Molecular identification of HIV-1 in the presence of hepatitis B virus and hepatitis C virus Co-infections

dc.contributor.authorSayan, Murat
dc.contributor.authorÖzgüler, Müge
dc.contributor.authorYıldırım, Figen
dc.contributor.authorYıldırmak, Taner
dc.contributor.authorGündüz, Alper
dc.contributor.authorDokuzoğuz, Başak
dc.contributor.authorÇelen, Mustafa Kemal
dc.contributor.authorİnan, Dilara
dc.contributor.authorErsöz, Gülden
dc.contributor.authorKaraoğlan, İlkay
dc.contributor.authorCeran, Nurgül
dc.contributor.buuauthorHeper, Yasemin
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-6635-5416tr_TR
dc.contributor.researcheridAAH-6506-2021tr_TR
dc.contributor.scopusid56191003300tr_TR
dc.date.accessioned2022-12-22T05:33:16Z
dc.date.available2022-12-22T05:33:16Z
dc.date.issued2020-02-24
dc.descriptionBu çalışma, 14-17 Eylül 2016 tarihleri arasında Lizbon[Portekiz]'de düzenlenen 19. Meeting of the European Society for Clinical Virology'de bildiri olarak sunulmuştur.tr_TR
dc.description.abstractBackground: Because of their similar modes of transmission, the simultaneous infection of viral hepatitis and human immunodeficiency virus are increasingly seen as a big problem related to human health. Aims: To determine the drug mutations in hepatitis B virus and/or hepatitis C virus co-infected human immunodeficiency virus-1 patients in Turkey. Study Design: Retrospective cross-sectional study. Methods: The present study was conducted between 2010 and 2017. HBsAg, anti-hepatitis C virus, and anti-human immunodeficiency vim were tested with ELISA. All anti-human immunodeficiency virus positive results by ELISA were verified for anti-human immunodeficiency virus positivity by a Western blot test, and Antihuman immunodeficiency virus positive patients with HBsAg andior anti-hepatitis C virus positivity were included in the study. Subtyping and genotypic resistance analyses were performed by population sequencing of the viral protease and reverse transcriptase regions of the human immunodeficiency virus-1 pol gene. Results: We detected 3896 human immunodeficiency virus-1 positive patients whose sera were sent from numerous hospitals across the country to our polymerase chain reaction unit for detection of drug resistance mutations and whose molecular laboratory tests were completed. Viral hepatitis co-infections were detected in 4.3% (n=170) of patients. Hepatitis B virus and hepatitis C virus co-infection were observed in 3.2% and 0.5% of all human immunodeficiency virus-I infected patients, respectively. The major human immunodeficiency virus-1 subtype detected was group M, subtype B (62.9%). However, 13.5% of drug resistance mutation motifs were found in human immunodeficiency virus-1 genomes of patients included in the study. Conclusion: Due to similar transmission routes, HIV1 patients are at risk of hepatitis B and C virus co-infection. However, antiretroviral drug resistance mutation model is similar to patients with hepatitis negative.en_US
dc.description.sponsorshipEuropean Society for Clinical Virologyen_US
dc.identifier.citationSayan, M. vd. (2020). "Molecular identification of HIV-1 in the presence of hepatitis B virus and hepatitis C virus Co-infections". Balkan Medical Journal, 37(3), 125-130.tr_TR
dc.identifier.endpage130tr_TR
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue3tr_TR
dc.identifier.pubmed32106666tr_TR
dc.identifier.scopus2-s2.0-85083621463tr_TR
dc.identifier.startpage125tr_TR
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2020.2019.5.89
dc.identifier.urihttps://www.balkanmedicaljournal.org/uploads/pdf/pdf_BMJ_2188.pdf
dc.identifier.urihttp://hdl.handle.net/11452/30023
dc.identifier.volume37tr_TR
dc.identifier.wos000526082100003tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.indexed.wosCPCISen_US
dc.language.isoenen_US
dc.publisherGalenos Yayıncılıktr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCo-infectionen_US
dc.subjectHepatitis B virusen_US
dc.subjectHepatitis C virusen_US
dc.subjectHIV-1en_US
dc.subjectMolecular epidemiologyen_US
dc.subjectInfectionsen_US
dc.subjectAdultsen_US
dc.subjectImpacten_US
dc.subjectGeneral & internal medicineen_US
dc.subject.emtreeHepatitis B surface antigenen_US
dc.subject.emtreeNonnucleoside reverse transcriptase inhibitoren_US
dc.subject.emtreeProteinaseen_US
dc.subject.emtreeProteinase inhibitoren_US
dc.subject.emtreeRNA directed DNA polymeraseen_US
dc.subject.emtreeRNA directed DNA polymerase inhibitoren_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCross-sectional studyen_US
dc.subject.emtreeDisease transmissionen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGene mutationen_US
dc.subject.emtreeGene sequenceen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHepatitis Ben_US
dc.subject.emtreeHepatitis Cen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman immunodeficiency virus infectionen_US
dc.subject.emtreeInfection risken_US
dc.subject.emtreeLaboratory testen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMixed infectionen_US
dc.subject.emtreeMolecular epidemiologyen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreePrevalenceen_US
dc.subject.emtreeEtrospective studyen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeVirus detectionen_US
dc.subject.emtreeVirus geneen_US
dc.subject.emtreeVirus resistanceen_US
dc.subject.emtreeWestern blottingen_US
dc.subject.emtreeHepacivirusen_US
dc.subject.emtreeHepatitis Ben_US
dc.subject.emtreeHepatitis B virusen_US
dc.subject.emtreeHepatitis Cen_US
dc.subject.emtreeHuman immunodeficiency virus infectionen_US
dc.subject.emtreeMixed infectionen_US
dc.subject.emtreePathogenicityen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreeProceduresen_US
dc.subject.emtreeTurkey (bird)en_US
dc.subject.emtreeVirologyen_US
dc.subject.meshCoinfectionen_US
dc.subject.meshCross-sectional studiesen_US
dc.subject.meshHepacivirusen_US
dc.subject.meshHepatitis Ben_US
dc.subject.meshHepatitis B virusen_US
dc.subject.meshHepatitis Cen_US
dc.subject.meshHIV infectionsen_US
dc.subject.meshHumansen_US
dc.subject.meshPolymerase chain reactionen_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusViral Load; Dried Blood Spot Testing; Human Immunodeficiency Virus 1en_US
dc.subject.wosMedicine, general & internalen_US
dc.titleMolecular identification of HIV-1 in the presence of hepatitis B virus and hepatitis C virus Co-infectionsen_US
dc.typeArticle
dc.typeProceedings Paper
dc.wos.quartileQ3en_US

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