The relationship between serum lectin-like oxidized LDL receptor-1 levels and systolic heart failure
No Thumbnail Available
Date
2015-05-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
Objectives Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. In this study, we aimed to evaluate the utility of serum LOX-1 levels in the diagnosis and assessment of left ventricular systolic HF and LOX-1's relationship with serum pro-brain natriuretic peptide (NT-proBNP). Design and settings This was a cross-sectional study of all eligible patients admitted to the department of cardiology of the University Hospital between July 2011 and April 2012. Methods Fifty-five patients with a diagnosis of systolic heart failure and 25 patients without systolic HF were enrolled in this study. Serum C-reactive protein, NT-proBNP, and LOX-1 were studied. Results Serum LOX-1 and NT-proBNP levels were significantly higher in the heart failure group and showed a positive correlation with NT-proBNP and negative correlations with left ventricular ejection fraction (EF). In addition, LOX-1 levels in patients with ischaemic cardiomyopathy were significantly higher, while they were similar in patients with dilated cardiomyopathy compared to control subjects. Conclusion Our study demonstrates the utility of the serum LOX-1 levels in the diagnosis of left ventricular systolic heart failure. LOX-1 may have a place in the diagnosis of heart failure, in particular in patients with ischaemic cardiomyopathy.
Description
Keywords
Cardiovascular system & cardiology, Left ventricular systolic heart failure, NT pro-brain natriuretic peptide, Lectin-like oxidized LDL receptor-1, Ejection fraction, Density-lipoprotein receptor-1, Guidelines, Diagnosis
Citation
Beşli, F. vd. (2016). "The relationship between serum lectin-like oxidized LDL receptor-1 levels and systolic heart failure". Acta Cardiologica, 71(2), 185-190.