.contributor.authorMenevse, S.
dc.contributor.buuauthorYakut, Tülay
dc.contributor.buuauthorKimya, Yalçın
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid6603919968tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.date.accessioned2021-10-20T08:43:35Z
dc.date.available2021-10-20T08:43:35Z
dc.date.issued2006
dc.description.abstractCytogenetic results of amniocentesis materials: incidence of abnormal karyotypes in the Turkish collaborative study: The experience on prenatal chromosome diagnosis of four Turkish centers participating in a collaborative study on 6041 genetic amniocentesis performed during a 4-8 years period were reviewed. 5887 (97.5%) patients had strong clinical indications for prenatal chromosome studies and 154 (2.5%) were referred because of maternal anxiety and a bad history of previous gestations. The main indication groups were: advanced maternal age (3197 cases), positive serum screening (2011 cases), ultrasound-identified anomaly (492 cases), previous fetus/child with chromosomal aberrations (103 cases), a history of a previous abnormal and / or mentally handicapped child (70 cases) and a parental chromosome rearrangement (14 cases). The average maternal age was 33.9 years and average gestational age was 18 weeks. A total of 179 affected fetuses were detected in this collaborative study (3%) of which 133 were unbalanced (74.3%). Among the 124 (69%) numerical aberrations, 102 (82.3%) were autosomal aneuploidies, 20 (16.1%) were gonosomal aneuploidies and 2 (1.6%) were poliploidies. Among the 55 (31%) structural aberrations, balanced translocation was the most common (63.6%) and I 1 cases of inversion, four cases of unbalanced translocation, two cases of marker chromosome and three cases of other abnormalities were found. The overall culture success rate was 99.7%. Pregnancy termination that is permitted by legal authorities was accepted by 94.7% (126/133) with parents at unbalanced cytogenetic result announcement.en_US
dc.identifier.citationKaraoğuz, M. Y. vd. (2006). ''Cytogenetic results of amniocentesis materials: Incidence of abnormal karyotypes in the Turkish collaborative study''. Genetic Counseling, 17(2), 219-230.en_US
dc.identifier.endpage230tr_TR
dc.identifier.issn1015-8146
dc.identifier.issue2tr_TR
dc.identifier.pubmed16970041tr_TR
dc.identifier.scopus2-s2.0-33748283130tr_TR
dc.identifier.startpage219tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/22420
dc.identifier.volume17tr_TR
dc.identifier.wos000240232100011tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherMedecine Et Hygieneen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalGenetic Counselingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiotechnology & applied microbiologyen_US
dc.subjectGenetics & heredityen_US
dc.subjectMedical ethicsen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectPrenatal diagnosisen_US
dc.subjectIndicationsen_US
dc.subjectAneuploidiesen_US
dc.subjectAmniocentesisen_US
dc.subjectAberrationsen_US
dc.subjectCanadaen_US
dc.subjectDisordersen_US
dc.subjectNondisjunctionen_US
dc.subjectDown-syndromeen_US
dc.subjectChromosome analysisen_US
dc.subjectUnconjugated estriolen_US
dc.subjectGenetic amniocentesisen_US
dc.subjectPrenatal-diagnosisen_US
dc.subjectSerum alpha-fetoproteinen_US
dc.subject.emtreeSex chromosomeen_US
dc.subject.emtreePolyploidyen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeKaryotypeen_US
dc.subject.emtreeIncidenceen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeCytogeneticsen_US
dc.subject.emtreeChromosome rearrangementen_US
dc.subject.emtreeAutosome aberrationen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAneuploidyen_US
dc.subject.emtreeAmniocentesisen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAdolescenten_US
dc.subject.meshTurkeyen_US
dc.subject.meshTrisomyen_US
dc.subject.meshTissue and organ harvestingen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshPrenatal diagnosisen_US
dc.subject.meshPregnancyen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshKaryotypingen_US
dc.subject.meshHumansen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshGene expressionen_US
dc.subject.meshFetal diseasesen_US
dc.subject.meshFemaleen_US
dc.subject.meshCytogeneticsen_US
dc.subject.meshChromosome aberrationsen_US
dc.subject.meshCatchment area (health)en_US
dc.subject.meshAneuploidyen_US
dc.subject.meshAmniocentesisen_US
dc.subject.meshAdulten_US
dc.subject.meshAdolescenten_US
dc.subject.scopusChorion Villus Sampling; Amniocentesis; Maternal Ageen_US
dc.subject.wosBiotechnology & applied microbiologyen_US
dc.subject.wosGenetics & heredityen_US
dc.subject.wosMedical ethicsen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.titleCytogenetic results of amniocentesis materials: Incidence of abnormal karyotypes in the Turkish collaborative studyen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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