Association of breast cancer and cytokine gene polymorphism in Turkish women

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dc.contributor.authorGönüllü, Güzin
dc.contributor.authorBaştürk, Bilkay
dc.contributor.buuauthorEvrensel, Türkkan
dc.contributor.buuauthorOral, Barbaros
dc.contributor.buuauthorGözkaman, Ayşe
dc.contributor.buuauthorManavoğlu, Osman
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Immünoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid6603942124tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.contributor.scopusid9633205800tr_TR
dc.contributor.scopusid6602587152tr_TR
dc.date.accessioned2022-08-19T06:51:37Z
dc.date.available2022-08-19T06:51:37Z
dc.date.issued2007-11
dc.description.abstractObjective: To investigate the association of cytokine gene polymorphism with the development of breast cancer. Methods: The study was carried out in Uludag University Medical School, Bursa, Turkey. The study included 38 patients with breast cancer admitted to the Medical Oncology outpatient clinic, and 24 healthy controls, age and sex matched, from the Internal Medicine Department between 2004 and 2005. All genotyping of tumor necrosis factor-cc (TNF-alpha), tumor growth factor-beta 1 (TGF-beta 1), interleukin (IL)-10, IL-6, and interferon-gamma (IFN-gamma) experiments were performed using polymerase chain reaction sequence-specific primers. Results: The frequencies of IL-6-174GC genotype and IL-10 (-1082, -819, -592) GCC/ATA haplotype were significantly higher in the patient group (p=0.0008) when compared with controls (p=0.020). Significantly lower frequencies of IL-10 (-1082,-819,-592) ACC/ATA haplotype were observed in the patient group in comparison to the controls (p=0.026). The distribution of IFN-gamma +874, TNF-a 308, and TGF-beta 1 codon 10-25 genotypes failed to show any statistical significant association with the development of breast cancer. Conclusion: Our data suggest that IL-10 (-1082, -819, -592) GCC/ATA haplotype and IL-6-174 GC genotype seem to be potential risk factors for the development of breast cancer. The presence of IL-10ACC/ATA haplotype may be protective for the oncogenesis of breast cancer.en_US
dc.identifier.citationGönüllü, G. vd. (2007). "Association of breast cancer and cytokine gene polymorphism in Turkish women". Saudi Medical Journal, 28(11), 1728-1733.en_US
dc.identifier.endpage1733tr_TR
dc.identifier.issn0379-5284
dc.identifier.issue11tr_TR
dc.identifier.pubmed17965799tr_TR
dc.identifier.scopus2-s2.0-37049032399tr_TR
dc.identifier.startpage1728tr_TR
dc.identifier.urihttps://smj.org.sa/content/28/11/1728
dc.identifier.urihttps://smj.org.sa/content/smj/28/11/1728.full.pdf
dc.identifier.urihttp://hdl.handle.net/11452/28272
dc.identifier.volume28tr_TR
dc.identifier.wos000251430800020tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSaudi Medical Journalen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPromoter polymorphismen_US
dc.subjectGrowth-factorsen_US
dc.subjectRisken_US
dc.subjectInterleukin-10en_US
dc.subjectSusceptibilityen_US
dc.subjectIl-10en_US
dc.subjectExpressionen_US
dc.subjectSurvivalen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBreast canceren_US
dc.subject.emtreeBreast carcinogenesisen_US
dc.subject.emtreeCancer adjuvant therapyen_US
dc.subject.emtreeCancer hormone therapyen_US
dc.subject.emtreeCodonen_US
dc.subject.emtreeHospital admissionen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGenetic polymorphismen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHaplotypeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInterleukin 10en_US
dc.subject.emtreeMastectomyen_US
dc.subject.emtreeOutpatient departmenten_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeCytokineen_US
dc.subject.emtreeGamma interferonen_US
dc.subject.emtreeHormoneen_US
dc.subject.emtreeInterleukin 6en_US
dc.subject.emtreeTransforming growth factor beta1en_US
dc.subject.emtreeTumor necrosis factor alphaen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBreast neoplasmsen_US
dc.subject.meshCodonen_US
dc.subject.meshPolymorphism, geneticen_US
dc.subject.meshCytokinesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshTurkeyen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-10en_US
dc.subject.meshInterleukin-6en_US
dc.subject.meshMiddle ageden_US
dc.subject.meshTransforming growth factor betaen_US
dc.subject.meshTumor necrosis factor-alphaen_US
dc.subject.scopusInterleukin-10; Restriction Fragment Length Polymorphisms; Polymorphismen_US
dc.subject.wosMedicine, general & internalen_US
dc.titleAssociation of breast cancer and cytokine gene polymorphism in Turkish womenen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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