Serum butyrylcholinesterase and paraoxonase 1 in a canine model of endotoxemia: Effects of choline administration

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dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorTecles, Fernando
dc.contributor.authorCeron, Jose J.
dc.contributor.buuauthorKocatürk, Meriç
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-9836-0749tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.scopusid36437200800tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid35944810500tr_TR
dc.date.accessioned2022-03-23T13:24:06Z
dc.date.available2022-03-23T13:24:06Z
dc.date.issued2012-10
dc.description.abstractButyrylcholinesterase (BChE) and paraoxonase 1 (PON1) are two serum enzymes synthesized by the liver that are related with inflammation. The main objectives of this study were to determine changes in serum BChE and PON1 by using a canine model of endotoxemia, and to evaluate whether choline alters BChE and PON1 activities during inflammation. For this purpose, a total of 20 mongrel dogs were divided into four groups: control, choline (C), lipopolysaccharide (LPS), and LPS + C. Dogs in the control group were injected with 0.9% NaCl (0.2 ml/kg, i.v.). Dogs in C and LPS + C groups received choline chloride (20 mg/kg, i.v., three times with 4 h intervals). Endotoxin was injected (0.02 mg/kg, i.v., once) to the dogs of LPS and LPS + C groups. Statistically significant decreases in BChE and PON1 activities in LPS group were detected 24 and 48 h post injection, respectively. No statistically significant changes in BChE and PON1 activities at different times were detected in control, C, or LPS + C groups. In conclusion, the data obtained in present study revealed a decrease in serum BChE and PON1 activities in dogs during experimentally induced endotoxemia and that choline administration attenuates these changes.en_US
dc.identifier.citationTvarijonaviciute, A. vd. (2012). "Serum butyrylcholinesterase and paraoxonase 1 in a canine model of endotoxemia: Effects of choline administration". Research in Veterinary Science, 93(2), 668-674.en_US
dc.identifier.endpage674tr_TR
dc.identifier.issn0034-5288
dc.identifier.issn1532-2661
dc.identifier.issue2tr_TR
dc.identifier.pubmed22000805tr_TR
dc.identifier.scopus2-s2.0-84863879483tr_TR
dc.identifier.startpage668tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.rvsc.2011.09.010
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0034528811003699
dc.identifier.urihttp://hdl.handle.net/11452/25310
dc.identifier.volume93tr_TR
dc.identifier.wos000306864900020tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalResearch in Veterinary Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak109O660tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVeterinary sciencesen_US
dc.subjectBChEen_US
dc.subjectCholineen_US
dc.subjectDogen_US
dc.subjectLipopolysaccharideen_US
dc.subjectPon1en_US
dc.subjectS1rsen_US
dc.subjectCdp-cholineen_US
dc.subjectWhole-blooden_US
dc.subjectInvolvementen_US
dc.subjectMetabolitesen_US
dc.subjectInsulinen_US
dc.subjectSepsisen_US
dc.subjectInhibitionen_US
dc.subjectReceptorsen_US
dc.subjectDecreaseen_US
dc.subjectRatsen_US
dc.subject.emtreeAryldialkylphosphatase 1en_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeCholinesteraseen_US
dc.subject.emtreeEndotoxinen_US
dc.subject.emtreeLipopolysaccharideen_US
dc.subject.emtreeAcute phase responseen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDogen_US
dc.subject.emtreeEndotoxemiaen_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeEnzyme blood levelen_US
dc.subject.emtreeEnzyme synthesisen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAryldialkylphosphataseen_US
dc.subject.meshBody temperatureen_US
dc.subject.meshButyrylcholinesteraseen_US
dc.subject.meshCholineen_US
dc.subject.meshDog diseasesen_US
dc.subject.meshDogsen_US
dc.subject.meshEndotoxemiaen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene expression regulation, enzymologicen_US
dc.subject.meshLipopolysaccharidesen_US
dc.subject.meshMaleen_US
dc.subject.meshRespirationen_US
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.wosVeterinary sciencesen_US
dc.titleSerum butyrylcholinesterase and paraoxonase 1 in a canine model of endotoxemia: Effects of choline administrationen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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