Toll-like receptor 9 polymorphism in patients with erythema multiforme, Stevens Johnson syndrome and Stevens Johnson syndrome/toxic epidermal necrolysis overlap syndrome

dc.contributor.buuauthorTuran, Hakan
dc.contributor.buuauthorBaşkan, Emel Bülbül
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorKarkucak, Mutlu
dc.contributor.buuauthorTunali, Şükran
dc.contributor.buuauthorSarıcaoğlu, Hayriye
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genetik Tıp Anabilim Dalı.tr_TR
dc.contributor.scopusid16835681500tr_TR
dc.contributor.scopusid43760921800tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid35388323500tr_TR
dc.contributor.scopusid7004191748tr_TR
dc.contributor.scopusid6603722836tr_TR
dc.date.accessioned2022-03-18T07:30:12Z
dc.date.available2022-03-18T07:30:12Z
dc.date.issued2011
dc.description.abstractBackground: "Toll like receptor" (TLR) 9 functions in stepping in of native immune system against different viral and bacterial pathogens and induction of adaptive immune response effectively. TLR 9 gene polymorphism makes host predisposed to microbial pathogens by affecting the functional capabilities of the receptor. Objective: We aimed to determine if TLR 9 gene polymorphism makes a predisposition to "erythema multiforme" (EM), "Stevens Johnson syndrome" (SJS) and "Stevens Johnson syndrome/toxic epidermal necrolysis overlap syndrome" (SJS/TEN). Methods: Forty-two patients clinically and/or histopathologically diagnosed as EM, SJS, and SJS/TEN overlap syndrome and 50 healthy control subjects were enrolled in our study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was applied for TLR 9 gene 1237 thymine/cytosine (T/C) polymorphism. Genotypes were determined according to bands occurring on agarose gel electrophoresis. Results: In patients group, the frequencies of IT and TC genotypes were 73.8 % and 26.2 % while CC genotype wasn't detected. In control group, the frequencies of TT, TC and CC genotypes were 74 %, 24 %, and 2 %. There wasn't a statistically significant difference for TT, TC and CC genotypes between patients and controls. The frequencies of T and C alleles were 84.5 % and 15.5 % in patients and 86 % and 14 % in controls, respectively. Conclusion: Our results showed that there isn't any association between TLR gene polymorphism and EM, SJS, SJS/TEN overlap syndrome (Tab. 1, Fig. 1, Ref. 30).en_US
dc.identifier.citationTuran, H. vd.(2011). "Toll-like receptor 9 polymorphism in patients with erythema multiforme, Stevens Johnson syndrome and Stevens Johnson syndrome/toxic epidermal necrolysis overlap syndrome". Bratislava Medical Journal-Bratislavske Lekarske Listy, 112(5), 260-263.en_US
dc.identifier.endpage263tr_TR
dc.identifier.issn0006-9248
dc.identifier.issue5tr_TR
dc.identifier.pubmed21682079tr_TR
dc.identifier.scopus2-s2.0-79957924998tr_TR
dc.identifier.startpage260tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/25172
dc.identifier.volume112tr_TR
dc.identifier.wos000290424100006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.journalBratislava Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectErythema multiformeen_US
dc.subjectStevens Johnson syndromeen_US
dc.subjectStevens Johnson syndrome/toxic epidermal necrolysis overlap syndromeen_US
dc.subjectToll like receptor 9en_US
dc.subjectPolymorphismen_US
dc.subjectSingle-nucleotide polymorphismsen_US
dc.subjectSystemic-lupus-erythematosusen_US
dc.subjectDermatological diseaseen_US
dc.subjectGene polymorphismen_US
dc.subjectJapanese patientsen_US
dc.subjectDrosophila tollen_US
dc.subjectAssociationen_US
dc.subjectTlr9en_US
dc.subjectSusceptibilityen_US
dc.subjectDnaen_US
dc.subject.emtreeToll like receptor 9en_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeErythema multiformeen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGenetic polymorphismen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeImmunologyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeReverse transcription polymerase chain reactionen_US
dc.subject.emtreeStevens Johnson syndromeen_US
dc.subject.emtreeToxic epidermal necrolysisen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChilden_US
dc.subject.meshEpidermal necrolysis, toxicen_US
dc.subject.meshErythema multiformeen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPolymorphism, geneticen_US
dc.subject.meshReverse transcriptase polymerase chain reactionen_US
dc.subject.meshStevens-Johnson syndromeen_US
dc.subject.meshToll-like receptor 9en_US
dc.subject.meshYoung adulten_US
dc.subject.scopusStevens-Johnson Syndrome; Erythema Multiforme; Acute Generalized Exanthematous Pustulosisen_US
dc.subject.wosMedicine, general & internalen_US
dc.titleToll-like receptor 9 polymorphism in patients with erythema multiforme, Stevens Johnson syndrome and Stevens Johnson syndrome/toxic epidermal necrolysis overlap syndromeen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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