Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemo rhagic shock: Effect is mediated by central cholinergic activation

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dc.contributor.buuauthorSavcı, Vahide
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorÇavun, Sinan
dc.contributor.buuauthorYılmaz, M. Sertaç
dc.contributor.buuauthorUlus, İsmail H.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-9496-1475tr_TR
dc.contributor.researcheridAAC-9702-2019tr_TR
dc.contributor.researcheridAAH-1571-2021tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.researcheridAAH-1448-2021tr_TR
dc.date.accessioned2021-07-13T07:31:06Z
dc.date.available2021-07-13T07:31:06Z
dc.date.issued2003-05-09
dc.description.abstractIntravenous (i.v.) administration of cytidine-5-diphosphate choline (CDP-choline) (100, 250 and 500 mg/kg) increased blood pressure in normal rats and reversed hypotension in haemorrhagic shock. Choline (54 mg/kg; i.v.), at the dose equimolar to 250 mg/kg CDP-choline decreased blood pressure of rats in both conditions and caused the death of all hypotensive animals within 2-5 min. Equimolar dose of cytidine (124 mg/kg; i.v.) did not change cardiovascular parameters. Choline levels in plasma, lateral cerebral ventricle and hypothalamus increased after CDP-choline administration. Intracerebroventricular (i.c.v.) hemicholinium-3 pretreatment (20 mug), greatly attenuated the pressor effect of CDP-choline in both conditions. Atropine pretreatment (10 mug; i.c.v.) did not change the pressor effect of CDP-choline while mecamylamine (50 mug; i.c.v.) abolished the pressor response to drug. Besides, acetylcholine (1 mumol; i.c.v.) produced similar increases in blood pressure in normal and hypotensive conditions to that observed in CDP-choline given rats. CDP-choline (250 mg/kg, i.v.) increased plasma catecholamines and vasopressin levels but not plasma renin activity. Pretreatment of rats with either prazosin (0.5 mg/kg; i.v.) or vasopressin V-1 receptor antagonist, [beta-mercapto,beta,beta-cyclopentamethylenepropionyl(1), O-Me-Tyr(2)-Arg(8)]vasopressin (10 mug/kg; i.v.), attenuated the pressor response to CDP-choline while simultaneous administration of these antagonists before CDP-choline injection completely blocked the pressor effect. Results show that i.v. CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock. Activation of central nicotinic cholinergic mechanisms by the increases in plasma and brain choline concentrations appears to be involved in the pressor effect of this drug. Moreover, the increases in plasma catecholamines and vasopressin levels mediate these effects.en_US
dc.identifier.citationSavcı, V. vd. (2003). “Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemo rhagic shock: Effect is mediated by central cholinergic activation”. European Journal of Pharmacology, 468(2), 129-139.en_US
dc.identifier.endpage139tr_TR
dc.identifier.issn0014-2999
dc.identifier.issue2tr_TR
dc.identifier.pubmed12742520tr_TR
dc.identifier.scopus2-s2.0-0037720339tr_TR
dc.identifier.startpage129tr_TR
dc.identifier.urihttps://doi.org/10.1016/S0014-2999(03)01602-9
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014299903016029
dc.identifier.urihttp://hdl.handle.net/11452/21239
dc.identifier.volume468tr_TR
dc.identifier.wos000182964500007tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.journalEuropean Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCDP-cholineen_US
dc.subjectCholilineen_US
dc.subjectCytidineen_US
dc.subjectHaemorrhagic shocken_US
dc.subjectVasopressinen_US
dc.subjectCatecholamineen_US
dc.subjectAcetylcholine-releaseen_US
dc.subjectCerebral-ischemiaen_US
dc.subjectHemorrhagic-shocken_US
dc.subjectConscious ratsen_US
dc.subjectCiticolineen_US
dc.subjectCytidineen_US
dc.subjectTetrahydroaminoacridineen_US
dc.subjectStriatumen_US
dc.subjectHumansen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleIntravenously injected CDP-choline increases blood pressure and reverses hypotension in haemo rhagic shock: Effect is mediated by central cholinergic activationen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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