An outbreak of oropharyngeal tularaemia linked to natural spring water

dc.contributor.authorWilke, Ayşe
dc.contributor.authorMeriç, Meliha
dc.contributor.authorGrunow, Roland
dc.contributor.authorSayan, Murat
dc.contributor.authorFinke, Ernst-Jurgen
dc.contributor.authorSplettstoesser, W.
dc.contributor.authorSeibold, Erik
dc.contributor.authorErdoğan, Sarper
dc.contributor.authorErgönül, Önder
dc.contributor.authorYumuk, Zeki
dc.contributor.buuauthorGedikoğlu, Suna
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid6603407548tr_TR
dc.date.accessioned2022-04-21T13:17:30Z
dc.date.available2022-04-21T13:17:30Z
dc.date.issued2009-01
dc.description.abstractA tularaemia outbreak was investigated involving 188 suspected cases in the Kocaeli region of Turkey between December 2004 and April 2005. A case-control study comprising 135 laboratory-confirmed cases and 55 controls was undertaken to identify risk factors for the development of the outbreak and to evaluate laboratory diagnostic methods. Tularaemia was confirmed by a microagglutination test (MAT) titre of >= 1 :160 in 90 of the patients. In MAT-negative sera, 23/44 (52 %) were positive by ELISA with Francisella tularensis LPS and 1/9 (111 %) by Western blotting with this antigen. A species-specific PCR was positive in 16/25 (64 %) throat swabs and 8/13 (62 %) lymph node aspirates. Multivariate analysis showed that drinking natural spring water was the leading risk factor for the development of tularaemia (P=0.0001, odds ratio 0.165, 95 % CI 0.790-0.346). The outbreak ceased after abandonment of the suspected natural water springs.en_US
dc.identifier.citationWilke, A. vd. (2009). "An outbreak of oropharyngeal tularaemia linked to natural spring water". Journal of Medical Microbiology, 58(1), 112-116.en_US
dc.identifier.endpage116tr_TR
dc.identifier.issn0022-2615
dc.identifier.issue1tr_TR
dc.identifier.pubmed19074661tr_TR
dc.identifier.scopus2-s2.0-58149522614tr_TR
dc.identifier.startpage112tr_TR
dc.identifier.urihttps://doi.org/10.1099/jmm.0.002279-0
dc.identifier.urihttps://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.002279-0
dc.identifier.urihttp://hdl.handle.net/11452/25973
dc.identifier.volume58tr_TR
dc.identifier.wos000262314400014tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherMicrobiologyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalJournal of Medical Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMATen_US
dc.subjectMicroagglutination testen_US
dc.subjectTurkeyen_US
dc.subjectMicrobiologyen_US
dc.subject.emtreeAntigenen_US
dc.subject.emtreeCeftriaxoneen_US
dc.subject.emtreeDrinking wateren_US
dc.subject.emtreeLipopolysaccharideen_US
dc.subject.emtreeMacrolideen_US
dc.subject.emtreePenicillin Gen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgglutination testen_US
dc.subject.emtreeAntibody titeren_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCase control studyen_US
dc.subject.emtreeConfidence intervalen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDifferential diagnosisen_US
dc.subject.emtreeDisease courseen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeEpidemicen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFrancisella tularensisen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInfection risken_US
dc.subject.emtreeLaboratory diagnosisen_US
dc.subject.emtreeLymph node biopsyen_US
dc.subject.emtreeLymphadenitisen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMultivariate analysisen_US
dc.subject.emtreeOropharyngeal tularemiaen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeSpecies differenceen_US
dc.subject.emtreeSpringen_US
dc.subject.emtreeStatistical significanceen_US
dc.subject.emtreeThroat cultureen_US
dc.subject.emtreeTonsillitisen_US
dc.subject.emtreeTularemiaen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeWater analysisen_US
dc.subject.emtreeWestern blottingen_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-bacterial agentsen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshDisease outbreaksen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshOropharynxen_US
dc.subject.meshTularemiaen_US
dc.subject.meshTurkeyen_US
dc.subject.meshWater microbiologyen_US
dc.subject.scopusFrancisella Tularensis; Tularemia; Animalsen_US
dc.subject.wosMicrobiologyen_US
dc.titleAn outbreak of oropharyngeal tularaemia linked to natural spring wateren_US
dc.typeArticle
dc.wos.quartileQ3en_US

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