Effect of long-term centrally ınjected histamine and ıts receptors antagonist on the hypothalamic cyclooxygenase and lipoxygenase enzymes in rats

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dc.contributor.authorAltınbaş, Burçin
dc.contributor.buuauthorBaş, Ayşenur
dc.contributor.buuauthorBayram, Gökçen Güvenç
dc.contributor.buuauthorÖzyurt, Ebru
dc.contributor.buuauthorYalçın, Ebru
dc.contributor.buuauthorTepedelen, Burcu Erbaykent
dc.contributor.buuauthorErsoy, Figen
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.contributor.departmentBursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Moleküler Biyoloji ve Genetik Bölümü.tr_TR
dc.contributor.orcid0000-0002-7825-4823tr_TR
dc.contributor.orcid0000-0002-1413-3651tr_TR
dc.contributor.orcid0000-0003-1591-510Xtr_TR
dc.contributor.orcid0000-0003-1591-510Xtr_TR
dc.contributor.orcid0000-0003-1591-510Xtr_TR
dc.contributor.orcid0000-0003-1591-510Xtr_TR
dc.contributor.orcid0000-0003-1756-1288tr_TR
dc.date.accessioned2020-12-21T12:44:42Z
dc.date.available2020-12-21T12:44:42Z
dc.date.issued2019-10-01
dc.description.abstractThe current study was designed to determine the effect of centrally chronic-administrated histamine and histaminergic receptors antagonist on the level of hypothalamic cyclooxygenase (COX) and lipoxygenase (LOX) enzymes. Studies were performed in male Sprague–Dawley rats. Histamine (100 nmol), histaminergic H1 receptor antagonist chlorpheniramine (100 nmol), histaminergic H2 receptor antagonist ranitidine (100 nmol) or histaminergic H3/H4 receptor antagonist thioperamide (100 nmol) was injected intracerebroventricularly for 7 days. Central chronic histamine treatment caused increases in the levels of all three enzymes in the hypothalamus. Central chronic treatments with all three histaminergic receptors antagonists reduced the hypothalamic COX-1 levels and raised the hypothalamic COX-2 and LOX levels. In conclusion, our findings show that the central histamine has a possible role to affect the central COX and LOX pathways. This could be interpreted as that central histaminergic system might have a potential to activate central COX and LOX pathways to regulate central nervous system functions.en_US
dc.identifier.citationBaş, A. vd. (2019). "Effect of long-term centrally ınjected histamine and ıts receptors antagonist on the hypothalamic cyclooxygenase and lipoxygenase enzymes in rats". Bursa Uludağ Üniversitesi Veteriner Fakültesi, 38(2), 10-16.tr_TR
dc.identifier.endpage16tr_TR
dc.identifier.issn1301-3173
dc.identifier.issue2tr_TR
dc.identifier.startpage10tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/891647
dc.identifier.urihttp://hdl.handle.net/11452/14517
dc.identifier.volume38tr_TR
dc.language.isoenen_US
dc.publisherBursa Uludağ Üniversitesitr_TR
dc.relation.collaborationYurtiçi.tr_TR
dc.relation.journalVeteriner Hekimlikte Araştırma Dergisi / Journal of Research in Veterinary Medicinetr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHistamineen_US
dc.subjectHistaminergic receptorsen_US
dc.subjectHypothalamusen_US
dc.subjectCyclooxygenaseen_US
dc.subjectLipoxygenaseen_US
dc.subjectIntracerebroventricularen_US
dc.subjectWestern blot.en_US
dc.titleEffect of long-term centrally ınjected histamine and ıts receptors antagonist on the hypothalamic cyclooxygenase and lipoxygenase enzymes in ratsen_US
dc.typeArticleen_US

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2019 Cilt 38 Sayı 2