Varenicline disrupts prepulse inhibition only in high-inhibitory rats

dc.contributor.authorGöktalay, Tuğba
dc.contributor.authorCoşkun, Ayşın Şakar
dc.contributor.authorYorgancıoğlu, Arzu A.
dc.contributor.authorKayır, Hakan
dc.contributor.authorUzbay, Tayfun
dc.contributor.buuauthorBuyükuysal, Sema
dc.contributor.buuauthorUslu, Gülşah
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-1448-2021tr_TR
dc.contributor.scopusid57194751676tr_TR
dc.contributor.scopusid56084705600tr_TR
dc.contributor.scopusid6508023759tr_TR
dc.date.accessioned2024-02-15T06:19:07Z
dc.date.available2024-02-15T06:19:07Z
dc.date.issued2014-03-04
dc.description.abstractVarenicline, a widely used smoking cessation drug, has partial agonistic activity at alpha 4 beta 2 nicotinic receptors, and full agonistic activity at alpha 7 nicotinic receptors. Thus it may interact with cognitive processes and may alleviate some of the cognitive disturbances observed in psychotic illnesses such as schizophrenia. We aimed to test the effects of varenicline on sensorimotor gating functioning, which is crucial for normal cognitive processes, especially for the integration of sensory and cognitive information processing and the execution of appropriate motor responses. Prepulse inhibition (PPI) of the acoustic startle reflex was used to test the sensorimotor gating functioning. First, the effects of varenicline and nicotine on rats having high or low baseline PPI levels were evaluated; then, varenicline was applied prior to apomorphine (0.5 mg/kg), and MK-801 (0.15 mg/kg), which are used as comparative models of PPI disruption. Varenicline (0.5-3 mg/kg) did not change PPI when given alone in naive animals. When rats were selected according to their baseline PPI values, varenicline (1 mg/kg) significantly decreased PPI in high-inhibitory (HI) but not in low inhibitory (LI) rats. Nicotine (1 mg/kg; tartrate salt) produced a similar activity in LI and HI groups. In combination experiments, varenicline did not reverse either apomorphine or the MK-801-induced disruption of PPI. These results demonstrate that the effects of both varenicline and nicotine on sensorimotor gating are influenced by the baseline PPI levels. Moreover, varenicline has no effect on apomorphine or the MK-801-induced disruption of PPI. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationGöktalay, T. vd. (2014). "Varenicline disrupts prepulse inhibition only in high-inhibitory rats". Progress in Neuro-Psychopharmacology and Biological Psychiatry, 53, 54-60.en_US
dc.identifier.doihttps://doi.org/10.1016/j.pnpbp.2014.03.001en_US
dc.identifier.endpage60tr_TR
dc.identifier.issn0278-5846
dc.identifier.pubmed24632394tr_TR
dc.identifier.scopus2-s2.0-84896944199tr_TR
dc.identifier.startpage54tr_TR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0278584614000451en_US
dc.identifier.urihttps://hdl.handle.net/11452/39727en_US
dc.identifier.volume53tr_TR
dc.identifier.wos000338813600007tr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.bapT-2008/4
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNicotineen_US
dc.subjectVareniclineen_US
dc.subjectPrepulse inhibition (PPI)en_US
dc.subjectSchizophreniaen_US
dc.subjectRat(s)en_US
dc.subjectNicotinic acetylcholine-receptorsen_US
dc.subjectHigh p50 suppressorsen_US
dc.subjectPsychiatryen_US
dc.subjectDouble-blind placeboen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectSchizoaffective disorderen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectBase-lineen_US
dc.subjectSmokingen_US
dc.subjectPartial agonisten_US
dc.subjectSchizophreniaen_US
dc.subjectHealthy humansen_US
dc.subjectC57bl/6 miceen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug dose comparisonen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMorning dosageen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePrepulse inhibitionen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSensory gatingen_US
dc.subject.emtreeStartle reflexen_US
dc.subject.emtreeAcousticsen_US
dc.subject.emtreeAnalysis of varianceen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeAuditory stimulationen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreePrepulse inhibitionen_US
dc.subject.emtreeSprague dawley raten_US
dc.subject.emtreeApomorphineen_US
dc.subject.emtreeDizocilpineen_US
dc.subject.emtreeNicotineen_US
dc.subject.emtreeVareniclineen_US
dc.subject.emtreeAmino acid receptor blocking agenten_US
dc.subject.emtreeApomorphineen_US
dc.subject.emtreeBenzazepine derivativeen_US
dc.subject.emtreeDizocilpine maleateen_US
dc.subject.emtreeDopamine receptor stimulating agenten_US
dc.subject.emtreeNicotineen_US
dc.subject.emtreeNicotinic agenten_US
dc.subject.emtreeQuinoxaline derivativeen_US
dc.subject.emtreeVareniclineen_US
dc.subject.meshAcoustic stimulationen_US
dc.subject.meshAcousticsen_US
dc.subject.meshAnalysis of varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApomorphineen_US
dc.subject.meshBenzazepinesen_US
dc.subject.meshDizocilpine maleateen_US
dc.subject.meshDopamine agonistsen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshExcitatory amino acid antagonistsen_US
dc.subject.meshMaleen_US
dc.subject.meshNicotineen_US
dc.subject.meshNicotinic agonistsen_US
dc.subject.meshPrepulse inhibitionen_US
dc.subject.meshQuinoxalinesen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshReflex, startleen_US
dc.subject.scopusPrepulse Inhibition; Startle Reflex; Sensory Gatingen_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosPsychiatryen_US
dc.subject.wosNeurosciencesen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleVarenicline disrupts prepulse inhibition only in high-inhibitory ratsen_US
dc.typeArticleen_US
dc.wos.quartileQ1 ( Clinical Neurology)en_US
dc.wos.quartileQ2en_US

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