A study on molecular characterization of macrolide resistance mechanism among isolates of Streptococcus pneumoniae from the southern Marmara region of Turkey, as well as resistance to macrolides and penicillin in these isolates

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dc.contributor.authorGüler, Hicran
dc.contributor.authorGürcüoğlu, Emel
dc.contributor.authorÖzbey, Saliha Bakır
dc.contributor.buuauthorÖzakın, Cüneyt
dc.contributor.buuauthorKazak, Esra
dc.contributor.buuauthorSınırtaş, Ayşe Melda
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-5428-3630tr_TR
dc.contributor.researcheridAAG-8459-2021tr_TR
dc.contributor.researcheridAAG-8392-2021tr_TR
dc.contributor.scopusid57200678942tr_TR
dc.contributor.scopusid24921238200tr_TR
dc.contributor.scopusid54788212600tr_TR
dc.date.accessioned2022-04-14T12:33:27Z
dc.date.available2022-04-14T12:33:27Z
dc.date.issued2012-02
dc.description.abstractAim: To determine the distribution of macrolide resistance genes as well as resistance rates in isolated Streptococcus pneumoniae strains from the southern Marmara region of Turkey. Materials and methods: Antimicrobial resistance rates and MIC values were determined by the E-test method in 300 Streptococcus pneumoniae isolates that were isolated from clinical samples. Resistance genes were determined by the polymerase chain reaction (PCR) method in erythromycin-resistant strains. Results: It was found that 11.4% of Streptococcus pneumoniae isolates were resistant to macrolides. The penicillin MIC value was >= 0.12 mu g/mL in 23% of the strains and 2 mu g/mL in 2% of the strains. The erm(B) genotype was observed in 58.8% of all macrolide-resistant strains, 38.2% were of the mef(A) genotype, and 3% were a combination of both genotypes. Conclusion: Based on the data from this study, it was concluded that the local resistance to antibiotics is not as high as that observed in other countries, and the erm(B) genotype was dominant in macrolide-resistant strains. Therefore, it is suggested that macrolide-group antibiotics still be included in treatment protocols.en_US
dc.description.abstractSon yıllarda Streptococcus pneumoniae suşlarında makrolid ve diğer antibiyotiklere giderek artan bir direnç oranı mevcuttur. Bu çalışmada Türkiye’de Güney Marmara Bölgesi’nden izole edilen S. pneumoniae suşlarında penisilin ve makrolidler için minimum inhibitör konsantrasyonlarının ve makrolid direnç mekanizmasının genetik dağılımının tespit edilmesi amaçlanmıştır. Yöntem ve gereç: Çalışmada klinik örneklerden izole edilen 300 adet S. pneumoniae izolatında E test yöntemi ile antimikrobiyal direnç oranları ve MIK değerleri ve eritromisine dirençli izolatlarda ise PCR yöntemiyle direnç genleri tespit edildi. Çalışmada makrolid direnci % 11,4 oranında bulundu. Penisilin MIC değeri 0,12 μg/mL ve üzeri olan suşlar % 23 oranında, penisilin MIC değeri 2 μg/mL olan suşlar % 2 oranında bulundu. Makrolid dirençli izolatların % 58,8’inde erm(B) genotipi, % 38,2’sinde mef(A) genotipi, ve % 3’ünde her iki direnç genotipi birden tespit edildi. Sonuç: Bölgemizde izole edilen suşlarda antibiyotik direncinin yüksek olmadığı ve makrolid direnci olan suşlarda erm(B) tipi direnç geninin hakim olduğu görüldü. Bölgemizde direnç oranlarının yüksek olmaması nedeniyle tedavi protokolünde makrolid grubu antibiyotikler kullanılabilir.tr_TR
dc.identifier.citationÖzakın, C. vd. (2012). "A study on molecular characterization of macrolide resistance mechanism among isolates of Streptococcus pneumoniae from the southern Marmara region of Turkey, as well as resistance to macrolides and penicillin in these isolates". Turkish Journal of Medical Sciences, 42(1), 137-144.tr_TR
dc.identifier.endpage144tr_TR
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1tr_TR
dc.identifier.scopus2-s2.0-84055188673tr_TR
dc.identifier.startpage137tr_TR
dc.identifier.urihttps://doi.org/10.3906/sag-1007-975
dc.identifier.urihttps://journals.tubitak.gov.tr/medical/abstract.htm?id=12412
dc.identifier.urihttp://hdl.handle.net/11452/25790
dc.identifier.volume42tr_TR
dc.identifier.wos000300203500018tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTÜBİTAKen_US
dc.relation.bapT 2006/50tr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectMef(a)en_US
dc.subjectErm(b)en_US
dc.subjectPcren_US
dc.subjectS. pneumoniaeen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectBacterial-resistanceen_US
dc.subjectPyogenesen_US
dc.subjectSusceptibilityen_US
dc.subjectPrevalenceen_US
dc.subjectPathogensen_US
dc.subject.emtreeAzithromycinen_US
dc.subject.emtreeClarithromycinen_US
dc.subject.emtreeErythromycinen_US
dc.subject.emtreeMacrolideen_US
dc.subject.emtreePenicillin gen_US
dc.subject.emtreeAntibiotic resistanceen_US
dc.subject.emtreeAntibiotic sensitivityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBacterial geneen_US
dc.subject.emtreeBacterial strainen_US
dc.subject.emtreeBacterium cultureen_US
dc.subject.emtreeBacterium isolateen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEpsilometer testen_US
dc.subject.emtreeermB geneen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreemefA geneen_US
dc.subject.emtreeMinimum inhibitory concentrationen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreeStreptococcus pneumoniaeen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.scopusMacrolides; Streptococcus Group A; Erythromycinen_US
dc.subject.wosMedicine, general & internalen_US
dc.titleA study on molecular characterization of macrolide resistance mechanism among isolates of Streptococcus pneumoniae from the southern Marmara region of Turkey, as well as resistance to macrolides and penicillin in these isolatesen_US
dc.title.alternativeTürkiye'nin Güney Marmara Bölgesi'nden izole edilen Streptococcus pneumoniae suşlarında makrolid ve penisilin direnci ve makrolid direncinin moleküler özelliǧitr_TR
dc.typeArticle
dc.wos.quartileQ4en_US

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