Do liver IL-12 levels predict sustained response to ifn-α therapy in children with chronic hepatitis B?

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dc.contributor.buuauthorÖzkan, Tanju B.
dc.contributor.buuauthorBudak, Ferah
dc.contributor.buuauthorErdemir, Gülin
dc.contributor.buuauthorÖzgür, Taner
dc.contributor.buuauthorAker, Sibel
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/ Tıbbi Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/ Tıbbi Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-5740-9729tr_TR
dc.contributor.researcheridAAG-8381-2021tr_TR
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.scopusid7004474005tr_TR
dc.contributor.scopusid6701913697tr_TR
dc.contributor.scopusid36015044400tr_TR
dc.contributor.scopusid36087775800tr_TR
dc.contributor.scopusid12795285000tr_TR
dc.date.accessioned2022-01-25T08:20:04Z
dc.date.available2022-01-25T08:20:04Z
dc.date.issued2010-06
dc.description.abstractThe aim of this study is to investigate the immunoregulatory role of interleukin-12 and interferon-gamma in children with chronic hepatitis B who are treated with interferon-alpha therapy. The patients were divided into 2 groups: Group I included 16 children with naive chronic replicative hepatitis B infection, and Group II included 6 children who are inactive hepatitis B virus (HBV) carriers. Group I received interferon-alpha subcutaneously (10 mU/m(2)/dose), 3 times a week during 4 months. Initial serum alanine aminotransferase (ALT) levels, hepatitis B serologic markers, serum interleukin-12 and interferon-gamma levels were measured. In Group I, laboratory tests were re-evaluated in the second and fourth months. Liver biopsy was performed in all patients and samples were used for tissue interleukin-12 level evaluation and histopathological examination. Hepatic activity index (HAI) and serum interferon-gamma were significantly higher in Group I (P < 0.05). Initial tissue interleukin-12 levels in Group I were low but a significant increase was observed at the fourth month (P < 0.05). While responder patients in Group I had marked elevation of tissue interleukin-12 levels, nonresponders did not reveal considerable changes at the fourth month evaluation. A negative correlation was found between serum HBV-DNA copies and interferon-gamma levels prior to therapy (P < 0.01, r: -0.66). The analysis of cytokine levels with serum transaminases demonstrated a positive correlation between the tissue interleukin-12 levels at the fourth month and serum ALT levels at the beginning and second month of the therapy (r: 0.77, P < 0.05 and r: 0.92, P < 0.05, respectively). This is the first study emphasizing the relationship between tissue cytokine levels and therapy success. Understanding the course of chronic hepatits B in the pediatric population will help us to clarify some debates on the treatment.en_US
dc.identifier.citationÖzkan, T. B. vd. (2010). "Do liver IL-12 levels predict sustained response to ifn-α therapy in children with chronic hepatitis B?". Journal of Interferon and Cytokine Research, 30(6), 433-438.en_US
dc.identifier.endpage438tr_TR
dc.identifier.issn1079-9907
dc.identifier.issn1557-7465
dc.identifier.issue6tr_TR
dc.identifier.pubmed20307202tr_TR
dc.identifier.scopus2-s2.0-77953585611tr_TR
dc.identifier.startpage433tr_TR
dc.identifier.urihttps://doi.org/10.1089/jir.2008.0102
dc.identifier.urihttps://www.liebertpub.com/doi/10.1089/jir.2008.0102
dc.identifier.urihttp://hdl.handle.net/11452/24282
dc.identifier.volume30tr_TR
dc.identifier.wos000278667400008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherMary Ann Lieberten_US
dc.relation.journalJournal of Interferon and Cytokine Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectT-cell proliferationen_US
dc.subjectInterferon-alphaen_US
dc.subjectVirus-infectionen_US
dc.subjectCytokine profilesen_US
dc.subjectLymphocytesen_US
dc.subjectGenerationen_US
dc.subjectClearanceen_US
dc.subjectInductionen_US
dc.subjectTH1en_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectCell biologyen_US
dc.subjectImmunologyen_US
dc.subjectHepatitis B virusen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeGamma interferonen_US
dc.subject.emtreeGamma interferon antibodyen_US
dc.subject.emtreeInterleukin 12en_US
dc.subject.emtreePeginterferon alphaen_US
dc.subject.emtreeRecombinant alpha2b interferonen_US
dc.subject.emtreeVirus DNAen_US
dc.subject.emtreeAlanine aminotransferase blood levelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCopy number variationen_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHepatitis Ben_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLaboratory testen_US
dc.subject.emtreeLiver biopsyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePreschool childen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeSchool childen_US
dc.subject.emtreeTreatment responseen_US
dc.subject.emtreeVirus replicationen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshDNA, viralen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B virusen_US
dc.subject.meshHepatitis B, chronicen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunotherapyen_US
dc.subject.meshInjections, subcutaneousen_US
dc.subject.meshInterferon-alphaen_US
dc.subject.meshInterferon-gammaen_US
dc.subject.meshInterleukin-12en_US
dc.subject.meshLiveren_US
dc.subject.meshMaleen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.meshVirus replicationen_US
dc.subject.scopusChronic Hepatitis B; HBV; Marmotaen_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.subject.wosImmunologyen_US
dc.titleDo liver IL-12 levels predict sustained response to ifn-α therapy in children with chronic hepatitis B?en_US
dc.typeArticle
dc.wos.quartileQ3en_US
dc.wos.quartileQ2 (Immunology)en_US

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