Imaging of active multiple sclerosis plaques: Efficiency of contrast-enhanced magnetization transfer subtraction technique

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dc.contributor.buuauthorAlgın, Oktay
dc.contributor.buuauthorHakyemez, Bahattin
dc.contributor.buuauthorTaşkapılıoğlu, Özlem
dc.contributor.buuauthorParlak, Müfit
dc.contributor.buuauthorTuran, Faruk
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3425-0740tr_TR
dc.contributor.orcid0000-0002-3877-8366tr_TR
dc.contributor.researcheridAAI-2318-2021tr_TR
dc.contributor.scopusid23995109100tr_TR
dc.contributor.scopusid6602527239tr_TR
dc.contributor.scopusid23037226400tr_TR
dc.contributor.scopusid7003589220tr_TR
dc.contributor.scopusid17636734100tr_TR
dc.date.accessioned2022-03-25T05:32:15Z
dc.date.available2022-03-25T05:32:15Z
dc.date.issued2010-06
dc.description.abstractPURPOSE T1-weighted (T1W) magnetic resonance images with magnetization transfer (MT) are widely used in the evaluation of multiple sclerosis (MS) plaques. We aimed to evaluate the contribution of the subtraction technique with MT in the detection of acute MS plaques. MATERIALS AND METHODS Sixty-four patients during an MS attack were enrolled in the study. Axial T1W spin echo (SE) with MT, axial-sagittal T2W fast SE, axial FLAIR and postcontrast axial T1W SE magnetic resonance imaging sequence with MT were acquired from all patients. The subtraction (postcontrast-precontrast) images were obtained on the workstation. FLAIR and T2W images were used as reference for plaque imaging. Contrast material enhanced plaques were considered as acute plaques. Qualitatively, both subtracted and contrast-enhanced with MT images were evaluated visually. Quantitatively, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. RESULTS A total of 464 plaques were detected on T2W and FLAIR images. Thirty-five acute plaques were detected on both postcontrast MT and subtracted images. Additionally, 66 acute plaques were only detected on subtracted images visually. CNR and SNR values of acute MS plaques were significantly higher on subtracted MT images than on postcontrast MT images (P < 0.001). CONCLUSION The subtraction technique seems to facilitate the detection of acute MS plaques by intensifying the visibility of poorly enhanced plaques without use of high dose contrast medium. We suggest the use of subtraction technique in routine imaging work-up of MS patients with acute attacks.en_US
dc.identifier.citationAlgın, O. vd. (2010). "Imaging of active multiple sclerosis plaques: Efficiency of contrast-enhanced magnetization transfer subtraction technique". Diagnostic and Interventional Radiology, 16(2), 106-111.tr_TR
dc.identifier.endpage111tr_TR
dc.identifier.issn1305-3825
dc.identifier.issn1305-3612
dc.identifier.issue2tr_TR
dc.identifier.pubmed20309819tr_TR
dc.identifier.scopus2-s2.0-77954880089tr_TR
dc.identifier.startpage106tr_TR
dc.identifier.urihttps://doi.org/10.4261/1305-3825.DIR.2879-09.1
dc.identifier.urihttp://hdl.handle.net/11452/25324
dc.identifier.volume16tr_TR
dc.identifier.wos000278427200003tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTürk Radyoloji Derneğitr_TR
dc.relation.journalDiagnostic and Interventional Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectMagnetization transfer contrast imagingen_US
dc.subjectMultiple sclerosisen_US
dc.subjectGadolinium-DTPAen_US
dc.subjectBrain-MRen_US
dc.subjectSpectroscopyen_US
dc.subjectLesionsen_US
dc.subjectMatteren_US
dc.subjectRadiology, nuclear medicine & medical imagingen_US
dc.subject.emtreeGadolinium pentetateen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeContrast enhancementen_US
dc.subject.emtreeContrast noise ratioen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeElectrical parametersen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeImage qualityen_US
dc.subject.emtreeImage subtractionen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMultiple sclerosisen_US
dc.subject.emtreeNuclear magnetic resonance imagingen_US
dc.subject.emtreeQuantitative analysisen_US
dc.subject.emtreeRelapseen_US
dc.subject.emtreeSignal noise ratioen_US
dc.subject.meshAdulten_US
dc.subject.meshAge of onseten_US
dc.subject.meshBrainen_US
dc.subject.meshContrast mediaen_US
dc.subject.meshDiagnostic imagingen_US
dc.subject.meshDisabled personsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGadoliniumen_US
dc.subject.meshGadolinium DTPAen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic resonance imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMultiple sclerosis, relapsing-remittingen_US
dc.subject.meshSclerosisen_US
dc.subject.meshSubtraction techniqueen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusRelapsing-Remitting Multiple Sclerosis; Grey Matter; Cervical Corden_US
dc.subject.wosRadiology, nuclear medicine & medical imagingen_US
dc.titleImaging of active multiple sclerosis plaques: Efficiency of contrast-enhanced magnetization transfer subtraction techniqueen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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