MikroRNA’lar (miRNA) ve kanser
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Date
2014-10-01
Authors
Bağcı, Özkan
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
mikroRNA’lar (miRNA) bitkiler, hayvanlar ve bazı virüslerde gen ifadesini düzenleyen, protein kodlamayan küçük ve kısa RNA’lardır. miRNA’lar, protein kodlayan genlerin transkriptleri olan hedef mRNA’lara bağlanabilirler ve translasyonu negatif olarak regüle edebildikleri gibi, mRNA’ları degradasyona uğratarak da işlev gösterebilirler. miRNA’lar apoptoz, kök hücrelerin farklılaşması, hücre siklusunun regülasyonu ve kanser patogenezi gibi birçok biolojik süreçte işlev gösterebilmektedirler. Karsinogenez süreci ile ilişkili miRNA’lar hedef aldıkları mRNA’lara göre tümör baskılayıcı veya onkojenik özellik gösterebilirler. Bu derlemede kanserin patogenezinde epigenetik mekanizmalardan miRNA’ların etkisi tartışılmıştır.
microRNAs (miRNA) are small and short, non-coding RNAs that regulate gene expression in plants, animals and some viruses. miRNAs can bind to target messenger RNA (mRNA) transcripts of protein-coding genes and negatively control their translation or cause mRNA degradation. miRNAs such as apoptosis, differentiation of stem cells, cell cycle regulation and the pathogenesis of cancer may act in many biological processes. miRNAs associated with process of carcinogenesis may function tumor suppressor or oncogenic, according to their mRNA targets. In this review, the effect of miRNAs from epigenetic mechanisms in the pathogenesis of cancer is discussed.
microRNAs (miRNA) are small and short, non-coding RNAs that regulate gene expression in plants, animals and some viruses. miRNAs can bind to target messenger RNA (mRNA) transcripts of protein-coding genes and negatively control their translation or cause mRNA degradation. miRNAs such as apoptosis, differentiation of stem cells, cell cycle regulation and the pathogenesis of cancer may act in many biological processes. miRNAs associated with process of carcinogenesis may function tumor suppressor or oncogenic, according to their mRNA targets. In this review, the effect of miRNAs from epigenetic mechanisms in the pathogenesis of cancer is discussed.
Description
Keywords
miRNA, miRNA, Kanser, Epigenetik, Cancer, Epigenetics
Citation
Bağcı Ö. (2014). "MikroRNA’lar (miRNA) ve kanser" Uludağ Üniversitesi Tıp Fakültesi Dergisi, 40(2),105-109.