Investigation of antioxidant ability of grape seeds extract to prevent oxidatively induced DNA damage by gas chromatography-tandem mass spectrometry
dc.contributor.buuauthor | Aybastıer, Önder | |
dc.contributor.buuauthor | Dawbaa, Sam | |
dc.contributor.buuauthor | Demir, Cevdet | |
dc.contributor.department | Uludağ Üniversitesi/Fen - Edebiyat Fakültesi/Kimya Bölümü. | tr_TR |
dc.contributor.orcid | 0000-0002-0380-1992 | tr_TR |
dc.contributor.orcid | 0000-0001-7001-0739 | tr_TR |
dc.contributor.orcid | 0000-0003-1508-0181 | tr_TR |
dc.contributor.researcherid | X-4621-2018 | |
dc.contributor.researcherid | DUQ-8689-2022 | |
dc.contributor.researcherid | DTQ-5753-2022 | |
dc.contributor.scopusid | 35344478800 | tr_TR |
dc.contributor.scopusid | 55697616600 | tr_TR |
dc.contributor.scopusid | 7003565902 | tr_TR |
dc.date.accessioned | 2024-03-04T12:21:45Z | |
dc.date.available | 2024-03-04T12:21:45Z | |
dc.date.issued | 2018-01-01 | |
dc.description.abstract | Phenolic compounds have been studied elaborately for their efficacy to improve health and to protect against a wide variety of diseases. Herein this study, different analysis methods were implemented to evaluate the antioxidant properties of catechin and cyanidin using their standard substances and as they found in the grape seeds extracts. Total phenol contents were 107.39 +/- 8.94 mg GAE/g dw of grape seeds for grape seed extract (GSE) and 218.32 +/- 10.66 mg GAE/g dw of grape seeds for acid-hydrolyzed grape seed extract (AcGSE). The extracts were analyzed by HPLC-DAD system and the results showed the presence of catechin, gallic acid, chlorogenic acid and ellagic acid in the processed methanolic extract and cyanidin, gallic acid and ellagic acid in the processed acidified methanolic extract. The protective abilities of catechin and cyanidin were tested against the oxidation of DNA. The results showed that cyanidin has better protection of DNA against oxidation than catechin. GSE and AcGSE were revealed to inhibit the oxidatively induced DNA damage. GSE decreased about 57% of damage caused by the Fenton control sample. This study could show new aspects of the antioxidant profiles of cyanidin and catechin. | en_US |
dc.identifier.citation | Aybastıer, Ö. vd. (2018). ''Investigation of antioxidant ability of grape seeds extract to prevent oxidatively induced DNA damage by gas chromatography-tandem mass spectrometry''. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 1072, 328-335. | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.jchromb.2017.11.044 | |
dc.identifier.endpage | 335 | tr_TR |
dc.identifier.issn | 1570-0232 | |
dc.identifier.issn | 1476-5381 | |
dc.identifier.pubmed | 29223045 | tr_TR |
dc.identifier.scopus | 2-s2.0-85037333475 | tr_TR |
dc.identifier.startpage | 328 | tr_TR |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1570023217314770 | |
dc.identifier.uri | https://hdl.handle.net/11452/40181 | |
dc.identifier.volume | 1072 | tr_TR |
dc.identifier.wos | 000433567900005 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.bap | 2013/13 | tr_TR |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Biochemistry & molecular biology | en_US |
dc.subject | Chemistry | en_US |
dc.subject | DNA oxidation | en_US |
dc.subject | Grape seed | en_US |
dc.subject | Catechin | en_US |
dc.subject | Cyanidin | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | GC-MS/MS | en_US |
dc.subject | DNA | en_US |
dc.subject | Drug products | en_US |
dc.subject | Ellagic acid | en_US |
dc.subject | Flavonoids | en_US |
dc.subject | Gas chromatography | en_US |
dc.subject | Mass spectrometry | en_US |
dc.subject | Organic compounds | en_US |
dc.subject | Oxidation | en_US |
dc.subject | Antioxidant properties | en_US |
dc.subject | DNA oxidation | en_US |
dc.subject | Gas chromatography-tandem mass spectrometry | en_US |
dc.subject | Grape seeds | en_US |
dc.subject | Methanolic extracts | en_US |
dc.subject | Total phenol contents | en_US |
dc.subject | Phenols | en_US |
dc.subject.emtree | Catechin | en_US |
dc.subject.emtree | Chlorogenic acid | en_US |
dc.subject.emtree | Cyanidin | en_US |
dc.subject.emtree | Ellagic acid | en_US |
dc.subject.emtree | Ferrous gluconate | en_US |
dc.subject.emtree | Gallic acid | en_US |
dc.subject.emtree | Grape seed extract | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Anthocyanin | en_US |
dc.subject.emtree | Antioxidant | en_US |
dc.subject.emtree | Calf thymus DNA | en_US |
dc.subject.emtree | Catechin | en_US |
dc.subject.emtree | Cyanidin | en_US |
dc.subject.emtree | DNA | en_US |
dc.subject.emtree | Phenol derivative | en_US |
dc.subject.emtree | Plant extract | en_US |
dc.subject.emtree | Antioxidant activity | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | DNA damage | en_US |
dc.subject.emtree | Drug determination | en_US |
dc.subject.emtree | Drug structure | en_US |
dc.subject.emtree | Grape | en_US |
dc.subject.emtree | High performance liquid chromatography | en_US |
dc.subject.emtree | Mass fragmentography | en_US |
dc.subject.emtree | Oxidation | en_US |
dc.subject.emtree | Oxidative stress | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Bovine | en_US |
dc.subject.emtree | Chemistry | en_US |
dc.subject.emtree | DNA damage | en_US |
dc.subject.emtree | Drug effects | en_US |
dc.subject.emtree | Mass fragmentography | en_US |
dc.subject.emtree | Plant seed | en_US |
dc.subject.emtree | Procedures | en_US |
dc.subject.emtree | Tandem mass spectrometry | en_US |
dc.subject.emtree | Vitis | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anthocyanins | en_US |
dc.subject.mesh | Antioxidants | en_US |
dc.subject.mesh | Catechin | en_US |
dc.subject.mesh | Cattle | en_US |
dc.subject.mesh | DNA | en_US |
dc.subject.mesh | DNA damage | en_US |
dc.subject.mesh | Gas chromatography-mass spectrometry | en_US |
dc.subject.mesh | Phenols | en_US |
dc.subject.mesh | Plant extracts | en_US |
dc.subject.mesh | Seeds | en_US |
dc.subject.mesh | Tandem mass spectrometry | en_US |
dc.subject.mesh | Vitis | en_US |
dc.subject.scopus | Grape Pomace; Antioxidant; Vitis | en_US |
dc.subject.wos | Biochemical research methods | en_US |
dc.subject.wos | Chemistry, analytical | en_US |
dc.title | Investigation of antioxidant ability of grape seeds extract to prevent oxidatively induced DNA damage by gas chromatography-tandem mass spectrometry | en_US |
dc.type | Article | en_US |
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