Angiotensin-II receptor antagonist losartan reduces micro albuminuria in hypertensive renal transplant recipients
dc.contributor.buuauthor | Alparslan, Ersoy | |
dc.contributor.buuauthor | Dilek, Kamil | |
dc.contributor.buuauthor | Usta, Mehmet | |
dc.contributor.buuauthor | Yavuz, Mahmut | |
dc.contributor.buuauthor | Güllülü, Mustafa | |
dc.contributor.buuauthor | Yurtkuran, Mustafa Abbas | |
dc.contributor.buuauthor | Oktay, Burçin | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-0710-0923 | tr_TR |
dc.contributor.researcherid | AAH-5054-2021 | tr_TR |
dc.contributor.scopusid | 35612977100 | tr_TR |
dc.contributor.scopusid | 56005080200 | tr_TR |
dc.contributor.scopusid | 7005030712 | tr_TR |
dc.contributor.scopusid | 7006244754 | tr_TR |
dc.contributor.scopusid | 6602684544 | tr_TR |
dc.contributor.scopusid | 6602172127 | tr_TR |
dc.contributor.scopusid | 7003389525 | tr_TR |
dc.date.accessioned | 2022-03-14T08:22:38Z | |
dc.date.available | 2022-03-14T08:22:38Z | |
dc.date.issued | 2002-06 | |
dc.description.abstract | In recent years, it has been demonstrated that losartan lowers macroproteinuria in diabetic or non-diabetic renal transplant recipients (RTx) similar to angiotensin converting enzyme (ACE) inhibitors. Microalbuminuria (MAU) may reflect subclinical hyperfiltration damage of the glomerulus. It could be a marker of kidney dysfunction in renal transplantation. The aim of the study was to assess the efficacy of losartan in hypertensive RTx with MAU. This study was conducted in 17 (M/F: 4/13) stable RTx. No change was made in the medical treatment of the patients. All cases received 50 mg/day losartan therapy for 12 wk. Renal functions and MAU were determined 12 and 6 wk and just before the treatment as well as sixth and twelfth week of the treatment in all patients. Losartan satisfactorily lowered systemic blood pressure. A significant reduction in MAU was observed from 103 +/- 53 mug/min at the beginning to 59 +/- 25 mug/min in the sixth week and 47 +/- 24 mug/min in the twelfth week (p = 0.0007 and 0.0005, respectively). From the sixth week of the treatment, the therapy significantly decreased hemoglobin, hematocrit and erythrocyte levels but did not change mean leukocyte and platelet counts, urea, creatinine levels and creatinine clearances. No serious side-effect was observed,during the study. In conclusion, we found that losartan decreased MAU in hypertensive RTx. For that reason, it might be considered as the first choise antihypertensive agent for the renoprotection in selected patients. | en_US |
dc.identifier.citation | Ersoy, A. vd. (2002). "Angiotensin-II receptor antagonist losartan reduces micro albuminuria in hypertensive renal transplant recipients". Clinical Transplantation, 16(3), 202-205. | en_US |
dc.identifier.endpage | 205 | tr_TR |
dc.identifier.issn | 0902-0063 | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.pubmed | 12010144 | tr_TR |
dc.identifier.scopus | 2-s2.0-0036308902 | tr_TR |
dc.identifier.startpage | 202 | tr_TR |
dc.identifier.uri | https://doi.org/10.1034/j.1399-0012.2002.01127.x | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1034/j.1399-0012.2002.01127.x | |
dc.identifier.uri | http://hdl.handle.net/11452/24979 | |
dc.identifier.volume | 16 | tr_TR |
dc.identifier.wos | 000176236300009 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | Clinical Transplantation | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Renoprotection | en_US |
dc.subject | Angiotensin II receptor blockade | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Kidney transplantation | en_US |
dc.subject | Losartan | en_US |
dc.subject | Microalbuminuria | en_US |
dc.subject | Disease | en_US |
dc.subject | Cyclosporine | en_US |
dc.subject | Nephropathy | en_US |
dc.subject | Protein | en_US |
dc.subject | Failure | en_US |
dc.subject.emtree | Albumin | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Adolescent | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Controlled clinical trial | en_US |
dc.subject.emtree | Renovascular hypertension | en_US |
dc.subject.emtree | Blood pressure | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Clinical feature | en_US |
dc.subject.emtree | Clinical trial | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Thrombocyte count | en_US |
dc.subject.emtree | Disease marker | en_US |
dc.subject.emtree | Coughing | en_US |
dc.subject.emtree | Kidney transplantation | en_US |
dc.subject.emtree | Drug choice | en_US |
dc.subject.emtree | Immunosuppressive treatment | en_US |
dc.subject.emtree | Creatinine clearance | en_US |
dc.subject.emtree | Diabetes mellitus dose response | en_US |
dc.subject.emtree | Drug blood level | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Drug efficacy | en_US |
dc.subject.emtree | Erythrocyte level | en_US |
dc.subject.emtree | Hematocrit | en_US |
dc.subject.emtree | Glomerulonephritis | en_US |
dc.subject.emtree | Glomerulus filtration | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Hemoglobin determination | en_US |
dc.subject.emtree | Hypotension | en_US |
dc.subject.emtree | Kidney dysfunction | en_US |
dc.subject.emtree | Kidney function test | en_US |
dc.subject.emtree | Leukocyte count | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Microalbuminuria | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Poteinuria | en_US |
dc.subject.emtree | Recipient | en_US |
dc.subject.emtree | Albumin | en_US |
dc.subject.emtree | Angiotensin 2 receptor antagonist | en_US |
dc.subject.emtree | Antihypertensive agent | en_US |
dc.subject.emtree | Azathioprine | en_US |
dc.subject.emtree | Calcium | en_US |
dc.subject.emtree | Calcium channel blocking agent | en_US |
dc.subject.emtree | Chloride | en_US |
dc.subject.emtree | Creatinine | en_US |
dc.subject.emtree | Cyclosporin A | en_US |
dc.subject.emtree | Dipeptidyl carboxypeptidase inhibitor | en_US |
dc.subject.emtree | Diuretic agent | en_US |
dc.subject.emtree | Hemoglobin | en_US |
dc.subject.emtree | Immunosuppressive agent | en_US |
dc.subject.emtree | Losartan | e |
dc.subject.emtree | Phosphorus | en_US |
dc.subject.emtree | Potassium | e |
dc.subject.emtree | Prednisolone | en_US |
dc.subject.emtree | Sodium | en_US |
dc.subject.emtree | Urea | en_US |
dc.subject.emtree | Uric acid | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Angiotensin II | en_US |
dc.subject.mesh | Albuminuria | en_US |
dc.subject.mesh | Antihypertensive agents | en_US |
dc.subject.mesh | Blood pressure | en_US |
dc.subject.mesh | Losartan | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hypertension | en_US |
dc.subject.mesh | Kidney transplantation | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.scopus | Kidney Transplantation; Transplant Recipients; Ambulatory Blood Pressure Monitoring | en_US |
dc.subject.wos | Surgery | en_US |
dc.subject.wos | Transplantation | en_US |
dc.title | Angiotensin-II receptor antagonist losartan reduces micro albuminuria in hypertensive renal transplant recipients | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 (Surgery) | en_US |
dc.wos.quartile | Q3 (Transplantation) | en_US |