Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
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Date
2008-03
Authors
Kaya, Hakan
Desdicioğlu, Raziye
Sezik, Mekin
Özkaya, Okan
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.
Description
Keywords
Oocyte apoptosis, Activation, Survival, Chemotherapy, Follicles, Granulosa, Caspase-3, Acid, Obstetrics & gynecology, Reproductive biology
Citation
Kaya, H. vd. (2008). ''Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?''. Fertility and Sterility, 89(3), 732-735.