The relation between liver histopathology and GGT levels in viral hepatitis: More important in hepatitis B

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dc.contributor.buuauthorEminler, Ahmet Tarık
dc.contributor.buuauthorIrak, Kader
dc.contributor.buuauthorAyyıldız, Talat
dc.contributor.buuauthorKeskin, Murat
dc.contributor.buuauthorKıyıcı, Murat
dc.contributor.buuauthorGürel, Selim
dc.contributor.buuauthorGülten, Macit
dc.contributor.buuauthorDolar, Enver
dc.contributor.buuauthorNak, Selim Giray
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3208-6211tr_TR
dc.contributor.researcheridAAG-9177-2021tr_TR
dc.contributor.researcheridR-8751-2019tr_TR
dc.contributor.researcheridAAI-4213-2021tr_TR
dc.contributor.scopusid24066287600tr_TR
dc.contributor.scopusid37080733400tr_TR
dc.contributor.scopusid6603155277tr_TR
dc.contributor.scopusid23050640000tr_TR
dc.contributor.scopusid6507627491tr_TR
dc.contributor.scopusid7003706434tr_TR
dc.contributor.scopusid6603629209tr_TR
dc.contributor.scopusid6602075084tr_TR
dc.contributor.scopusid6603336505tr_TR
dc.date.accessioned2022-09-16T06:18:57Z
dc.date.available2022-09-16T06:18:57Z
dc.date.issued2014-08
dc.description.abstractBackground/Aims: To investigate the relationship between gamma-glutamyl transpeptidase (GGT) levels and histopathological status determined by biopsy in patients with chronic hepatitis B and C. Materials and Methods: Patients with chronic hepatitis B and C who were referred to the Uludag University Faculty of Medicine Gastroenterology outpatient clinic between January 2005-January 2011 and underwent liver biopsy were included in the study. Overall, 246 patients with hepatitis B and 151 patients with hepatitis C were enrolled. According to the evaluation based on the Ishak score, patients with a histological activity index (HAI) between 0-12 were defined as low activity, and those with an HAI between 13-18 were defined as high activity. In addition, patients with a fibrosis score of 0-2 were defined as low fibrosis, and those with a score between 3-6 were defined as high fibrosis; comparisons were made accordingly. Results: In patients with hepatitis B, the mean GGT level was 38.86 +/- 42.4 (IU/L) in the low activity group and 60.44 +/- 44.4 (IU/L) in the high activity group (p<0.05). In hepatitis B patients, the mean GGT level was 26.89 +/- 14.83 (IU/L) in the low fibrosis group, whereas it was 65.60 +/- 59.7 (IU/L) in the high fibrosis group (p<0.001). There was no significant difference between HAI and fibrosis group with regard to GGT levels in the hepatitis C patients. Conclusion: In conclusion, it is proposed that in patients with chronic viral hepatitis, GGT levels can be taken into consideration to predict advanced histological liver damage, especially in patients with hepatitis B.en_US
dc.identifier.citationEminler, A. T. vd. (2014). "The relation between liver histopathology and GGT levels in viral hepatitis: More important in hepatitis B". Turkish Journal of Gastroenterology, 25(4), 411-415.tr_TR
dc.identifier.endpage415tr_TR
dc.identifier.issn1300-4948
dc.identifier.issn2148-5607
dc.identifier.issue4tr_TR
dc.identifier.pubmed25254524tr_TR
dc.identifier.scopus2-s2.0-84908149154tr_TR
dc.identifier.startpage411tr_TR
dc.identifier.urihttps://doi.org/10.5152/tjg.2014.3693
dc.identifier.urihttps://www.turkjgastroenterol.org/en/the-relation-between-liver-histopathology-and-ggt-levels-in-viral-hepatitis-more-important-in-hepatitis-b-1622664
dc.identifier.urihttp://hdl.handle.net/11452/28769
dc.identifier.volume25tr_TR
dc.identifier.wos000345025900012tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.journalTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGGTen_US
dc.subjectViral hepatitisen_US
dc.subjectLiver pathologyen_US
dc.subjectC virus-infectionen_US
dc.subjectBiochemical markersen_US
dc.subjectFibrosisen_US
dc.subjectGastroenterology & hepatologyen_US
dc.subject.emtreeGamma glutamyltransferaseen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeAlkaline phosphataseen_US
dc.subject.emtreeAspartate aminotransferaseen_US
dc.subject.emtreeGamma glutamyltransferaseen_US
dc.subject.emtreeVirus DNAen_US
dc.subject.emtreeVirus RNAen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGamma glutamyl transferase blood levelen_US
dc.subject.emtreeHepatitis Ben_US
dc.subject.emtreeHepatitis Cen_US
dc.subject.emtreeHistological activity indexen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeIshak scoreen_US
dc.subject.emtreeLiver biopsyen_US
dc.subject.emtreeLiver fibrosisen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNamed inventoriesen_US
dc.subject.emtreeQuestionnaires and rating scalesen_US
dc.subject.emtreePatient referralen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeBiopsyen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeChronic hepatitis Cen_US
dc.subject.emtreeEnzymologyen_US
dc.subject.emtreeHepatitis Ben_US
dc.subject.emtreeInternational normalized ratioen_US
dc.subject.emtreeLiveren_US
dc.subject.emtreeLiver cirrhosisen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeSeverity of illness indexen_US
dc.subject.emtreeThrombocyte counten_US
dc.subject.emtreeYoung adulten_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAlanine transaminaseen_US
dc.subject.meshAlkaline phosphataseen_US
dc.subject.meshAspartate aminotransferasesen_US
dc.subject.meshBiopsyen_US
dc.subject.meshDNA, viralen_US
dc.subject.meshGamma-glutamyltransferaseen_US
dc.subject.meshHepatitis B, chronicen_US
dc.subject.meshHepatitis C, chronicen_US
dc.subject.meshHumansen_US
dc.subject.meshInternational normalized ratioen_US
dc.subject.meshLiveren_US
dc.subject.meshLiver cirrhosisen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPlatelet counten_US
dc.subject.meshRNA, viralen_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusGamma-Glutamyltransferase; Alanine Aminotransferase; Biomarkersen_US
dc.subject.wosGastroenterology & hepatologyen_US
dc.titleThe relation between liver histopathology and GGT levels in viral hepatitis: More important in hepatitis Ben_US
dc.typeArticle

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