Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea

Simple item page
dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorOral, Arzu Yılmaztepe
dc.contributor.buuauthorDemirdöǧen, Ezgi Şen
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.buuauthorEge, Ercüment
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0002-7400-9089tr_TR
dc.contributor.orcid0000-0002-7400-9089tr_TR
dc.contributor.researcheridAAI-3169-2021tr_TR
dc.contributor.researcheridA-5841-2017tr_TR
dc.contributor.researcheridAAG-8744-2021tr_TR
dc.contributor.researcheridAAH-9812-2021tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.scopusid8329319900tr_TR
dc.contributor.scopusid6601970351tr_TR
dc.contributor.scopusid23091316500tr_TR
dc.contributor.scopusid14062849300tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.contributor.scopusid6701341320tr_TR
dc.date.accessioned2022-04-22T09:21:45Z
dc.date.available2022-04-22T09:21:45Z
dc.date.issued2008-08
dc.description.abstractObjective: Obesity and obstructive sleep apnea (OSA) and systemic inflammation may interact through biochemical pathways. Neopterin (NP) is a monocyte/macrophage activation marker produced by macrophages in response to interferon-gamma secreted by activated T lymphocytes. This study examines the association between NP, obesity and OSA. Patients and methods: The study included 22 newly diagnosed OSA (+) patients and 18 OSA patients. Subjects with history of coronary artery disease, transplant patients, history of alcohol and drug abuse, history of HIV and any other significant medical. illnesses such as active infections, autoimmune disease, malignancy, liver disease, pulmonary disease (COPD, asthma, ...), neuromuscular disease, patients on immunomodulating therapy or HMG-CoA reductase inhibitors were excluded. Results: There were no significant differences in age, body mass index (BMI), and smoking habits of the OSA (+) patients and OSA (-) patients. Serum NP levels did not show any significant difference between the OSA (+) patients and OSA (-) patients, however, NP levels were positively correlated with BMI (r = 0.320, p = 0.044). There was no significant correlation between NP and any of the polysomnographic parameters. The result of stepwise regression analyses (r 2 = 0.320, p < 0.001) showed that high serum NP levels (p = 0.004) and apnea-hypopnea index (AHI) were a risk factor for elevated Epworth sleepiness score, independent of BMI. Conclusion: We suggest that serum NP levels correlate with BMI. There was a significant relationship between serum NP levels and excessive daytime sleepiness in OSA patients.en_US
dc.identifier.citationUrsavaş, A. vd. (2008). ''Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea". Respiratory Medicine, 102(8), 1193-1197.en_US
dc.identifier.endpage1197tr_TR
dc.identifier.issn0954-6111
dc.identifier.issue8tr_TR
dc.identifier.pubmed18579365tr_TR
dc.identifier.scopus2-s2.0-47249112913tr_TR
dc.identifier.startpage1193tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2008.02.019
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0954611108000954
dc.identifier.urihttp://hdl.handle.net/11452/26011
dc.identifier.volume102tr_TR
dc.identifier.wos000258488900016tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherW B Saundersen_US
dc.relation.journalRespiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subjectRespiratory systemen_US
dc.subjectDaytime sleepinessen_US
dc.subjectNeopterinen_US
dc.subjectObesityen_US
dc.subjectSleep apneaen_US
dc.subjectAcute coronary syndromesen_US
dc.subjectInsulin-resistanceen_US
dc.subjectArtery-diseaseen_US
dc.subjectRisk-factoren_US
dc.subjectKappa-ben_US
dc.subjectThicknessen_US
dc.subjectMarkeren_US
dc.subjectSystemen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArousalen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeGamma interferonen_US
dc.subject.emtreeNeopterinen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDaytime somnolenceen_US
dc.subject.emtreeDaytime somnolenceen_US
dc.subject.emtreeDaytime somnolenceen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeObesityen_US
dc.subject.emtreePolysomnographyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeSleep apnea syndromeen_US
dc.subject.emtreeSleep timeen_US
dc.subject.emtreeSmoking habiten_US
dc.subject.emtreeT lymphocyteen_US
dc.subject.meshAdulten_US
dc.subject.meshBiological markersen_US
dc.subject.meshBody mass indexen_US
dc.subject.meshCross-sectional studiesen_US
dc.subject.meshDisorders of excessive somnolenceen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeopterinen_US
dc.subject.meshObesityen_US
dc.subject.meshPolysomnographyen_US
dc.subject.meshSleep apnea, obstructiveen_US
dc.subject.scopusNeopterin; Kynurenine; Pteridine Derivativeen_US
dc.subject.wosCardiac & cardiovascular systemsen_US
dc.subject.wosRespiratory systemen_US
dc.titleAssociation between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apneaen_US
dc.typeArticle
dc.wos.quartileQ2en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
PubMed
Scopus