Atopinin in vitro tanısında phadiatop
Loading...
Date
1991
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Allerjik yakınmalan olan olgularda tanı amacıyla çeşitli laboratuvar testleri yapılmaktadır. Bunlardan total lg E tayini parazitlerin yaygın olarak bulunduğu bölgelerde yanlış sonuçlar verebilmektedir. Deri testlerinin değeri ortaya konmuştur, ancak, küçük çocuklarda, yaygın atopik dennalitli ve dennograjizmi olan olgularda yapılması güçlükler göstermektedir. Son yıllarda atopinin tanısında yeni bir in vitro test olan Phadiatop'un kullanılabileceği ileri sürülmektedir. Phadiatop değişik alerjenleri içeren kağıt diskler yardımıyla serumdaki spesifik lg E antikorlarının bağlanması esasına dayanmaktadır. Bu çalışmada üst ve alt solunum yolları ile ilgili alerjik yakınmalan olan 106 olguda total lg E, deri testleri ve Phadiatop testi yapıldı ve sonuçlar karşılaştırıldı. 106 olgudan 81'i pediatrik, 25'i ise erişkin yaş grubundaydı. Olgulardan 71'inde total lg E yüksek olarak bulundu (% 67). Deri testleri 69 olguda pozitif sonuç verdi (% 65 ). Phadiatop testi ise 65 olguda pozitif olarak bulundu (% 61). Deri testleri ile Phadiatop'un uyumu % 85, deri testleri esas alınarak Phadiatop'un spesifikliği % 86, sensitivitesi % 92 ve etkinliği % 85 olarak bulundu. Bu sonuçlarla Phadiatop'un atopi tanısında in vitro test olarak kullanılabileceği düşünüldü.
Various laboratory tests are used in the diagnosis of allergic diseases. Among these, total lg E can give false positive results in the regions with endemic parasitosis. Skin tests are valuable, but they may show difficulties in small children and in the cases with wide spread atopic dermatitis and dermographism. Recently the use of Phadiatop which is a new in vitro test in the diagnosis of atopy is suggested. Phadiatop is a test in which depends on with the paper discs containing various allergens are used to bind specific lg E anticor in serum. We studied the diagnostic significance of various test such as total lg E level, skin tests and Phadiatop in 106 cases with allergic upper and lower airway findings. 81 of these cases were in pediatric age group and 25 were adult. In 71 cases total lg E levels were found to be higher than normal (67 % ). The skin tests gave positive results in 69 cases (65 %). Phadiatop was found to be positive in 65 cases (61 %). Skin tests and Phadiatop were both found to be positive in 85 % of cases. Phadiatop's specificity and sensitivity were 86 % and 92 % respectively in the diagnosis of atopy. With these results it is suggested that Phadiatop can be used as an in vitro test in the diagnosis of atopy.
Various laboratory tests are used in the diagnosis of allergic diseases. Among these, total lg E can give false positive results in the regions with endemic parasitosis. Skin tests are valuable, but they may show difficulties in small children and in the cases with wide spread atopic dermatitis and dermographism. Recently the use of Phadiatop which is a new in vitro test in the diagnosis of atopy is suggested. Phadiatop is a test in which depends on with the paper discs containing various allergens are used to bind specific lg E anticor in serum. We studied the diagnostic significance of various test such as total lg E level, skin tests and Phadiatop in 106 cases with allergic upper and lower airway findings. 81 of these cases were in pediatric age group and 25 were adult. In 71 cases total lg E levels were found to be higher than normal (67 % ). The skin tests gave positive results in 69 cases (65 %). Phadiatop was found to be positive in 65 cases (61 %). Skin tests and Phadiatop were both found to be positive in 85 % of cases. Phadiatop's specificity and sensitivity were 86 % and 92 % respectively in the diagnosis of atopy. With these results it is suggested that Phadiatop can be used as an in vitro test in the diagnosis of atopy.
Description
Keywords
Atopinin in vitro tanısı, Phadiatop, Dennografizm, In vitro diagnosis of atopy
Citation
Sapan, N. ve Tunalı, Ş. (1991). ''Atopinin in vitro tanısında phadiatop''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 18(1), 51-54.