Intravenous administration of choline or CDP-choline improves platelet count and platelet closure times in endotoxin-treated dogs

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dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.buuauthorİlcol, Yeşim Özarda
dc.contributor.buuauthorTorun, Serhat
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-9836-0749tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridA-9637-2008tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.date.accessioned2021-09-13T13:17:40Z
dc.date.available2021-09-13T13:17:40Z
dc.date.issued2006
dc.description.abstractThis study was performed to assess the effects of intravenous choline chloride and cytidine-5'-diphosphate choline (CDP-choline) treatments on circulating platelet, white blood cell, and red blood cell counts and platelet functions in response to endotoxin. Saline (0.2 mL/kg), choline chloride (20 mg/kg), or CDP-choline (70 mg/kg) were given intravenously three times at 4-h intervals, and endotoxemia was induced by endotoxin (E. coli 055:B5, 20 mu g/kg) infusion, 5 min after the first treatment. Blood samples were collected before and at multiple time points after the challenge, for a panel of hematologic parameters and platelet closure times measured by PFA-100 (TM). In saline-treated dogs, circulating platelet counts decreased by 85% (P < 0.001) at 0.5 h and remained low by 36%-80% (P < 0.5-0.001) 1-12 h after endotoxin. Circulating WBC counts decreased by 80%-90% (P < 0.001) at 0.5-2 h, and increased (P < 0.001) by 190% 12 h after the endotoxin. In response to endotoxin, RBCs increased by 10%-13% (P < 0.05) at 1-12 h. Endotoxin-induced decline in circulating platelets was attenuated at 0.5 h (P < 0.05--0.01) and reversed at 1-12 h (P < 0.05-0.001) by choline. Platelet closure times were shortened from 81 +/- 10 s and 135 +/- 10 s to 29 +/- 5 s (P < 0.001) and 60 +/- 3 s (P < 0.001) at 0.5 h, and prolonged (P < 0.001) at 1-8 h after endotoxin induction. Endotoxin-induced shortening in platelet closure times was attenuated (P < 0.05) and blocked (P < 0.01) by choline and CDP-choline, respectively. These results showed that choline and CDP-choline treatments improved circulating platelet counts and platelet function during endotoxemia in dogs.en_US
dc.identifier.citationYılmaz, Z. vd. (2006). ''Intravenous administration of choline or CDP-choline improves platelet count and platelet closure times in endotoxin-treated dogs''. Shock, 25(1), 73-79.en_US
dc.identifier.endpage79tr_TR
dc.identifier.issn1073-2322
dc.identifier.issn1540-0514
dc.identifier.issue1tr_TR
dc.identifier.pubmed16369190tr_TR
dc.identifier.scopus2-s2.0-33646365090tr_TR
dc.identifier.startpage73tr_TR
dc.identifier.urihttps://doi.org/10.1097/01.shk.0000185796.04589.15
dc.identifier.urihttps://journals.lww.com/shockjournal/Fulltext/2006/01000/INTRAVENOUS_ADMINISTRATION_OF_CHOLINE_OR.13.aspx
dc.identifier.urihttp://hdl.handle.net/11452/21914
dc.identifier.volume25tr_TR
dc.identifier.wos000234472000013tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williamsen_US
dc.relation.journalShocken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectHematologyen_US
dc.subjectSurgeryen_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subjectCDP-cholineen_US
dc.subjectCholineen_US
dc.subjectDogen_US
dc.subjectEndotoxemiaen_US
dc.subjectPFA-100en_US
dc.subjectPlateleten_US
dc.subjectRolesen_US
dc.subjectAugmentsen_US
dc.subjectRaten_US
dc.subjectShocksen_US
dc.subjectCytidineen_US
dc.subjectFunction analyzeren_US
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.wosPeripheral vascular diseaseen_US
dc.subject.wosSurgeryen_US
dc.subject.wosHematologyen_US
dc.subject.wosCritical care medicineen_US
dc.titleIntravenous administration of choline or CDP-choline improves platelet count and platelet closure times in endotoxin-treated dogsen_US
dc.typeArticle
dc.wos.quartileQ2en_US
dc.wos.quartileQ1 (Surgery)en_US

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