The effects of a fluoroquinolone on the growth and development of infants
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Date
1997
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Publisher
Cambridge Med Publ
Abstract
Growth and development were monitored for up to 42 months in nine neonates to whom ciprofloxacin, a fluoroquinolone, was given in the neonatal period at a dosage of 20 mg/kg/day. Ciprofloxacin was used only as a 'life-saving' therapy in cases of sepsis produced by bacterial agents resistant to other antibiotics. Two other groups of nine neonates, matched by birth weight and gestational age, were studied as controls: one group with sepsis, which was effectively treated with cefotaxime and a group of healthy neonates. No statistically significant differences in growth and development between the groups were found during follow-up for 42 months. No osteoarticular problems or joint deformities were observed in the ciprofloxacin group. Ciprofloxacin appears to provide a therapeutic option as a 'life-saving' therapy for newborns with sepsis produced by multiply resistant organisms.
Description
Keywords
Research & experimental medicine, Pharmacology & pharmacy, Ciprofloxacin, Fluoroquinolones, Guinolones, Antibacterial drugs, Sepsis, Neonates, Growth, Development
Citation
Gürpınar, A. N. vd. (1997). "The effects of a fluoroquinolone on the growth and development of infants". Journal of International Medical Research, 25(5), 302-306.