Immunohistochemical localization of insulin-like growth factor-I receptor (IGF-IR) in the developing and mature rat testes
dc.contributor.author | Yağcı, Artay | |
dc.contributor.buuauthor | Zık, Berrin | |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji-Embriyoloji Anabilim Dalı. | tr_TR |
dc.contributor.researcherid | AAH-9810-2021 | tr_TR |
dc.contributor.scopusid | 6507763192 | tr_TR |
dc.date.accessioned | 2021-12-08T05:48:44Z | |
dc.date.available | 2021-12-08T05:48:44Z | |
dc.date.issued | 2006-10 | |
dc.description.abstract | It has been suggested that insulin-like growth factor-I (IGF-I) plays an important role in the regulation of spermatogenesis in the testes. Its signal is mediated predominantly by the IGF-I receptor (IGF-IR). Signalling through IGF-IR has been shown to have a potent survival function. IGF-IR, a transmembrane tyrosine kinase, is widely expressed across many cell types. In this study, we demonstrated the distribution of IGF-IR in testes of differently aged rats. Anti-IGF-IR is a rabbit polyclonal antibody raised against a peptide mapping at the carboxy terminus of the IGF-IR of human origin. Testicular specimens were fixed in Bouin's solution and embedded in paraffin. The paraffin-embedded sections were processed for standard immunohistochemistry by the labelled streptavidin-biotin technique. At postnatal day 19, IGF-IR immunoreactivity was seen moderately in spermatogonia, and slightly both in leptotene and zygotene primary spermatocytes. At postnatal day 35, immunoreactivity was seen slightly both in the pachytene primary spermatocytes and Leydig cells. Although there was intense immunoreactivity in the Leydig cells and in the elongated spermatids on days 50 and 70, the intensity of reaction was decreased in the elongated spermatids in the 10th month. Our results suggest that IGF-IR may play significant roles in testicular function and germ cell development. | en_US |
dc.identifier.citation | Yağcı, A. ve Zık, B. (2006). ''Immunohistochemical localization of insulin-like growth factor-I receptor (IGF-IR) in the developing and mature rat testes''. Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia, 35(5), 305-309. | en_US |
dc.identifier.endpage | 309 | tr_TR |
dc.identifier.issn | 0340-2096 | |
dc.identifier.issn | 1439-0264 | |
dc.identifier.issue | 5 | tr_TR |
dc.identifier.pubmed | 16968249 | tr_TR |
dc.identifier.scopus | 2-s2.0-33748581044 | tr_TR |
dc.identifier.startpage | 305 | tr_TR |
dc.identifier.uri | https://doi.org/10.1111/j.1439-0264.2006.00689.x | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1111/j.1439-0264.2006.00689.x | |
dc.identifier.uri | http://hdl.handle.net/11452/23055 | |
dc.identifier.volume | 35 | tr_TR |
dc.identifier.wos | 000240401600006 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anatomy & morphology | en_US |
dc.subject | Veterinary sciences | en_US |
dc.subject | Oryctolagus cuniculus | en_US |
dc.subject | Spermatogenesis | en_US |
dc.subject | Hormone | en_US |
dc.subject | Factor system | en_US |
dc.subject | Testicular cells | en_US |
dc.subject | Tissue concentrations | en_US |
dc.subject | Leydig-cells | en_US |
dc.subject | Csomatomedin-C | en_US |
dc.subject | Binding-proteins | en_US |
dc.subject | Sertoli cells | en_US |
dc.subject | Messenger-ribonucleic-acid | en_US |
dc.subject.emtree | Somatomedin C receptor | en_US |
dc.subject.emtree | Somatomedin C | en_US |
dc.subject.emtree | Aging | en_US |
dc.subject.emtree | Testis | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Physiology | en_US |
dc.subject.emtree | Metabolism | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Isolation and purification | en_US |
dc.subject.emtree | Immunohistochemistry | en_US |
dc.subject.emtree | Growth, development and aging | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Animal disease | en_US |
dc.subject.mesh | Testis | en_US |
dc.subject.mesh | Receptor, IGF type 1 | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Insulin-like growth factor I | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Aging | en_US |
dc.subject.scopus | Semen; Sperm Concentration; Semen Analysis | en_US |
dc.subject.wos | Anatomy & morphology | en_US |
dc.subject.wos | Veterinary sciences | en_US |
dc.title | Immunohistochemical localization of insulin-like growth factor-I receptor (IGF-IR) in the developing and mature rat testes | en_US |
dc.type | Article | |
dc.wos.quartile | Q4 (Anatomy & morphology) | en_US |
dc.wos.quartile | Q3 (Veterinary sciences) | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: