Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure

dc.contributor.authorRubio, Camila Peres
dc.contributor.authorTanaka, Ryou
dc.contributor.authorKoch, Jorgen
dc.contributor.authorCeron, Jose Joaquin
dc.contributor.buuauthorSarıl, Ahmet
dc.contributor.buuauthorKocatürk, Meriç
dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2849-1222tr_TR
dc.contributor.researcheridDQX-5263-2022tr_TR
dc.contributor.researcheridGGO-7900-2022tr_TR
dc.contributor.scopusid57202390224tr_TR
dc.contributor.scopusid36437200800tr_TR
dc.contributor.scopusid35944810500tr_TR
dc.date.accessioned2023-01-23T09:33:58Z
dc.date.available2023-01-23T09:33:58Z
dc.date.issued2020-11-10
dc.description.abstractBackgroundHeart failure (HF) is associated with changes in inflammatory and oxidative stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarkers in dogs with different stages of HF and its relation with the severity of the disease and echocardiographic changes. A total of 29 dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included and classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage HF) according to the ACVIM staging system. In these dogs an ecnhocardiographic examination was performed and cytokines, and inflammatory and oxidative stress markers were evaluated in serum.ResultsKC-like was significantly increased in dogs of stage-C (P<0.01) and -D (P<0.05) compared with stage-A and -B. Stage-D dogs showed significantly higher serum CRP and Hp (P<0.05) but lower serum antioxidant capacity (PON1, TEAC, CUPRAC, and thiol) compared to stage-A and -B (P<0.05). After the treatment, serum levels of CRP, Hp and KC-like decreased and serum antioxidant levels increased compared to their pre-treatment values. Left ventricular dimension and LA/Ao ratio correlated positively with CRP, MCP-1, and KC-like but negatively with PON1, GM-CSF, IL-7 and antioxidant biomarkers (P<0.01).ConclusionOur results showed that dogs with advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF. Some of these biomarkers of inflammation and oxidative stress could have the potential to be biomarkers to monitor the severity of the disease and the effect of treatment.en_US
dc.identifier.citationRubio, C. P. vd. (2020). "Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure". BMC Veterinary Research, 16(1).en_US
dc.identifier.issn1746-6148
dc.identifier.issue1tr_TR
dc.identifier.pubmed33167963tr_TR
dc.identifier.scopus2-s2.0-85095703346tr_TR
dc.identifier.urihttps://doi.org/10.1186/s12917-020-02650-7
dc.identifier.urihttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-020-02650-7
dc.identifier.urihttp://hdl.handle.net/11452/30600
dc.identifier.volume16tr_TR
dc.identifier.wos000590713300004tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherBMCtr_TR
dc.relation.bapOUAP(V)-2018/12tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalBMC Veterinary Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVeterinary sciencesen_US
dc.subjectCytokinesen_US
dc.subjectChemokinesen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.subjectHeart failureen_US
dc.subjectDogsen_US
dc.subjectMitral-valve diseaseen_US
dc.subjectTotal antioxidant capacityen_US
dc.subjectProtein concentrationsen_US
dc.subjectSystemic inflammationen_US
dc.subjectParaoxonase 1en_US
dc.subjectLeft atrialen_US
dc.subjectSerumen_US
dc.subjectCytokinesen_US
dc.subjectMarkersen_US
dc.subjectVolumeen_US
dc.subject.emtreeAntioxidanten_US
dc.subject.emtreeAryldialkylphosphatase 1en_US
dc.subject.emtreeBilirubinen_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeC reactive proteinen_US
dc.subject.emtreeCholinesteraseen_US
dc.subject.emtreeDigoxinen_US
dc.subject.emtreeDiltiazemen_US
dc.subject.emtreeEnalaprilen_US
dc.subject.emtreeFerritinen_US
dc.subject.emtreeFurosemideen_US
dc.subject.emtreeGamma interferonen_US
dc.subject.emtreeGamma interferon inducible protein 10en_US
dc.subject.emtreeGranulocyte macrophage colony stimulating factoren_US
dc.subject.emtreeHaptoglobinen_US
dc.subject.emtreeInterleukin 10en_US
dc.subject.emtreeInterleukin 15en_US
dc.subject.emtreeInterleukin 18en_US
dc.subject.emtreeInterleukin 2en_US
dc.subject.emtreeInterleukin 6en_US
dc.subject.emtreeInterleukin 7en_US
dc.subject.emtreeInterleukin 8en_US
dc.subject.emtreeKeratinocyte derived chemokineen_US
dc.subject.emtreeMonocyte chemotactic protein 1en_US
dc.subject.emtreePimobendanen_US
dc.subject.emtreeSpironolactoneen_US
dc.subject.emtreeThiazide diuretic agenten_US
dc.subject.emtreeTorasemideen_US
dc.subject.emtreeTroponin Ien_US
dc.subject.emtreeTumor necrosis factoren_US
dc.subject.emtreeAntioxidanten_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeCytokineen_US
dc.subject.emtreeABTS radical scavenging assayen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAntioxidant assayen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCongestive cardiomyopathyen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeDogen_US
dc.subject.emtreeEchocardiographyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHeart failureen_US
dc.subject.emtreeHeart ventricle remodelingen_US
dc.subject.emtreeImmunoturbidimetryen_US
dc.subject.emtreeInflammationen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreeThorax radiographyen_US
dc.subject.emtreeTrolox equivalent antioxidant capacityen_US
dc.subject.emtreeUrea nitrogen blood levelen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeCardiomyopathyen_US
dc.subject.emtreeDogen_US
dc.subject.emtreeDog diseaseen_US
dc.subject.emtreeHeart failureen_US
dc.subject.emtreeInflammationen_US
dc.subject.emtreeMitral valveen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeValvular heart diseaseen_US
dc.subject.emtreeVeterinary medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshBiomarkersen_US
dc.subject.meshCardiomyopathiesen_US
dc.subject.meshCytokinesen_US
dc.subject.meshDog diseasesen_US
dc.subject.meshDogsen_US
dc.subject.meshEchocardiographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart failureen_US
dc.subject.meshHeart valve diseasesen_US
dc.subject.meshInflammationen_US
dc.subject.meshMaleen_US
dc.subject.meshMitral valveen_US
dc.subject.meshOxidative stressen_US
dc.subject.scopusPimobendan; Mitral Valve Disease; Cavalier King Charles Spanielen_US
dc.subject.wosVeterinary sciencesen_US
dc.titleChanges of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failureen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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