Therapy, outcome and analysis of c-kit expression in patients with extrapulmonary small cell carcinoma

dc.contributor.authorSezgin, Canfeza
dc.contributor.authorVeral, Ali
dc.contributor.authorKarabulut, Bülent
dc.contributor.authorGöker, Erdem
dc.contributor.buuauthorKurt, Ender
dc.contributor.buuauthorEvrensel, Türkkan
dc.contributor.buuauthorYalçınkaya, Ülviye
dc.contributor.buuauthorKanat, Özkan
dc.contributor.buuauthorDemiray, Mutlu
dc.contributor.buuauthorArslan, Murat
dc.contributor.buuauthorErcan, İlker
dc.contributor.buuauthorManavoǧlu, Osman
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.orcid0000-0003-2501-3097tr_TR
dc.contributor.orcid0000-0002-9732-5340tr_TR
dc.contributor.researcheridM-8060-2019tr_TR
dc.contributor.researcheridAAJ-1027-2021tr_TR
dc.contributor.scopusid7006207332tr_TR
dc.contributor.scopusid6603942124tr_TR
dc.contributor.scopusid6508300295tr_TR
dc.contributor.scopusid55881548500tr_TR
dc.contributor.scopusid6603631569tr_TR
dc.contributor.scopusid57197925370tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.contributor.scopusid6602587152tr_TR
dc.date.accessioned2022-03-11T07:15:16Z
dc.date.available2022-03-11T07:15:16Z
dc.date.issued2005-05
dc.description.abstractIn this study, we aimed to investigate the clinicopathological characteristics with special emphasis on c-kit expression and the treatment results of patients with extrapulmonary small cell carcinoma (EPSCC). The medical records of the patients with EPSCC were reviewed, and the data regarding patient and tumour characteristics, treatment and clinical outcome were retrieved and analysed. A total of 28 patients with the diagnosis of EPSCC were identified. There were 19 males and 9 females, with a mean age of 56.5 years. Patients with limited disease (LD) (n = 13) were treated with surgery, chemotherapy (CT) and radiotherapy with different sequences. Patients with extensive disease (ED) (n = 15) were mainly treated with combination CT. The median overall survival was 14.5 months in patients with LD compared to 11 months in those with ED (p = 0.029). Ten patients (36%) showed c-kit overexpression. There was no significant difference between the survival of c-kit-positive and c-kit-negative patients (p = 0.367). In conclusion, our study demonstrates that the prognosis of EPSCC is poor despite currently available treatments. C-kit may be considered as a potential target for novel therapeutical approaches.en_US
dc.identifier.citationKurt, E. vd. (2005). "Therapy, outcome and analysis of c-kit expression in patients with extrapulmonary small cell carcinoma". International Journal of Clinical Practice, 59(5), 537-543.en_US
dc.identifier.endpage543tr_TR
dc.identifier.issn1368-5031
dc.identifier.issue5tr_TR
dc.identifier.pubmed15857349tr_TR
dc.identifier.scopus2-s2.0-27144466420tr_TR
dc.identifier.startpage537tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1368-5031.2005.00447.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1368-5031.2005.00447.x
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/15857349/
dc.identifier.urihttp://hdl.handle.net/11452/24943
dc.identifier.volume59tr_TR
dc.identifier.wos000228307200008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectExtrapulmonaryen_US
dc.subjectSmall cell carcinomaen_US
dc.subjectTherapyen_US
dc.subjectC-kiten_US
dc.subjectSingle-institution experienceen_US
dc.subjectLung-canceren_US
dc.subjectProtein expressionen_US
dc.subjectPhase-IIen_US
dc.subjectChemotherapyen_US
dc.subjectBladderen_US
dc.subjectOverexpressionen_US
dc.subjectPrognosisen_US
dc.subjectDiagnosisen_US
dc.subjectImatiniben_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeCarboplatinen_US
dc.subject.emtreeCisplatinen_US
dc.subject.emtreeCyclophosphamideen_US
dc.subject.emtreeDoxorubicinen_US
dc.subject.emtreeEpirubicinen_US
dc.subject.emtreeEtoposideen_US
dc.subject.emtreeFluorouracilen_US
dc.subject.emtreeIfosfamideen_US
dc.subject.emtreePaclitaxelen_US
dc.subject.emtreeStem cell factor receptoren_US
dc.subject.emtreeTopotecanen_US
dc.subject.emtreeVincristineen_US
dc.subject.emtreeStem cell factor receptoren_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer survivalen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeClinical featureen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDemographyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeKaplan meier methoden_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMedical recorden_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeSmall cell carcinomaen_US
dc.subject.emtreeTreatment outcomeen_US
dc.subject.emtreeAdjuvant chemotherapyen_US
dc.subject.emtreeAdjuvant therapyen_US
dc.subject.emtreeDisease free survivalen_US
dc.subject.emtreeGastrointestinal tumoren_US
dc.subject.emtreeGene expressionen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.emtreeSmall cell carcinomaen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, small cellen_US
dc.subject.meshChemotherapy, adjuvanten_US
dc.subject.meshDisease-free survivalen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal neoplasmsen_US
dc.subject.meshGene expressionen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshProto-oncogene proteins c-kiten_US
dc.subject.meshRadiotherapy, adjuvanten_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.scopusSmall Cell Carcinoma; Neuroendocrine Carcinoma; Esophagusen_US
dc.subject.wosMedicine, general & internalen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleTherapy, outcome and analysis of c-kit expression in patients with extrapulmonary small cell carcinomaen_US
dc.typeArticle
dc.wos.quartileQ2en_US

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: