Immunohistochemical localization of insulin-like growth factor-I receptor (IGF-IR) in the developing and mature rat testes

dc.contributor.authorYağcı, Artay
dc.contributor.buuauthorZık, Berrin
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Histoloji-Embriyoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-9810-2021tr_TR
dc.contributor.scopusid6507763192tr_TR
dc.date.accessioned2021-12-08T05:48:44Z
dc.date.available2021-12-08T05:48:44Z
dc.date.issued2006-10
dc.description.abstractIt has been suggested that insulin-like growth factor-I (IGF-I) plays an important role in the regulation of spermatogenesis in the testes. Its signal is mediated predominantly by the IGF-I receptor (IGF-IR). Signalling through IGF-IR has been shown to have a potent survival function. IGF-IR, a transmembrane tyrosine kinase, is widely expressed across many cell types. In this study, we demonstrated the distribution of IGF-IR in testes of differently aged rats. Anti-IGF-IR is a rabbit polyclonal antibody raised against a peptide mapping at the carboxy terminus of the IGF-IR of human origin. Testicular specimens were fixed in Bouin's solution and embedded in paraffin. The paraffin-embedded sections were processed for standard immunohistochemistry by the labelled streptavidin-biotin technique. At postnatal day 19, IGF-IR immunoreactivity was seen moderately in spermatogonia, and slightly both in leptotene and zygotene primary spermatocytes. At postnatal day 35, immunoreactivity was seen slightly both in the pachytene primary spermatocytes and Leydig cells. Although there was intense immunoreactivity in the Leydig cells and in the elongated spermatids on days 50 and 70, the intensity of reaction was decreased in the elongated spermatids in the 10th month. Our results suggest that IGF-IR may play significant roles in testicular function and germ cell development.en_US
dc.identifier.citationYağcı, A. ve Zık, B. (2006). ''Immunohistochemical localization of insulin-like growth factor-I receptor (IGF-IR) in the developing and mature rat testes''. Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia, 35(5), 305-309.en_US
dc.identifier.endpage309tr_TR
dc.identifier.issn0340-2096
dc.identifier.issn1439-0264
dc.identifier.issue5tr_TR
dc.identifier.pubmed16968249tr_TR
dc.identifier.scopus2-s2.0-33748581044tr_TR
dc.identifier.startpage305tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1439-0264.2006.00689.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1439-0264.2006.00689.x
dc.identifier.urihttp://hdl.handle.net/11452/23055
dc.identifier.volume35tr_TR
dc.identifier.wos000240401600006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Veterinary Medicine Series C: Anatomia Histologia Embryologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnatomy & morphologyen_US
dc.subjectVeterinary sciencesen_US
dc.subjectOryctolagus cuniculusen_US
dc.subjectSpermatogenesisen_US
dc.subjectHormoneen_US
dc.subjectFactor systemen_US
dc.subjectTesticular cellsen_US
dc.subjectTissue concentrationsen_US
dc.subjectLeydig-cellsen_US
dc.subjectCsomatomedin-Cen_US
dc.subjectBinding-proteinsen_US
dc.subjectSertoli cellsen_US
dc.subjectMessenger-ribonucleic-aciden_US
dc.subject.emtreeSomatomedin C receptoren_US
dc.subject.emtreeSomatomedin Cen_US
dc.subject.emtreeAgingen_US
dc.subject.emtreeTestisen_US
dc.subject.emtreeRaten_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeIsolation and purificationen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeGrowth, development and agingen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAnimal diseaseen_US
dc.subject.meshTestisen_US
dc.subject.meshReceptor, IGF type 1en_US
dc.subject.meshRatsen_US
dc.subject.meshMaleen_US
dc.subject.meshInsulin-like growth factor Ien_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAgingen_US
dc.subject.scopusSemen; Sperm Concentration; Semen Analysisen_US
dc.subject.wosAnatomy & morphologyen_US
dc.subject.wosVeterinary sciencesen_US
dc.titleImmunohistochemical localization of insulin-like growth factor-I receptor (IGF-IR) in the developing and mature rat testesen_US
dc.typeArticle
dc.wos.quartileQ4 (Anatomy & morphology)en_US
dc.wos.quartileQ3 (Veterinary sciences)en_US

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