Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients

dc.contributor.authorYavuz, Dilek Gogas
dc.contributor.authorKeskin, Lezan
dc.contributor.authorSert, Murat
dc.contributor.authorYazıcı, Dilek
dc.contributor.authorŞahin, İbrahim
dc.contributor.authorYüksel, Meral
dc.contributor.authorDeyneli, Oğuzhan
dc.contributor.authorAydın, Hasan
dc.contributor.authorAkalın, Sema
dc.contributor.buuauthorKıyıcı, Sinem
dc.contributor.buuauthorTuncel, Ercan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Diyabet ve Metabolizma Anabilim Dalı.tr_TR
dc.contributor.scopusid12753880400tr_TR
dc.contributor.scopusid7006929833tr_TR
dc.date.accessioned2022-11-09T06:37:27Z
dc.date.available2022-11-09T06:37:27Z
dc.date.issued2011-12
dc.description.abstractPrevious studies have suggested an influence of vitamin D receptor alleles on bone metabolism and on susceptibility to type 1 diabetes mellitus in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in relation to biochemical bone turnover parameters and bone densitometry measurements in a group of Turkish type 1 diabetic patients. One hundred and seventeen patients (M/F 57/60, 27.6 +/- A 7.3 y duration of diabetes 8.1 +/- A 6.3 y) and 134 healthy controls (M/F 61/73, 26.2 +/- A 5.3 y) were included in the study. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DEXA). The vitamin D receptor gene (VDR) polymorphisms FokI, Bsm1, Apa1, and Taq1 were examined using a PCR-based restriction analysis. Serum levels of calcium, phosphor osteocalcin, intact parathyroid hormone, and C telopeptide were measured. Vitamin D receptor Bsm1 Fok1, Apa1, and Taq1 genotype distributions were not different between patient with diabetes and control groups. BMD was 0.77 +/- A 0.2 g/cm(2) vs. 0.97 +/- A 0.2 g/cm(2) (P = 0.0001) for the femur, 1.0 +/- A 0.1 g/cm(2) vs. 1.13 +/- A 0.1 g/cm(2) (P = 0.001) for type 1 diabetic patients and controls. Bone turnover markers were significantly lower in type 1 diabetic group. BMD measurements and bone metabolic markers were not different between the genotypes in either the patient with diabetes or the controls. The VDR gene polymorphisms, Bsm1, Fok 1, Apa1, and Taq1 showed no influence on bone metabolism in our group of type 1 diabetic patients.en_US
dc.description.sponsorshipTurkish Diabetes Foundationen_US
dc.identifier.citationYavuz, D. G. vd. (2011). "Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients". Acta Diabetologica, 48(4), 329-336.en_US
dc.identifier.endpage336tr_TR
dc.identifier.issn0940-5429
dc.identifier.issn1432-5233
dc.identifier.issue4tr_TR
dc.identifier.pubmed21538164tr_TR
dc.identifier.scopus2-s2.0-84355166778tr_TR
dc.identifier.startpage329tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00592-011-0284-y
dc.identifier.urihttps://link.springer.com/article/10.1007/s00592-011-0284-y
dc.identifier.urihttp://hdl.handle.net/11452/29435
dc.identifier.volume48tr_TR
dc.identifier.wos000297515600009tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalActa Diabetologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectType 1 diabetesen_US
dc.subjectVitamin Den_US
dc.subjectVitamin D receptor gene polymorphismsen_US
dc.subjectBone mineral densityen_US
dc.subjectAssociationen_US
dc.subjectPopulationen_US
dc.subjectSusceptibilityen_US
dc.subjectOsteoporosisen_US
dc.subjectPrevalenceen_US
dc.subjectOsteopeniaen_US
dc.subjectMellitusen_US
dc.subjectHealthen_US
dc.subjectOnseten_US
dc.subject.emtree25 hydroxyvitamin Den_US
dc.subject.emtreeCalciumen_US
dc.subject.emtreeCarboxy terminal telopeptideen_US
dc.subject.emtreeCreatinineen_US
dc.subject.emtreeGlucoseen_US
dc.subject.emtreeOsteocalcinen_US
dc.subject.emtreeParathyroid hormoneen_US
dc.subject.emtreeVitamin D receptoren_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBone densitometryen_US
dc.subject.emtreeBone densityen_US
dc.subject.emtreeBone metabolismen_US
dc.subject.emtreeBone turnoveren_US
dc.subject.emtreeCalcium blood levelen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCreatinine blood levelen_US
dc.subject.emtreeCross-sectional studyen_US
dc.subject.emtreeDisease durationen_US
dc.subject.emtreeEthnic groupen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGene locationen_US
dc.subject.emtreeGenetic polymorphismen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeHormone blood levelen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInsulin dependent diabetes mellitusen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMusculoskeletal system parametersen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeProtein localizationen_US
dc.subject.emtreeVitamin blood levelen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBone densityen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshDeoxyribonucleases, type II site-specificen_US
dc.subject.meshDiabetes mellitus, type 1en_US
dc.subject.meshDNA restriction enzymesen_US
dc.subject.meshEuropean continental ancestry groupen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPolymorphism, restriction fragment lengthen_US
dc.subject.meshReceptors, calcitriolen_US
dc.subject.meshTurkeyen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusCalcitriol Receptors; Insulin Dependent Diabetes Mellitus; Vitamin Den_US
dc.subject.wosEndocrinology & metabolismen_US
dc.titleVitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patientsen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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