Effects of hormone replacement therapy regimens on mammographic breast density: The role of progestins

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dc.contributor.buuauthorTopal, Naile Bolca
dc.contributor.buuauthorAyhan, Serdal
dc.contributor.buuauthorTopal, Uğur
dc.contributor.buuauthorBilgin, Tufan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyoloji Bölümü.tr_TR
dc.contributor.researcheridAAI-2327-2021tr_TR
dc.date.accessioned2021-09-28T13:31:27Z
dc.date.available2021-09-28T13:31:27Z
dc.date.issued2006
dc.description.abstractTo evaluate the effects of different regimens of hormone replacement therapy (HRT) on mammographic breast density. Mammograms of 113 healthy postmenopausal women who were on different HRT regimens were evaluated retrospectively. All women had a baseline mammography and at least one mammogram after at least 12 months of HRT. Four parenchymal patterns were considered mammographically. Quantification of density changes that occurred on follow-up mammograms was done qualitatively and with reference to densities on baseline mammograms. Sixty women were treated with a continuous estrogen-progestin combination; 16 with a cyclic estrogen-progestin combination and 37 were with estrogen only. Twenty-six women had increased mammographic density after HRT. Mammographic density increase was detected in 23 women (38.3%) of the continuous estrogen-progestin combination group, two women (12.5%) of the cyclic estrogen-progestin combination group and one woman (2.7%) of the estrogen-only group. Mammographic density increase was more common among women in the continuous estrogen-progestin combination group than the other groups and this difference was found to be statistically significant (P < 0.001). Breast density increase was observed in 18 of 30 women (60%) with higher doses of progestin compared to 5 of 30 women (16.7%) with lower dose (P < 0.05). Postmenopausal HRT may increase mammographic breast density. Breast density appears to be mostly affected by higher doses and continuous administration of progestin.en_US
dc.identifier.citationTopal, N, B, vd. (2006). ''Effects of hormone replacement therapy regimens on mammographic breast density: The role of progestins''. Journal of Obstetrıcs and Gynaecology Research, 32(3), 305-308.en_US
dc.identifier.endpage308tr_TR
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue3tr_TR
dc.identifier.pubmed16764621tr_TR
dc.identifier.scopus2-s2.0-33744484557tr_TR
dc.identifier.startpage305tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2006.00402.x
dc.identifier.urihttps://obgyn.onlinelibrary.wiley.com/doi/10.1111/j.1447-0756.2006.00402.x
dc.identifier.urihttp://hdl.handle.net/11452/22117
dc.identifier.volume32tr_TR
dc.identifier.wos000237694700007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstetrics & gynecologyen_US
dc.subjectMenopauseen_US
dc.subjectMammographyen_US
dc.subjectHormone replacement therapyen_US
dc.subjectBreasten_US
dc.subjectRisksen_US
dc.subjectWomenen_US
dc.subjectCanceren_US
dc.subject.scopusBreast Density; Mammography; Cancer Risken_US
dc.subject.wosObstetrics & gynecologyen_US
dc.titleEffects of hormone replacement therapy regimens on mammographic breast density: The role of progestinsen_US
dc.typeArticle

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