Impaired aortic distensibility in hypothyroid patients with negative coronary angiograms: Simultaneous evaluation with 128-slice multiple row detector computed tomography

dc.contributor.buuauthorDuşak, Abdürrahim
dc.contributor.buuauthorGökalp, Gökhan
dc.contributor.buuauthorErdoǧan, Cüneyt
dc.contributor.buuauthorParlak, Müfit
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-8521-2021tr_TR
dc.contributor.researcheridA-7826-2019tr_TR
dc.contributor.researcheridAAI-2336-2021tr_TR
dc.contributor.scopusid6507393726tr_TR
dc.contributor.scopusid8312505100tr_TR
dc.contributor.scopusid8293835700tr_TR
dc.contributor.scopusid7003589220tr_TR
dc.date.accessioned2022-12-30T12:46:52Z
dc.date.available2022-12-30T12:46:52Z
dc.date.issued2013-03-01
dc.description.abstractObjective To determine the relationship between arterial distensibility and hypothyroidism by simultaneous assessment of coronary angiography and aortic distensibility, measured using 128-slice retrospective electrocardiogram-gated multiple row detector computed tomography (MDCT). Methods Untreated hypothyroid patients and age-matched euthyroid patients, who underwent 128-slice retrospective electrocardiogram-gated MDCT to evaluate the coronary arteries, were assessed. Intraluminal aortic areas in systolic and diastolic phases of the cardiac cycle were measured with multiphase reformation at predefined locations including the ascending aorta, proximal descending aorta and distal descending aorta in the widest axial plane. Results The study included 21 hypothyroid and 21 euthyroid patients. Patients with hypothyroidism exhibited decreased aortic distensibility between each location in the thoracic aorta (ascending aorta, proximal descending aorta and distal descending aorta) compared with euthryoid patients. Conclusions Hypothyroidism was associated with preclinical vascular alteration, characterized by impaired aortic distensibility at each location of the thoracic aorta, which has been shown to be related to increased cardiovascular risk. Monitoring of aortic distensibility is relevant for evaluating coronary artery disease progression and treatment choices.en_US
dc.identifier.citationDuşak, A. vd. (2013). “Impaired aortic distensibility in hypothyroid patients with negative coronary angiograms: Simultaneous evaluation with 128-slice multiple row detector computed tomography”. Journal of International Medical Research, 41(5), 1691-1698.en_US
dc.identifier.endpage1698tr_TR
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue5tr_TR
dc.identifier.pubmed24026774tr_TR
dc.identifier.scopus2-s2.0-84887286294tr_TR
dc.identifier.startpage1691tr_TR
dc.identifier.urihttps://doi.org/10.1177/0300060513489479
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/0300060513489479
dc.identifier.urihttp://hdl.handle.net/11452/30201
dc.identifier.volume41tr_TR
dc.identifier.wos000325273700032tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.journalJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectAortic distensibilityen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectHypothyroidismen_US
dc.subjectMultiple row detector computed tomographyen_US
dc.subjectMDCTen_US
dc.subjectFlow velocity reserveen_US
dc.subjectCommon carotid-arteryen_US
dc.subjectFatty liver-disaseen_US
dc.subjectPulse-wave velocityen_US
dc.subjectSubclinical hypothyroidismen_US
dc.subjectThyroxine treatmenten_US
dc.subjectYoung-adultsen_US
dc.subjectStiffnessen_US
dc.subjectAtherosclerosisen_US
dc.subjectRisken_US
dc.subjectAortic distensibilityen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectHypothyroidismen_US
dc.subjectMultiple row detector computed tomographyen_US
dc.subject.emtreeLiothyronineen_US
dc.subject.emtreeLow density lipoproteinen_US
dc.subject.emtreeThyrotropinen_US
dc.subject.emtreeThyroxineen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAngiocardiographyen_US
dc.subject.emtreeArtery complianceen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAscending aortaen_US
dc.subject.emtreeAtherosclerosisen_US
dc.subject.emtreeCardiac gated imagingen_US
dc.subject.emtreeCardiovascular risken_US
dc.subject.emtreeCholesterol blood levelen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeComputed tomography scanneren_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCoronary artery diseaseen_US
dc.subject.emtreeDescending aortaen_US
dc.subject.emtreeElectrocardiogram gated multiple row detector computed tomographyen_US
dc.subject.emtreeElectrocardiographyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHypothyroidismen_US
dc.subject.emtreeMultidetector computed tomographyen_US
dc.subject.emtreeThoracic aortaen_US
dc.subject.meshAortaen_US
dc.subject.meshAorta, thoracicen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshCoronary angiographyen_US
dc.subject.meshDisease progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidismen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshTomography, x-ray computeden_US
dc.subject.meshVascular stiffnessen_US
dc.subject.scopusHypothyroidism; Thyrotropin; Thyroid Functionen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleImpaired aortic distensibility in hypothyroid patients with negative coronary angiograms: Simultaneous evaluation with 128-slice multiple row detector computed tomographyen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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