Publication:
Palladium(II) and platinum(II ) saccharinate complexes with bis(diphenylphosphino)methane/ ethane: synthesis, S-phase arrest and ROS- mediated apoptosis in human colon cancer cells

dc.contributor.authorAygün, Muhittin
dc.contributor.authorAlper, Pınar
dc.contributor.authorUlukaya, Engin
dc.contributor.buuauthorİcsel, Ceyda
dc.contributor.buuauthorYılmaz, Veysel Turan
dc.contributor.buuauthorCevatemre, Buse
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentKimya Bölümü
dc.contributor.orcid0000-0002-2717-2430tr_TR
dc.contributor.orcid0000-0002-2849-3332tr_TR
dc.contributor.researcheridAAI-3342-2021tr_TR
dc.contributor.researcheridL-7238-2018tr_TR
dc.contributor.researcheridAHD-2050-2022tr_TR
dc.contributor.scopusid55551960400tr_TR
dc.contributor.scopusid56441123900tr_TR
dc.contributor.scopusid55693788600tr_TR
dc.date.accessioned2024-03-25T09:04:06Z
dc.date.available2024-03-25T09:04:06Z
dc.date.issued2018-07-24
dc.description.abstractNew neutral [M(sac)(2)(diphos)] and cationic [M(diphos)(2)](sac)(2) complexes, where M = Pd-II or Pt-II, sac = saccharinate, and diphos = 1,1-bis(diphenylphosphino)methane (dppm) or 1,2-bis(diphenylphosphino)ethane (dppe), were synthesized and structurally characterized. The anticancer activity of the complexes was investigated against MCF-7 (breast), A549 (lung), HCT116 (colon), DU145 (prostate) cancer and BEAS-2B (normal bronchial epithelial) cells. Neutral Pt-dppm (2) and Pd-dppe complexes (5) did not show any biological activity. The cationic Pd-dppe (7) complex displayed antiproliferative activity, while the rest of the complexes exhibited potent cytotoxicity compared with cisplatin. The active Pd(ii)/Pt(ii) complexes were then included in further studies including interaction with DNA/HSA, nuclease activity, cellular uptake and lipophilicity. The potent complexes induced the apoptotic cell death as probed through annexin V positivity and caspase activation. Mechanistic studies on HCT116 cells showed that the complexes cause cell cycle arrest at the DNA synthesis (S) phase and excessive generation of reactive oxygen species (ROS), damaging to both mitochondria and DNA.en_US
dc.identifier.citationİcsel, C. vd. (2018). ''Palladium(II) and platinum(II ) saccharinate complexes with bis(diphenylphosphino)methane/ ethane: synthesis, S-phase arrest and ROS- mediated apoptosis in human colon cancer cells''. Dalton Transactions, 47(33), 11397-11410.en_US
dc.identifier.doihttps://doi.org/10.1039/c8dt02389aen_US
dc.identifier.eissn1477-9234
dc.identifier.endpage11410tr_TR
dc.identifier.issn1477-9226
dc.identifier.issue33tr_TR
dc.identifier.pubmed30062356tr_TR
dc.identifier.scopus2-s2.0-85052000363tr_TR
dc.identifier.startpage11397tr_TR
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2018/dt/c8dt02389aen_US
dc.identifier.urihttps://hdl.handle.net/11452/40609en_US
dc.identifier.volume47tr_TR
dc.identifier.wos000442509700014
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalDalton Transactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak215Z230
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdsorptive stripping voltammetryen_US
dc.subjectThiosaccharinate tsac complexesen_US
dc.subjectAscites-carcinoma eacen_US
dc.subjectDNA-binding agentsen_US
dc.subjectIn-vitroen_US
dc.subjectCrystal-structuresen_US
dc.subjectAntiproliferative activityen_US
dc.subjectMolecular-mechanismsen_US
dc.subjectAnticancer activityen_US
dc.subjectThermal-propertiesen_US
dc.subjectBioactivityen_US
dc.subjectCell deathen_US
dc.subjectCytotoxicityen_US
dc.subjectDiseasesen_US
dc.subjectDNAen_US
dc.subjectMethaneen_US
dc.subjectPlatinum compoundsen_US
dc.subjectSynthesis (chemical)en_US
dc.subjectAnti-proliferative activitiesen_US
dc.subjectAnticancer activitiesen_US
dc.subjectApoptotic cell deathen_US
dc.subjectCaspase activationen_US
dc.subjectHuman colon cancer cellsen_US
dc.subjectInteraction with dnasen_US
dc.subjectMechanistic studiesen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectPalladium compoundsen_US
dc.subjectChemistryen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeDNAen_US
dc.subject.emtreeEthaneen_US
dc.subject.emtreeHuman serum albuminen_US
dc.subject.emtreeMethaneen_US
dc.subject.emtreePalladiumen_US
dc.subject.emtreePlatinumen_US
dc.subject.emtreePlatinum complexen_US
dc.subject.emtreeReactive oxygen metaboliteen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeChemical phenomenaen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeColon tumoren_US
dc.subject.emtreeConformationen_US
dc.subject.emtreeDouble stranded DNA breaken_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeHCT 116 cell lineen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMitochondrial membrane potentialen_US
dc.subject.emtreeMolecular dockingen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreeProtein conformationen_US
dc.subject.emtreeS phase cell cycle checkpointen_US
dc.subject.emtreeSynthesisen_US
dc.subject.emtreeTransport at the cellular levelen_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshBiological transporten_US
dc.subject.meshChemistry techniques, syntheticen_US
dc.subject.meshColonic neoplasmsen_US
dc.subject.meshDNAen_US
dc.subject.meshDNA breaks, double-strandeden_US
dc.subject.meshEthaneen_US
dc.subject.meshHCT116 cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrophobic and hydrophilic interactionsen_US
dc.subject.meshMembrane potential, mitochondrialen_US
dc.subject.meshMethaneen_US
dc.subject.meshMolecular docking simulationen_US
dc.subject.meshNucleic acid conformationen_US
dc.subject.meshOrganoplatinum compoundsen_US
dc.subject.meshPalladiumen_US
dc.subject.meshPlatinumen_US
dc.subject.meshProtein conformationen_US
dc.subject.meshReactive oxygen speciesen_US
dc.subject.meshS phase cell cycle checkpointsen_US
dc.subject.meshSerum albumin, humanen_US
dc.subject.scopusComplex; Palladium; 2-Phenylpyridineen_US
dc.subject.wosChemistry, inorganic & nuclearen_US
dc.titlePalladium(II) and platinum(II ) saccharinate complexes with bis(diphenylphosphino)methane/ ethane: synthesis, S-phase arrest and ROS- mediated apoptosis in human colon cancer cellsen_US
dc.typeArticleen_US
dc.wos.quartileQ1 (Chemistry, inorganic & nuclear)en_US
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Kimya Bölümütr_TR
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümütr_TR

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