Prevention of epidural fibrosis in rats by local or systemic administration of citicoline

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dc.contributor.authorUlus, İsmail Hakkı
dc.contributor.buuauthorSavran, Mehmet
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorTolunay, Şahsene
dc.contributor.buuauthorTaşkapılıoğlu, Mevlüt Özgür
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-5472-9065tr_TR
dc.contributor.orcid0000-0003-2918-5064tr_TR
dc.contributor.researcheridAAW-5254-2020tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.researcheridABB-8161-2020tr_TR
dc.contributor.scopusid6506735836tr_TR
dc.contributor.scopusid6603677218tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid6602604390tr_TR
dc.contributor.scopusid25936798300tr_TR
dc.date.accessioned2022-04-22T05:41:17Z
dc.date.available2022-04-22T05:41:17Z
dc.date.issued2012-09
dc.description.abstractAIM: The objective of this study was to investigate the effect of citicoline administration on epidural fibrosis which is a frequent complication of lumbar disc surgery with no effective treatment or preventive surgical technique. MATERIAL and METHODS: Sixty Sprague-Dawley female rats undergoing L4-5 right hemilaminotomy and annular fenestration were arranged in three groups: rats in Group 1 (control group) and Group 2 (topical citicoline group) were applied 0,9% saline and 100 mu M citicoline on surgical area, respectively, while rats in Group 3 (systemic citicoline group) received 600 mu mol/kg citicoline intraperitoneally. Rats were sacrificed four weeks later and their vertebral colons were removed en bloc. Groups were evaluated according to histological criteria and results were compared using statistical tools. RESULTS: Compared with control group, significantly less epidural fibrosis, dural adhesion, fibroblast cell density, foreign body reaction, and medulla spinalis retraction were observed in groups treated with topical and systemic citicoline (groups 2 and 3) (p < 0,001). No significant difference was found with regard to measured parameters between two treatment groups (p > 0,05). CONCLUSION: Our study demonstrates for the first time in the literature that citicoline may be effective for preventing postoperative epidural fibrosis. However, its mechanism of action and clinical effectiveness must be further investigated.en_US
dc.identifier.citationSavran, M. vd. (2012). "Prevention of epidural fibrosis in rats by local or systemic administration of citicoline". Turkish Neurosurgery, 22(5), 634-640.tr_TR
dc.identifier.endpage640tr_TR
dc.identifier.issn1019-5149
dc.identifier.issue5tr_TR
dc.identifier.pubmed23015343tr_TR
dc.identifier.scopus2-s2.0-84870159432tr_TR
dc.identifier.startpage634tr_TR
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.6008-12.0
dc.identifier.urihttp://www.turkishneurosurgery.org.tr/abstract.php?id=1056
dc.identifier.urihttp://hdl.handle.net/11452/25978
dc.identifier.volume22tr_TR
dc.identifier.wos000310118600017tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectSurgeryen_US
dc.subjectEpidural fibrosisen_US
dc.subjectAnnular fenestrationen_US
dc.subjectLaminatomyen_US
dc.subjectCiticolineen_US
dc.subjectRaten_US
dc.subjectBack surgery syndromeen_US
dc.subjectAutonomic nervous-systemen_US
dc.subjectCdp-cholineen_US
dc.subjectPeridural fibrosisen_US
dc.subjectLumbar diskectomyen_US
dc.subjectFunctional recoveryen_US
dc.subjectCerebral-ischemiaen_US
dc.subjectLaminectomy modelen_US
dc.subjectScar formationen_US
dc.subjectAdcon-len_US
dc.subject.scopusLaminectomy; Failed Back Surgery Syndrome; Dura Materen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosSurgeryen_US
dc.titlePrevention of epidural fibrosis in rats by local or systemic administration of citicolineen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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