Effects of vitamin e on phostoxin-ınduced changes in the liver and biochemical parameters of adult wistar rats

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dc.contributor.authorIbegbu, Augustine Oseloka
dc.contributor.authorAlatise, Ahmad Tajudeen
dc.contributor.authorOlaniyi, Babatunde Abdullateef
dc.contributor.authorSamnan, Dassah Julcit
dc.contributor.authorEmmanuel, Umana Uduak
dc.contributor.authorOliver, Hamman Wilson
dc.contributor.authorAbraham, Musa Sunday
dc.contributor.authorSteven, Akpulu Peter
dc.date.accessioned2021-03-10T13:12:09Z
dc.date.available2021-03-10T13:12:09Z
dc.date.issued2013-11-25
dc.description.abstractThe effects of antioxidant Vitamin E on phostoxin-induced changes in the liver and haemato-biochemical parameters in Wistar rats were studied. Thirty adult Wistar rats of both sexes were grouped into six groups of five rats each. Group 1 was the Control and was given normal saline, Group 2 was exposed to phostoxin for 3 hours with vitamin E and Group 3 was exposed to phostoxin for 1½ hours with vitamin E. Groups 4 and 5 were exposed to phostoxin for 3 hours and 1½ hours respectively and Group 6 was treated with vitamin E only. The rats were exposed to phostoxin through inhalational method for one week. At the end of the exposure period, the rats were sacrificed, the blood and tissues collected for analysis and procession for studies. The results showed increase in the body weight of the rats which could be as a result of the effect of phostoxin leading to increase in appetite of the rats. The results of biochemical parameters showed there was significant increase in AST and ALP (P<0.05), but the change in ALT in the serum of treated animals was not significant. The results from the histological observations of the Liver in the experimental rats showed changes in all the Groups that were treated with phostoxin of which the damage was dependent on the exposure time to phostoxin and Vitamin E may play a role as an antioxidant resulting in ameliorative effects in phostoxin-induced toxicity.en_US
dc.identifier.citationIbegbu, A. O. (2013). "Effects of vitamin e on phostoxin-induced changes in the liver and biochemical parameters of adult wistar rats". Journal of Biological and Environmental Sciences, 7(21),121-129.tr_TR
dc.identifier.endpage129tr_TR
dc.identifier.issn1307-9530
dc.identifier.issn1308-2019
dc.identifier.issue21tr_TR
dc.identifier.startpage121tr_TR
dc.identifier.uridergipark.org.tr/tr/download/article-file/497436
dc.identifier.urihttp://hdl.handle.net/11452/17439
dc.identifier.volume7tr_TR
dc.language.isoenen_US
dc.publisherUludağ Üniversitesitr_TR
dc.relation.journalJournal of Biological and Environmental Sciencestr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitamin Etr_TR
dc.subjectPhostoxinen_US
dc.subjectPiochemical parametersen_US
dc.subjectOxidative enzymesen_US
dc.subjectLiveren_US
dc.subjectWistar ratsen_US
dc.titleEffects of vitamin e on phostoxin-ınduced changes in the liver and biochemical parameters of adult wistar ratsen_US
dc.typeArticleen_US

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2013 Cilt 7 Sayı 21