Effects of long-term cyclosporine a therapy on renal functions in Behcet's disease

dc.contributor.buuauthorSarıcaoğlu, Hayriye
dc.contributor.buuauthorBaşkan, Emel Bülbül
dc.contributor.buuauthorCıkman, Toker, S.
dc.contributor.buuauthorDilek, K.
dc.contributor.buuauthorTunalı, Şükran
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Deri ve Zührevi Hastalıklar Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.scopusid6603722836tr_TR
dc.contributor.scopusid6602518817tr_TR
dc.contributor.scopusid36643653000tr_TR
dc.contributor.scopusid6603823242tr_TR
dc.contributor.scopusid7004191748tr_TR
dc.date.accessioned2023-10-24T10:37:43Z
dc.date.available2023-10-24T10:37:43Z
dc.date.issued2004
dc.description.abstractCyclosporin A (CsA), one of the most extensively investigated immunomodulatory agents is widely used today in the treatment of various immunologically triggered dermatologic disorders. The immunologic basis for the therapeutic action of CsA depends on the suppression of lymphokine production by T Cells. Due to its immunologic effects, this drug is also commonly preferred in Behcet's disease, especially with neurologic and ocular involvement. Since the course of this chronic disease presents remissions and exacerbations, drug therapy should be long term. Studies on the safety of long-term use of CsA in dermatologic diseases are limited. In this study, we aimed to evaluate the long-term use of CsA in Behcet's disease without renal involvement. A total of 19 patients with ocular Behcet's disease receiving CsA therapy for at least 1 year were included in this retrospective study. Changes in the parameters of renal function (creatinine clearance, creatinine level in serum), other adverse effects and their relation with cumulative CsA dosage were evaluated. The duration of CsA therapy and total dosage were not found to have a significant effect on the parameters of renal function, but, depending on clinical observations, the adverse effects seem to increase in the long term. We conclude that our results on renal function should be supported by renal biopsies.en_US
dc.identifier.citationSarıcaoğlu, H. vd. (2004). “Effects of long-term cyclosporine a therapy on renal functions in Behcet's disease”. International Journal of Tissue Reactions- Experimental and Clinical Aspects, 26(3-4), 93-96.en_US
dc.identifier.endpage96tr_TR
dc.identifier.issn0250-0868
dc.identifier.issue3-4tr_TR
dc.identifier.pubmed15648441tr_TR
dc.identifier.scopus2-s2.0-11344277624tr_TR
dc.identifier.startpage93tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/34548
dc.identifier.volume26tr_TR
dc.identifier.wos000226689600004tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherBioscience Ediprinten_US
dc.relation.journalInternational Journal of Tissue Reactions- Experimental and Clinical Aspectsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell biologyen_US
dc.subjectPsoriasisen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAggressivenessen_US
dc.subject.emtreeAmenorrheaen_US
dc.subject.emtreeAnemiaen_US
dc.subject.emtreeAnorexiaen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBehcet diseaseen_US
dc.subject.emtreeBurning sensationen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeClinical protocolen_US
dc.subject.emtreeCreatinine blood levelen_US
dc.subject.emtreeCreatinine clearanceen_US
dc.subject.emtreeDiarrheaen_US
dc.subject.emtreeDigestive system function disorderen_US
dc.subject.emtreeDrug dose regimenen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug safetyen_US
dc.subject.emtreeDrug useen_US
dc.subject.emtreeDyspepsiaen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGingiva bleedingen_US
dc.subject.emtreeGingiva hyperplasiaen_US
dc.subject.emtreeGynecologic diseaseen_US
dc.subject.emtreeHair lossen_US
dc.subject.emtreeHeadacheen_US
dc.subject.emtreeHematologic diseaseen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHypertensionen_US
dc.subject.emtreeHypertrichosisen_US
dc.subject.emtreeJaundiceen_US
dc.subject.emtreeKidney functionen_US
dc.subject.emtreeLeukemiaen_US
dc.subject.emtreeLong term careen_US
dc.subject.emtreeMalaiseen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMalignant neoplastic diseaseen_US
dc.subject.emtreeMenstruation disorderen_US
dc.subject.emtreeMyalgiaen_US
dc.subject.emtreeNauseaen_US
dc.subject.emtreeNephrotoxicityen_US
dc.subject.emtreeNeurologic diseaseen_US
dc.subject.emtreeParesthesiaen_US
dc.subject.emtreePhotophobiaen_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.emtreeSide effecten_US
dc.subject.emtreeTinnitusen_US
dc.subject.emtreeVertigoen_US
dc.subject.emtreeVomitingen_US
dc.subject.emtreeBehcet syndromeen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeKidneyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeAzathioprineen_US
dc.subject.emtreeColchicineen_US
dc.subject.emtreeCorticosteroiden_US
dc.subject.emtreeCreatinineen_US
dc.subject.emtreeCyclophosphamideen_US
dc.subject.emtreeCyclosporin Aen_US
dc.subject.emtreeMethylprednisoloneen_US
dc.subject.emtreeMycophenolic acid 2 morpholinoethyl esteren_US
dc.subject.emtreeCyclosporinen_US
dc.subject.emtreeImmunosuppressive agenten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxiaen_US
dc.subject.meshArginineen_US
dc.subject.meshHypertension, pulmonaryen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane potentialsen_US
dc.subject.meshMyocytes, smooth muscleen_US
dc.subject.meshPatch-clamp techniquesen_US
dc.subject.meshPotassium channels, calcium-activateden_US
dc.subject.meshPotassium channels, voltage-gateden_US
dc.subject.meshPulmonary arteryen_US
dc.subject.meshRandom allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.scopusPhototherapy; Pustulosis Palmoplantaris; Etretinen_US
dc.subject.wosCell biologyen_US
dc.titleEffects of long-term cyclosporine a therapy on renal functions in Behcet's diseaseen_US
dc.typeArticle

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