Effects of vitamin e on phostoxin-ınduced changes in the liver and biochemical parameters of adult wistar rats
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Date
2013-11-25
Authors
Ibegbu, Augustine Oseloka
Alatise, Ahmad Tajudeen
Olaniyi, Babatunde Abdullateef
Samnan, Dassah Julcit
Emmanuel, Umana Uduak
Oliver, Hamman Wilson
Abraham, Musa Sunday
Steven, Akpulu Peter
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
The effects of antioxidant Vitamin E on phostoxin-induced changes in the liver and haemato-biochemical parameters in Wistar rats were studied. Thirty adult Wistar rats of both sexes were grouped into six groups of five rats each. Group 1 was the Control and was given normal saline, Group 2 was exposed to phostoxin for 3 hours with vitamin E and Group 3 was exposed to phostoxin for 1½ hours with vitamin E. Groups 4 and 5 were exposed to phostoxin for 3 hours and 1½ hours respectively and Group 6 was treated with vitamin E only. The rats were exposed to phostoxin through inhalational method for one week. At the end of the exposure period, the rats were sacrificed, the blood and tissues collected for analysis and procession for studies. The results showed increase in the body weight of the rats which could be as a result of the effect of phostoxin leading to increase in appetite of the rats. The results of biochemical parameters showed there was significant increase in AST and ALP (P<0.05), but the change in ALT in the serum of treated animals was not significant. The results from the histological observations of the Liver in the experimental rats showed changes in all the Groups that were treated with phostoxin of which the damage was dependent on the exposure time to phostoxin and Vitamin E may play a role as an antioxidant resulting in ameliorative effects in phostoxin-induced toxicity.
Description
Keywords
Vitamin E, Phostoxin, Piochemical parameters, Oxidative enzymes, Liver, Wistar rats
Citation
Ibegbu, A. O. (2013). "Effects of vitamin e on phostoxin-induced changes in the liver and biochemical parameters of adult wistar rats". Journal of Biological and Environmental Sciences, 7(21),121-129.