Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

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dc.contributor.buuauthorİsbil, Naciye Büyükcoşkun
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.buuauthorGüleç, Gamze Gül
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridAAH-1692-2021tr_TR
dc.contributor.scopusid55665951400tr_TR
dc.contributor.scopusid6602752303tr_TR
dc.contributor.scopusid6602676331tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.date.accessioned2022-01-05T07:07:17Z
dc.date.available2022-01-05T07:07:17Z
dc.date.issued2001-06
dc.description.abstractIn the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 μg) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 μg, icv), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 μg, icv), was administered 3 rain before choline. Twenty-five μg captopril did not block the pressor effect of choline, while 50 μg captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats.en_US
dc.identifier.citationİşbil, B. N. vd. (2001). "Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline". Brazilian Journal of Medical and Biological Research, 34(6), 815-820.en_US
dc.identifier.endpage820tr_TR
dc.identifier.issn0100-879X
dc.identifier.issue6tr_TR
dc.identifier.pubmed11378673tr_TR
dc.identifier.scopus2-s2.0-0034952686tr_TR
dc.identifier.startpage815tr_TR
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2001000600018
dc.identifier.urihttps://www.scielo.br/j/bjmbr/a/B7ZmggtDxTPVYkTQVTkZqCh/?lang=en
dc.identifier.urihttp://hdl.handle.net/11452/23858
dc.identifier.volume34tr_TR
dc.identifier.wos000169443400018tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.journalBrazilian Journal of Medical and Biological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlood pressureen_US
dc.subjectCaptoprilen_US
dc.subjectCholineen_US
dc.subjectIntracerebroventricular cholineen_US
dc.subjectSpontaneously hypertensive ratsen_US
dc.subjectRenin-angiotensin systemen_US
dc.subjectConscious rabbitsen_US
dc.subjectNormotensive ratsen_US
dc.subjectBrainen_US
dc.subjectHemorrhageen_US
dc.subjectStimulationen_US
dc.subjectCarbacholen_US
dc.subjectDrinkingen_US
dc.subjectLife sciences & biomedicine - other topicsen_US
dc.subjectResearch & experimental medicineen_US
dc.subject.emtreeAngiotensinen_US
dc.subject.emtreeDipeptidyl carboxypeptidase inhibitoren_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeCaptoprilen_US
dc.subject.emtreeRenin angiotensin aldosterone systemen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeLosartanen_US
dc.subject.emtreeBlood pressure regulationen_US
dc.subject.emtreeRamiprilen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeRessureen_US
dc.subject.emtreeCholinergic stimulationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.scopusPregnanolone; Orexins; Scotophaseen_US
dc.subject.wosBiologyen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.titleCentral injection of captopril inhibits the blood pressure response to intracerebroventricular cholineen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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