Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid

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dc.contributor.buuauthorAydın, Cenk
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3090-0099tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.scopusid7005426982tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.date.accessioned2022-04-19T10:59:59Z
dc.date.available2022-04-19T10:59:59Z
dc.date.issued2008-06
dc.description.abstractIn the current study, we aimed to determine the cardiovascular effects of arachidonic acid and peripheral mechanisms mediated these effects in normotensive conscious rats. Studies were performed in male Sprague Dawley rats. Arachidonic acid was injected intracerebroventricularly (i.c.v.) at the doses of 75, 150 or 300 mu g and it caused dose- and time-dependent increase in mean arterial pressure and decrease in heart rate in normal conditions. Maximal effects were observed 10 min after 150 and 300 mu g dose of arachidonic acid and lasted within 30 min. In order to evaluate the role of main peripheral hormonal mechanisms in those cardiovascular effects, plasma adrenaline, noradrenaline, vasopressin levels and renin activity were measured after arachidonic acid (150 mu g; i.c.v.) injection. Centrally injected arachidonic acid increased plasma levels of all these hormones and renin activity. Intravenous pretreatments with prazosin (0.5 mg/kg), an alpha(1) adrenoceptor antagonist, [beta-mercapto-beta,beta-cyclopentamethylenepropionyl(1), O-Me-Tyr(2)-Arg(8)]-vasopressin (10 mu g/kg), a vasopressin V-1 receptor antagonist, or saralasin (250 mu g/kg), an angiotensin II receptor antagonist, partially blocked the pressor response to arachidonic acid (150 mu g; i.c.v.) while combined administration of these three antagonists completely abolished the effect. Moreover, both individual and combined antagonist pretreatments fully blocked the bradycardic effect of arachidonic acid. In conclusion, our findings show that centrally administered arachidonic acid increases mean arterial pressure and decreases heart rate in normotensive conscious rats and the increases in plasma adrenaline, noradrenaline, vasopressin levels and renin activity appear to mediate the cardiovascular effects of the drug.en_US
dc.identifier.citationAydın, C. ve Yalçın, M. (2008). "Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid". Prostaglandins Leukotrienes and Essential Fatty Acids, 78(6), 361-368.en_US
dc.identifier.endpage368tr_TR
dc.identifier.issn0952-3278
dc.identifier.issn1532-2823
dc.identifier.issue6tr_TR
dc.identifier.pubmed18571395tr_TR
dc.identifier.scopus2-s2.0-46049100181tr_TR
dc.identifier.startpage361tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.plefa.2008.04.007
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0952327808000549
dc.identifier.urihttp://hdl.handle.net/11452/25859
dc.identifier.volume78tr_TR
dc.identifier.wos000258022300005tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.journalProstaglandins Leukotrienes and Essential Fatty Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitakKARİYER 104V116tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSympatho-adrenomedullary outflowen_US
dc.subjectCentral cholinergic systemen_US
dc.subjectHemorrhaged hypotensive ratsen_US
dc.subjectNormotensive conscious ratsen_US
dc.subjectThromboxane a2 analogen_US
dc.subjectVasopressin secretionen_US
dc.subjectInjected u-46619en_US
dc.subjectBlood-pressureen_US
dc.subjectActivationen_US
dc.subjectMelittinen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectCell biologyen_US
dc.subjectEndocrinology & metabolismen_US
dc.subject.emtree[Beta mercapto beta,beta cyclopentamethylenepropionyl 2 (o methyltyrosine) 8 arginine] vasopressinen_US
dc.subject.emtreeAdrenalinen_US
dc.subject.emtreeArachidonic aciden_US
dc.subject.emtreeNoradrenalin blood levelen_US
dc.subject.emtreePrazosinen_US
dc.subject.emtreeReninen_US
dc.subject.emtreeSaralasinen_US
dc.subject.emtreeVasopressinen_US
dc.subject.emtreeVasopressin receptor antagonisten_US
dc.subject.emtreeAdrenalin blood levelen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood pressure regulationen_US
dc.subject.emtreeBradycardiaen_US
dc.subject.emtreeCardiovascular effecten_US
dc.subject.emtreeClinical evaluationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug effectDen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeHormone actionen_US
dc.subject.emtreeHormone blood levelen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMean arterial pressureen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeNoradrenalin blood levelen_US
dc.subject.emtreePlasma renin activityen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSasopressin blood levelen_US
dc.subject.meshAdrenergic alpha-antagonistsen_US
dc.subject.meshAngiotensin II type 1 receptor blockersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArachidonic aciden_US
dc.subject.meshArginine vasopressinen_US
dc.subject.meshBlood pressureen_US
dc.subject.meshCardiovascular systemen_US
dc.subject.meshEpinephrineen_US
dc.subject.meshHeart Rateen_US
dc.subject.meshHormone antagonistsen_US
dc.subject.meshInjections, intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshNorepinephrineen_US
dc.subject.meshPrazosinen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshReninen_US
dc.subject.meshSaralasinen_US
dc.subject.meshVasopressinsen_US
dc.subject.scopusHistamine H4 Receptors; Thioperamide; Chlorpheniramine Maleateen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.titlePeripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic aciden_US
dc.typeArticle
dc.wos.quartileQ4en_US

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