Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats

dc.contributor.buuauthorTaş, Sibel
dc.contributor.buuauthorÇelikler, Serap
dc.contributor.buuauthorZiyanok, Sedef Ayvalık
dc.contributor.buuauthorSarandöl, Emre
dc.contributor.buuauthorDirican, Melahat
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2593-7196tr_TR
dc.contributor.orcid0000-0002-4177-3478tr_TR
dc.contributor.orcid0000-0001-6225-774Xtr_TR
dc.contributor.researcheridABE-6873-2020tr_TR
dc.contributor.researcheridABE-1716-2020tr_TR
dc.contributor.researcheridAAG-6985-2021tr_TR
dc.contributor.researcheridAAH-2767-2021tr_TR
dc.contributor.scopusid7004343411tr_TR
dc.contributor.scopusid8234554800tr_TR
dc.contributor.scopusid15128398000tr_TR
dc.contributor.scopusid55943324800tr_TR
dc.contributor.scopusid6601919847tr_TR
dc.date.accessioned2022-01-03T06:55:29Z
dc.date.available2022-01-03T06:55:29Z
dc.date.issued2011-03
dc.description.abstractThis study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus.en_US
dc.identifier.citationTaş, S. vd. (2011). "Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats". Cell Biochemistry and Function, 29(2), 108-113.en_US
dc.identifier.endpage113tr_TR
dc.identifier.issn0263-6484
dc.identifier.issue2tr_TR
dc.identifier.pubmed21370246tr_TR
dc.identifier.scopus2-s2.0-79952217192tr_TR
dc.identifier.startpage108tr_TR
dc.identifier.urihttps://doi.org/10.1002/cbf.1729
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/21370246/
dc.identifier.urihttp://hdl.handle.net/11452/23804
dc.identifier.volume29tr_TR
dc.identifier.wos000288079400005tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectCell biologyen_US
dc.subjectUlva rigidaen_US
dc.subjectDiabetesen_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidant statusen_US
dc.subjectHyperlipidemiaen_US
dc.subjectSerum paraoxonase activityen_US
dc.subjectVanadyl sulfateen_US
dc.subjectMellitusen_US
dc.subjectAntioxidanten_US
dc.subjectExtracten_US
dc.subjectMiceen_US
dc.subjectAtherosclerosisen_US
dc.subjectAminoguanidineen_US
dc.subjectHyperglycemiaen_US
dc.subjectComplicationsen_US
dc.subjectChlorophytaen_US
dc.subjectRattusen_US
dc.subjectRattus norvegicusen_US
dc.subjectUlva rigidaen_US
dc.subject.emtreeAlgal extracten_US
dc.subject.emtreeAntidiabetic agenten_US
dc.subject.emtreeAryldialkylphosphataseen_US
dc.subject.emtreeArylesteraseen_US
dc.subject.emtreeDrinking wateren_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeInsulinen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeUlva rigida extracten_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAlgaen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeCarbohydrate metabolismen_US
dc.subject.emtreeCholesterol blood levelen_US
dc.subject.emtreeDiabetes mellitusen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeEnzyme activityen_US
dc.subject.emtreeErythrocyteen_US
dc.subject.emtreeGlucose blood levelen_US
dc.subject.emtreeHyperlipidemiaen_US
dc.subject.emtreeInsulin blood levelen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeStreptozocin diabetesen_US
dc.subject.emtreeTissue levelen_US
dc.subject.emtreeTriacylglycerol blood levelen_US
dc.subject.emtreeUlva rigidaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood glucoseen_US
dc.subject.meshCarbohydrate metabolismen_US
dc.subject.meshDiabetes mellitus, experimentalen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperlipidemiasen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshOxidative stressen_US
dc.subject.meshPlant preparationsen_US
dc.subject.meshRandom allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshUlvaen_US
dc.subject.scopusAryldialkylphosphatase; Arylesterase; Human PON1 Proteinen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell Biologyen_US
dc.titleUlva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic ratsen_US
dc.typeArticle
dc.wos.quartileQ3 (Biochemistry & molecular biology)en_US
dc.wos.quartileQ4 (Cell biology)en_US

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