Association of tnf-alpha-308 polymorphism with the outcome of hepatitis B virus infection in Turkey

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dc.contributor.authorKarasu, Zeki
dc.contributor.authorBaştürk, Bilkay
dc.contributor.authorKılıç, Murat
dc.contributor.authorUlukaya, Sezgin
dc.contributor.authorBoyacıoğlu, Ahmet Sedat
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı İmmünoloji Ünitesi.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.date.accessioned2022-02-14T11:19:05Z
dc.date.available2022-02-14T11:19:05Z
dc.date.issued2008-01
dc.description.abstractBackground and aim: Cytokines play important roles in the regulation of immune response. The aim of the study was to investigate the association of the cytokine gene polymorphisms with persistence of hepatitis B virus (HBV) infection and the development of end-stage liver disease (ESLD) due to HBV infection. Methods: The study involved 27 patients with end-stage liver disease due to HBV infection, 23 HBV carriers and 60 healthy controls. All genotyping (TNF-alpha, TGF-beta, IL-10, IFN-gamma) experiments were performed using sequence specific primers (PCR-SSP) by using commercial kit according to manufacturers' instructions. Results: The frequencies of TNF-alpha -308 G/G and TGF-beta 1 codon 10-25 T/C-G/G polymorphisms were significantly higher in HBV-infected individuals (patients + carriers) when compared with those of healthy controls (p: 0.02 and p: 0.004, respectively). The frequency of TNF-alpha -308 G/G polymorphism was significantly higher in the patients than those of the healthy controls (p: 0.02), whereas the frequency of TGF-beta 1 codon 10-25 T/T-G/G polymorphism was lower (p: 0.028). On the other hand, TNF-alpha -308 G/G and TGF-beta codon 10-25 T/C-G/G polymorphisms were significantly more common in HBV carriers than the control group (p: 0.017 andp: 0.018, respectively). In addition, TNF-alpha -308 G allele frequency was significantly more common in HBV-infected individuals (patients + carriers) than those of healthy controls (p: 0.0007). TNF-alpha -308 G allele frequency was also found to be higher in patients or carriers when compared with those of healthy controls (p: 0.01 and p: 0.01, respectively). Statistically significant differences were still kept after Bonferroni correction of the p-values for only TNF-alpha -308 G allele frequency in patients or carriers (Pc). Conclusion: Our study suggests that TNF-alpha gene polymorphism in patients infected with HBV would result in relatively inefficient inhibition of HBV and development of ESLD, and therefore, may be valuable predictor determinants for the development of ESLD in patients with chronic HBV infection.en_US
dc.identifier.citationBaştürk, B. vd. (2008). ''Association of TNF-alpha-308 polymorphism with the outcome of hepatitis B virus infection in Turkey''. Infection Genetics and Evolution, 8(1). 20-25.en_US
dc.identifier.endpage25tr_TR
dc.identifier.issn1567-1348
dc.identifier.issn1567-7257
dc.identifier.issue1tr_TR
dc.identifier.pubmed17974504tr_TR
dc.identifier.scopus2-s2.0-36749082117tr_TR
dc.identifier.startpage20tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.meegid.2007.09.001
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1567134807001335
dc.identifier.urihttp://hdl.handle.net/11452/24455
dc.identifier.volume8tr_TR
dc.identifier.wos000252940900003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalInfection Genetics and Evolutionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatitis B virusen_US
dc.subjectCytokinesen_US
dc.subjectGene polymorphismsen_US
dc.subjectHepatic failureen_US
dc.subjectHepatitis Ben_US
dc.subjectNecrosis-factor-alphaen_US
dc.subjectInterleukin-10 gene promoteren_US
dc.subjectAllele frequenciesen_US
dc.subjectT-cellsen_US
dc.subjectClearanceen_US
dc.subjectCytokinesen_US
dc.subjectCytokinesen_US
dc.subjectProgressionen_US
dc.subjectPopulationen_US
dc.subjectTgf-beta-1en_US
dc.subjectInfectious diseasesen_US
dc.subjectHepatic failureen_US
dc.subject.emtreeCytokineen_US
dc.subject.emtreeCytosineen_US
dc.subject.emtreeGamma interferonen_US
dc.subject.emtreeGuanineen_US
dc.subject.emtreeInterleukin 10en_US
dc.subject.emtreeInterleukin 6en_US
dc.subject.emtreeThymineen_US
dc.subject.emtreeTransforming growth factor betaen_US
dc.subject.emtreeTumor necrosis factor alphaen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeCodonen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDNA polymorphismen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHepatitis ben_US
dc.subject.emtreeHepatitis b virusen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLiver failureen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePersistent infectionen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeVirus carrieren_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic predisposition to diseaseen_US
dc.subject.meshHepatitis b virusen_US
dc.subject.meshHepatitis ben_US
dc.subject.meshChronicen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymorphism, geneticen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTumor necrosis factor-alphaen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusChronic Hepatitis B; HLA Antigen; Hepatitis C Virusen_US
dc.subject.wosInfectious diseasesen_US
dc.titleAssociation of tnf-alpha-308 polymorphism with the outcome of hepatitis B virus infection in Turkeyen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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