Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?

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dc.contributor.authorKaya, Hakan
dc.contributor.authorDesdicioğlu, Raziye
dc.contributor.authorSezik, Mekin
dc.contributor.authorÖzkaya, Okan
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorYımaztepe, Arzu
dc.contributor.buuauthorDemirci, Meral
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.researcheridK-5792-2018tr_TR
dc.contributor.scopusid6602927353tr_TR
dc.contributor.scopusid8606136100tr_TR
dc.contributor.scopusid18534643800tr_TR
dc.date.accessioned2021-12-20T09:06:17Z
dc.date.available2021-12-20T09:06:17Z
dc.date.issued2008-03
dc.description.abstractThe aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.en_US
dc.description.sponsorshipSüleyman Demirel Üniversitesitr_TR
dc.identifier.citationKaya, H. vd. (2008). ''Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?''. Fertility and Sterility, 89(3), 732-735.en_US
dc.identifier.endpage735tr_TR
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue3tr_TR
dc.identifier.pubmed17517398tr_TR
dc.identifier.scopus2-s2.0-40249114895tr_TR
dc.identifier.startpage732tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2007.03.065
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0015028207007947
dc.identifier.urihttp://hdl.handle.net/11452/23409
dc.identifier.volume89tr_TR
dc.identifier.wos000254026700037tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalFertility and Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOocyte apoptosisen_US
dc.subjectActivationen_US
dc.subjectSurvivalen_US
dc.subjectChemotherapyen_US
dc.subjectFolliclesen_US
dc.subjectGranulosaen_US
dc.subjectCaspase-3en_US
dc.subjectAciden_US
dc.subjectObstetrics & gynecologyen_US
dc.subjectReproductive biologyen_US
dc.subject.emtreeCyclophosphamideen_US
dc.subject.emtreeCytotoxinen_US
dc.subject.emtreeDrug metaboliteen_US
dc.subject.emtreeSphingosine 1 phosphateen_US
dc.subject.emtreeAnimal cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCell survivalen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOvaryen_US
dc.subject.emtreeOvary diseaseen_US
dc.subject.emtreeOvary follicleen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtectionen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeWhole body radiationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic agents, alkylatingen_US
dc.subject.meshApoptosisen_US
dc.subject.meshCyclophosphamideen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshFemaleen_US
dc.subject.meshInjections, intraperitonealen_US
dc.subject.meshLysophospholipidsen_US
dc.subject.meshOvarian diseasesen_US
dc.subject.meshOvarian follicleen_US
dc.subject.meshOvulation inductionen_US
dc.subject.meshRadiation injuries, experimentalen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshSphingosineen_US
dc.subject.meshWhole-body irradiationen_US
dc.subject.scopusFertility Preservation; Ovulation Induction; Vitrificationen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.subject.wosReproductive biologyen_US
dc.titleDoes sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?en_US
dc.typeEditorial Material
dc.wos.quartileQ1en_US

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