Effect of intravenously injected arachidonic acid on electrocardiography in rats

Abstract

Arachidonic acid (AA), which is released from phospholipids in the cell membrane by a variety of stimuli, has physiological and pathophysiological roles in the cardiovascular system. The current study was designed to determine the effect of intravenously (iv) injected AA on the electrocardiography (ECG) of the anesthetized rats. The ECG waves obtained from the lead II were written by placing electrodes on limbs of the ketamine and xylazine mixture (50 mg/kg/20 mg/ kg; im) in anesthetized adult Spraque Dawley rats. AA (3 mg/kg; iv) statistically significantly (p<0.05) caused to prolong of the ECG waves and intervals, resulting in a decrease in the heart rate of the rats. The current findings herein present the effect of the most abundant endogenous unsaturated fatty acid AA on ECG. The results clearly showed that AA could produce to bradycardia response by increasing the ECG waves and interval durations.