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Recent Submissions
Changes in agricultural and technologic characteristics of some basil (ocimumbasilicuml.) genotypes at different plant growth stages and harvest periods
(Pakistan Botanical Soc, 2024-06-01) Kacar, Oya; Ozer, Perihan Ceren; Sari, Yusuf; KAÇAR, OYA
The purpose of this study was to assess the changes in yield, essential oil content, and composition of some basil genotypes during different growth stages. The research was conducted at Bursa Uludag University, Faculty of Agriculture, Department of Field Crops, in Turkey. Three basil genotypes (Largesweet, Midnight, and Malatya), three growth phases (the beginning of flowering, the 50% flowering, the end of flowering), and harvest numbers (1(st) harvest and 2(nd) harvest) were examined as variables in this study. A field trial was conducted using a three-level factorial randomized complete block design with three replications. For each growth stage, two harvests were made throughout the vegetation season. As a result of the study, the Malatya genotype showed to have greater values in terms of plant height, totally fresh, dry herb, and dry leaf yields (53.85 cm, 2224.03 kg da(-1), 334.75 kg da(-1), 157.01 kg da(-1), respectively) than other genotypes, whereas the Largesweet genotype had higher values in terms of essential oil content (0.53%). Higher values of agricultural characteristics were achieved in general at 50% flowering condition. The essential oil ratio was increased towards the end of flowering period. In all aspects, the 1(st) harvest outperformed the 2(nd) harvest. In terms of essential oil composition, Largesweet and Midnight cultivars were found to be of the linalool chemotype, while the Malatya genotype was of the linalool/methyl cinnamate Z chemotype.
Two new grave stelae from görükle
(Mersin Univ Publ Res Center Cilician Archaeology, 2024-01-01) Arcagok, Ibrahim; Sahin, Mustafa; SAĞLIK, ÖZHAN
In this article two grave stelae which were found in 2021 in Gorukle by Nilufer belonging to the province of Bursa will be introduced. One of them was found abandoned at the Gorukle Campus of the Bursa Uludag University, and the other was obtained by chance during construction excavations in Gorukle's Kurtulus District. These grave stelae will be discussed in terms of their iconography, possible workshops and chronology. In the iconography section, we will refer to important publications on the subject. Furthermore the eagle issue, which we think is closely related to the Roman Imperial cult, will be examined comprehensively. The first grave stele, which we date between 130 - 120 BC due to its stylistic features, is the earliest dated grave stele from Myrleia / Apameia. The fact that similar furniture types in the banquet scene are found on the grave stelae of Nikomedeia and Nikaia suggests that this stele was produced by a workshop in Central Bithynia. The phrase of the second grave stele "The People of Apameia" on the stele of Apollophanes and Metrophila, dated to the middle of the 2nd century AD, is important in terms of showing that the territories of the city of Myrleia / Apameia extended to modern Gorukle. The eagle with open wings depicted on this grave stele is noteworthy as it indicates that the local population was interested in Roman culture as a result of the colonization of the city by Iulius Caesar c. 49-44 BC.
Effect of washing method on the reduction of insecticide residues and quality characteristics of sweet cherry fruits
(Entomological Soc Turkey, Ege Univ, 2024-01-01) Hazarhun, Gulden; Kumral, Nabi Alper; Gumul, Burcu; Kolcu, Aysenur; Ertas, Simge; Sağlık, Özhan; SAĞLIK, ÖZHAN
Sweet cherry trees were sprayed with 5 insecticides (acetamiprid, dimethoate, lambda-cyhalothrin, malathion, tau-fluvalinate) at the recommended field doses in this study. Fruits were harvested after the pre-harvested interval for each pesticide completed and then they were immersed into tap water and three different washing solutions (with three different concentrations) for 3 minutes (at 20(o)C). Insecticide concentrations were detected with a multi-residual analysis method using LC-MS/MS in Bursa Uludag University in 2022. Following the treatments, changes in the quality characteristics of fruits were also investigated by quality (colour, texture and fruit cracking rate, water-soluble dry matter) and sensory analysis (fruit and stem colour, firmness, appearance, general acceptability). The results revealed that washing method with tap water during 3 min decreased insecticide residue level by 7-45% depending on insecticide active compound. Higher reduction rates were observed by washing with citric acid (10%), sodium bicarbonate (2.5%) and sodium hydroxide (0.5%). But significant reductions were detected only in lambda-cyhalothrin and malathion residues when compared with the newly harvested fruit samples. Processing factors (PF) of all washing methods were generally lower than 1 except for three treatments. PF values showed variations depending on the type of washing solution and the active compound of insecticides. Although washing with citric acid (10%), sodium bicarbonate (2.5%) and sodium hydroxide (0.5%) solutions caused reduction in residue levels, their negative effects on the quality and sensory characteristics of the fruits cannot be ruled out.
Talazoparib loaded solid lipid nanoparticles: Preparation, characterization and evaluation of the therapeutic efficacy in vitro
(Bentham Science Publisher, 2019) Eskiler, Gamze Güney; Dikmen, Gökhan; Çeçener, Gülşah; Egeli, Ünal; Tunca, Berrin; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı; 0000-0002-3820-424X; 0000-0001-7904-883X; 0000-0002-1619-6680; AAP-9988-2020; AAH-1420-2021; ABI-6078-2020; 6508156530; 55665145000; 6602965754
Objective: In the present work, we report for the first time the therapeutic potential of talazoparib (BMN 673)-SLNs for the treatment of BRCA1 deficient Triple Negative Breast Cancer (TNBC). BMN 673-SLNs were produced by hot-homogenization technique and then characterized. Methods: The cytotoxic and apoptotic effects of BMN 673-SLNs compared with BMN 673 were determined on HCC1937BRCA1-/-, HCC1937-R resistant TNBC and MCF-10A control cell lines. BMN 673- SLNs were found to have reduced particle size (219.5 ± 1.45 nm) and thus more stable (-28.4 ± 2.52 mV) than BMN 673 (1652 ± 2.46 nm and -18.6 ± 0.45 mV) at 4ºC. Results: In vitro cell line studies demonstrated that BMN 673-SLNs showed significant cytotoxic effects on HCC1937 (29.8%) and HCC1937-R cells (35.7%) at 10 nM for 12 days compared with BMN 673 (HCC1937 cells: 34.0% and HCC1937-R cells: 93.8% at 10 nM for 12 days) (p<0.05). Additionally, BMN 673-SLNs (40.1%) reduced the toxicity of BMN 673 (53.1%) on MCF-10A control cells thanks to unique physical properties. Conclusion: The apoptotic rates in the 10 nM BMN 673-SLNs treatment (88.78% and 85.56%) for 12 days were significantly higher than those in 10 nM BMN 673 (82.6% and 25.86%) for 12 days in HCC1937 and HCC1937-R cells, respectively (p<0.01). Furthermore, these effects were consistent with the findings of colony formation, wound healing and calcein accumulation analysis. In conclusion, the therapeutic potential of BMN 673-SLNs provides a promising chemotherapeutic strategy for the treatment of drugresistant TNBC.
Oleuropein modulates glioblastoma miRNA pattern different from Olea europaea leaf extract
(Sage Publications, 2019-09) Tezcan, Gülçin; Aksoy, Seçil Ak; Tunca, Seçil Berrin; Bekar, Ahmet; Mutlu, Melis; Çeçener, Gülşah; Egeli, Ünal; Kocaeli, Hasan; Demirci, Hilal; Taşkapılıoğlu, Mevlüt Özgür; Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-3760-9755; 0000-0002-1619-6680; 0000-0002-3820-424X; 0000-0001-7904-883X; 0000-0001-5472-9065; AAH-8540-2021; ABI-6078-2020; CGB-7869-2022; FPB-0403-2022; AAP-9988-2020; AAH-1420-2021; FDK-3229-2022; CNW-1571-2022; AAW-5254-2020; 36668149100; 6602965754; 6603677218; 57212065763; 6508156530; 55665145000; 6603500567; 57193932262; 25936798300
Glioblastoma (GBM) is the most prevalent and deadliest subtype of glioma. Despite current innovations in existing therapeutic modalities, GBM remains incurable, and alternative therapies are required. Previously, we demonstrated that Olea europaea leaf extract (OLE) kills GBM cells by modulating miR-181b, miR-137, miR-153 and Let-7d expression. However, although oleuropein (OL) is the main compound in OLE, its role in the antitumour effect of OLE remains unknown. This study determined the effect of OL on GBM cell line T98G and compared the results with our previous findings regarding the effect of OLE on the same cell line. The antiproliferative activity of OL and its effect on temozolomide (TMZ) response were tested inT98G cells using WST-1 assay. OL inhibition was evaluated using one-way analysis of variance with Tukey's post hoc test. The effect of OL on miR-181b, miR-137, miR-153 and Let-7d expression was assessed using quantitative reverse transcription polymerase chain reaction. Fold differences in expression between untreated, OL or OL + TMZ-treated samples were calculated using 2(-Delta Ct) method. Significance was evaluated using an independent sample t-test. Treatment with 277.5 and 555 mu M OL resulted in 39.51% and 75.40% reductions in T98G cells within 24 h. Coadministration of 325 mu M TMZ and 277.5 or 555 mu M, OL caused 2.08- and 2.83-fold increases, respectively, in the therapeutic effect of TMZ. OL + TMZ significantly increased microRNA expression, particularly Let-7d, than OLE. In conclusion, OL has an antitumour effect on GBM cells mainly via regulation of Let-7d expression. The present results also indicate other minor compounds in OLE play important anticancer roles.