Cytotoxic activity of novel palladium-based compounds on leukemia cell lines
dc.contributor.author | Antunovic, Maja | |
dc.contributor.author | Kriznik, Bojana | |
dc.contributor.author | Mihalic, Katarina C. | |
dc.contributor.author | Madunic, Josip | |
dc.contributor.author | Marijanovic, Inga | |
dc.contributor.buuauthor | Ulukaya, Engin | |
dc.contributor.buuauthor | Yılmaz, Veysel T. | |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-2849-3332 | tr_TR |
dc.contributor.researcherid | L-7238-2018 | tr_TR |
dc.contributor.researcherid | K-5792-2018 | tr_TR |
dc.contributor.scopusid | 56441123900 | tr_TR |
dc.contributor.scopusid | 6602927353 | tr_TR |
dc.date.accessioned | 2022-08-11T13:01:36Z | |
dc.date.available | 2022-08-11T13:01:36Z | |
dc.date.issued | 2015-02 | |
dc.description.abstract | Effective treatment methods for human leukemia are under development, but so far none of them have been found to be completely satisfactory. It was recently reported that palladium complexes have significant anticancer activity as well as lower toxicity compared with some clinically used chemotherapeutics. The anticancer activities of two novel palladium(II) complexes, [Pd(sac)(terpy)](sac)center dot 4H(2)O and [PdCl(terpy)](sac)center dot 2H(2)O, were tested against three human leukemia cell lines, Jurkat, MOLT-4, and THP-1, in comparison with cisplatin and adriamycin. The cytotoxic effect of the drugs was determined using the MTT assay. Cell death was assessed using fluorescein isothiocyanate-annexin/propidium iodide staining for flow cytometry. Furthermore, p53 phosphorylation, poly(ADP-ribose) polymerase cleavage, and Bax and Bcl-2 mRNA levels were examined to elucidate the mechanism of cell death induction. Both complexes exhibited a significant dose-dependent antigrowth effect in vitro. The complexes predominately induced apoptosis, but necrosis was also observed. In-vitro results have shown that palladium(II) complexes may be regarded as potential anticancer agents for treating human leukemia. Therefore, further analysis to determine the putative mechanism of action and in-vivo studies on animal models are warranted. | en_US |
dc.identifier.citation | Antunovic, M. vd. (2015). "Cytotoxic activity of novel palladium-based compounds on leukemia cell lines". Anticancer Drugs, 26(2), 180-186. | tr_TR |
dc.identifier.endpage | 186 | tr_TR |
dc.identifier.issn | 0959-4973 | |
dc.identifier.issn | 1473-5741 | |
dc.identifier.issue | 2 | tr_TR |
dc.identifier.pubmed | 25280061 | tr_TR |
dc.identifier.scopus | 2-s2.0-84940492965 | tr_TR |
dc.identifier.startpage | 180 | tr_TR |
dc.identifier.uri | https://doi.org/10.1097/CAD.0000000000000174 | |
dc.identifier.uri | https://journals.lww.com/anti-cancerdrugs/Fulltext/2015/02000/Cytotoxic_activity_of_novel_palladium_based.6.aspx | |
dc.identifier.uri | http://hdl.handle.net/11452/28175 | |
dc.identifier.volume | 26 | tr_TR |
dc.identifier.wos | 000346763800006 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Anti-cancer Drugs | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Leukemia | en_US |
dc.subject | Palladium(II) complexes | en_US |
dc.subject | Poly(ADP-ribose) polymerase | en_US |
dc.subject | In-vitro | en_US |
dc.subject | Saccharinate complexes | en_US |
dc.subject | Breast-cancer | en_US |
dc.subject | Platinum(II) | en_US |
dc.subject | Death agents | en_US |
dc.subject | Oncology | en_US |
dc.subject | Pharmacology & pharmacy | en_US |
dc.subject.emtree | Antineoplastic agent | en_US |
dc.subject.emtree | Cisplatin | en_US |
dc.subject.emtree | Coordination compound | en_US |
dc.subject.emtree | Doxorubicin | en_US |
dc.subject.emtree | Palladium | en_US |
dc.subject.emtree | Apoptosis | en_US |
dc.subject.emtree | Cell death | en_US |
dc.subject.emtree | Chemistry | en_US |
dc.subject.emtree | Dose response | en_US |
dc.subject.emtree | Drug effects | en_US |
dc.subject.emtree | Drug screening | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Jurkat cell line | en_US |
dc.subject.emtree | Leukemia | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Physiology | en_US |
dc.subject.emtree | Procedures | en_US |
dc.subject.emtree | Tumor cell line | en_US |
dc.subject.mesh | Antineoplastic agents | en_US |
dc.subject.mesh | Apoptosis | en_US |
dc.subject.mesh | Cell death | en_US |
dc.subject.mesh | Cell line, tumor | en_US |
dc.subject.mesh | Cisplatin | en_US |
dc.subject.mesh | Coordination complexes | en_US |
dc.subject.mesh | Dose-response relationship | en_US |
dc.subject.mesh | Drug | en_US |
dc.subject.mesh | Doxorubicin | en_US |
dc.subject.mesh | Drug screening assays | en_US |
dc.subject.mesh | Antitumor | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Jurkat cells | en_US |
dc.subject.mesh | Leukemia | en_US |
dc.subject.mesh | Palladium | en_US |
dc.subject.scopus | Centella; Asiatic Acid; Triterpene | en_US |
dc.subject.wos | Oncology | en_US |
dc.subject.wos | Pharmacology & pharmacy | en_US |
dc.title | Cytotoxic activity of novel palladium-based compounds on leukemia cell lines | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |