Publication: Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats
dc.contributor.buuauthor | Taş, Sibel | |
dc.contributor.buuauthor | Çelikler, Serap | |
dc.contributor.buuauthor | Ziyanok, Sedef Ayvalık | |
dc.contributor.buuauthor | Sarandöl, Emre | |
dc.contributor.buuauthor | Dirican, Melahat | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Fen Edebiyat Fakültesi | |
dc.contributor.department | Biyokimya Ana Bilim Dalı | |
dc.contributor.department | Biyoloji Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0002-2593-7196 | |
dc.contributor.orcid | 0000-0002-4177-3478 | |
dc.contributor.orcid | 0000-0001-6225-774X | |
dc.contributor.researcherid | ABE-6873-2020 | |
dc.contributor.researcherid | ABE-1716-2020 | |
dc.contributor.researcherid | AAG-6985-2021 | |
dc.contributor.researcherid | AAH-2767-2021 | |
dc.contributor.scopusid | 7004343411 | |
dc.contributor.scopusid | 8234554800 | |
dc.contributor.scopusid | 15128398000 | |
dc.contributor.scopusid | 55943324800 | |
dc.contributor.scopusid | 6601919847 | |
dc.date.accessioned | 2022-01-03T06:55:29Z | |
dc.date.available | 2022-01-03T06:55:29Z | |
dc.date.issued | 2011-03 | |
dc.description.abstract | This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus. | |
dc.identifier.citation | Taş, S. vd. (2011). "Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats". Cell Biochemistry and Function, 29(2), 108-113. | |
dc.identifier.endpage | 113 | |
dc.identifier.issn | 0263-6484 | |
dc.identifier.issue | 2 | |
dc.identifier.pubmed | 21370246 | |
dc.identifier.scopus | 2-s2.0-79952217192 | |
dc.identifier.startpage | 108 | |
dc.identifier.uri | https://doi.org/10.1002/cbf.1729 | |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/21370246/ | |
dc.identifier.uri | http://hdl.handle.net/11452/23804 | |
dc.identifier.volume | 29 | |
dc.identifier.wos | 000288079400005 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.relation.journal | Cell Biochemistry and Function | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Biochemistry & molecular biology | |
dc.subject | Cell biology | |
dc.subject | Ulva rigida | |
dc.subject | Diabetes | |
dc.subject | Oxidative stress | |
dc.subject | Antioxidant status | |
dc.subject | Hyperlipidemia | |
dc.subject | Serum paraoxonase activity | |
dc.subject | Vanadyl sulfate | |
dc.subject | Mellitus | |
dc.subject | Antioxidant | |
dc.subject | Extract | |
dc.subject | Mice | |
dc.subject | Atherosclerosis | |
dc.subject | Aminoguanidine | |
dc.subject | Hyperglycemia | |
dc.subject | Complications | |
dc.subject | Chlorophyta | |
dc.subject | Rattus | |
dc.subject | Rattus norvegicus | |
dc.subject | Ulva rigida | |
dc.subject.emtree | Algal extract | |
dc.subject.emtree | Antidiabetic agent | |
dc.subject.emtree | Aryldialkylphosphatase | |
dc.subject.emtree | Arylesterase | |
dc.subject.emtree | Drinking water | |
dc.subject.emtree | Glutathione peroxidase | |
dc.subject.emtree | Insulin | |
dc.subject.emtree | Malonaldehyde | |
dc.subject.emtree | Superoxide dismutase | |
dc.subject.emtree | Ulva rigida extract | |
dc.subject.emtree | Unclassified drug | |
dc.subject.emtree | Alga | |
dc.subject.emtree | Animal experiment | |
dc.subject.emtree | Article | |
dc.subject.emtree | Blood | |
dc.subject.emtree | Carbohydrate metabolism | |
dc.subject.emtree | Cholesterol blood level | |
dc.subject.emtree | Diabetes mellitus | |
dc.subject.emtree | Drug effect | |
dc.subject.emtree | Enzyme activity | |
dc.subject.emtree | Erythrocyte | |
dc.subject.emtree | Glucose blood level | |
dc.subject.emtree | Hyperlipidemia | |
dc.subject.emtree | Insulin blood level | |
dc.subject.emtree | Male | |
dc.subject.emtree | Nonhuman | |
dc.subject.emtree | Oxidative stress | |
dc.subject.emtree | Priority journal | |
dc.subject.emtree | Rat | |
dc.subject.emtree | Streptozocin diabetes | |
dc.subject.emtree | Tissue level | |
dc.subject.emtree | Triacylglycerol blood level | |
dc.subject.emtree | Ulva rigida | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Blood glucose | |
dc.subject.mesh | Carbohydrate metabolism | |
dc.subject.mesh | Diabetes mellitus, experimental | |
dc.subject.mesh | Disease models, animal | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Hyperlipidemias | |
dc.subject.mesh | Male | |
dc.subject.mesh | Malondialdehyde | |
dc.subject.mesh | Oxidative stress | |
dc.subject.mesh | Plant preparations | |
dc.subject.mesh | Random allocation | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, wistar | |
dc.subject.mesh | Ulva | |
dc.subject.scopus | Aryldialkylphosphatase; Arylesterase; Human PON1 Protein | |
dc.subject.wos | Biochemistry & molecular biology | |
dc.subject.wos | Cell Biology | |
dc.title | Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats | |
dc.type | Article | |
dc.wos.quartile | Q3 (Biochemistry & molecular biology) | |
dc.wos.quartile | Q4 (Cell biology) | |
dspace.entity.type | Publication | |
local.contributor.department | Fen Edebiyat Fakültesi/Biyoloji Ana Bilim Dalı | |
local.contributor.department | Tıp Fakültesi/Biyokimya Ana Bilim Dalı | |
local.indexed.at | Scopus | |
local.indexed.at | WOS |
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