Association of tnf-alpha-308 polymorphism with the outcome of hepatitis B virus infection in Turkey
dc.contributor.author | Karasu, Zeki | |
dc.contributor.author | Baştürk, Bilkay | |
dc.contributor.author | Kılıç, Murat | |
dc.contributor.author | Ulukaya, Sezgin | |
dc.contributor.author | Boyacıoğlu, Ahmet Sedat | |
dc.contributor.buuauthor | Oral, Haluk Barbaros | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı İmmünoloji Ünitesi. | tr_TR |
dc.contributor.orcid | 0000-0003-0463-6818 | tr_TR |
dc.contributor.researcherid | K-7285-2012 | tr_TR |
dc.contributor.scopusid | 7004498001 | tr_TR |
dc.date.accessioned | 2022-02-14T11:19:05Z | |
dc.date.available | 2022-02-14T11:19:05Z | |
dc.date.issued | 2008-01 | |
dc.description.abstract | Background and aim: Cytokines play important roles in the regulation of immune response. The aim of the study was to investigate the association of the cytokine gene polymorphisms with persistence of hepatitis B virus (HBV) infection and the development of end-stage liver disease (ESLD) due to HBV infection. Methods: The study involved 27 patients with end-stage liver disease due to HBV infection, 23 HBV carriers and 60 healthy controls. All genotyping (TNF-alpha, TGF-beta, IL-10, IFN-gamma) experiments were performed using sequence specific primers (PCR-SSP) by using commercial kit according to manufacturers' instructions. Results: The frequencies of TNF-alpha -308 G/G and TGF-beta 1 codon 10-25 T/C-G/G polymorphisms were significantly higher in HBV-infected individuals (patients + carriers) when compared with those of healthy controls (p: 0.02 and p: 0.004, respectively). The frequency of TNF-alpha -308 G/G polymorphism was significantly higher in the patients than those of the healthy controls (p: 0.02), whereas the frequency of TGF-beta 1 codon 10-25 T/T-G/G polymorphism was lower (p: 0.028). On the other hand, TNF-alpha -308 G/G and TGF-beta codon 10-25 T/C-G/G polymorphisms were significantly more common in HBV carriers than the control group (p: 0.017 andp: 0.018, respectively). In addition, TNF-alpha -308 G allele frequency was significantly more common in HBV-infected individuals (patients + carriers) than those of healthy controls (p: 0.0007). TNF-alpha -308 G allele frequency was also found to be higher in patients or carriers when compared with those of healthy controls (p: 0.01 and p: 0.01, respectively). Statistically significant differences were still kept after Bonferroni correction of the p-values for only TNF-alpha -308 G allele frequency in patients or carriers (Pc). Conclusion: Our study suggests that TNF-alpha gene polymorphism in patients infected with HBV would result in relatively inefficient inhibition of HBV and development of ESLD, and therefore, may be valuable predictor determinants for the development of ESLD in patients with chronic HBV infection. | en_US |
dc.identifier.citation | Baştürk, B. vd. (2008). ''Association of TNF-alpha-308 polymorphism with the outcome of hepatitis B virus infection in Turkey''. Infection Genetics and Evolution, 8(1). 20-25. | en_US |
dc.identifier.endpage | 25 | tr_TR |
dc.identifier.issn | 1567-1348 | |
dc.identifier.issn | 1567-7257 | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 17974504 | tr_TR |
dc.identifier.scopus | 2-s2.0-36749082117 | tr_TR |
dc.identifier.startpage | 20 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.meegid.2007.09.001 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1567134807001335 | |
dc.identifier.uri | http://hdl.handle.net/11452/24455 | |
dc.identifier.volume | 8 | tr_TR |
dc.identifier.wos | 000252940900003 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Infection Genetics and Evolution | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Hepatitis B virus | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Gene polymorphisms | en_US |
dc.subject | Hepatic failure | en_US |
dc.subject | Hepatitis B | en_US |
dc.subject | Necrosis-factor-alpha | en_US |
dc.subject | Interleukin-10 gene promoter | en_US |
dc.subject | Allele frequencies | en_US |
dc.subject | T-cells | en_US |
dc.subject | Clearance | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Progression | en_US |
dc.subject | Population | en_US |
dc.subject | Tgf-beta-1 | en_US |
dc.subject | Infectious diseases | en_US |
dc.subject | Hepatic failure | en_US |
dc.subject.emtree | Cytokine | en_US |
dc.subject.emtree | Cytosine | en_US |
dc.subject.emtree | Gamma interferon | en_US |
dc.subject.emtree | Guanine | en_US |
dc.subject.emtree | Interleukin 10 | en_US |
dc.subject.emtree | Interleukin 6 | en_US |
dc.subject.emtree | Thymine | en_US |
dc.subject.emtree | Transforming growth factor beta | en_US |
dc.subject.emtree | Tumor necrosis factor alpha | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Codon | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | DNA polymorphism | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Gene frequency | en_US |
dc.subject.emtree | Genotype | en_US |
dc.subject.emtree | Hepatitis b | en_US |
dc.subject.emtree | Hepatitis b virus | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Liver failure | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Persistent infection | en_US |
dc.subject.emtree | Polymerase chain reaction | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Turkey (republic) | en_US |
dc.subject.emtree | Virus carrier | en_US |
dc.subject.mesh | Disease Progression | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Genetic predisposition to disease | en_US |
dc.subject.mesh | Hepatitis b virus | en_US |
dc.subject.mesh | Hepatitis b | en_US |
dc.subject.mesh | Chronic | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Polymorphism, genetic | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Tumor necrosis factor-alpha | en_US |
dc.subject.mesh | Turkey | en_US |
dc.subject.scopus | Chronic Hepatitis B; HLA Antigen; Hepatitis C Virus | en_US |
dc.subject.wos | Infectious diseases | en_US |
dc.title | Association of tnf-alpha-308 polymorphism with the outcome of hepatitis B virus infection in Turkey | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |
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