Fibromatozisin klinikopatolojik değerlendirilmesi: 125 olgudan oluşan bir seri
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Date
2016-04-07
Authors
Altıntaş, Emine Kıyım
Journal Title
Journal ISSN
Volume Title
Publisher
Uludağ Üniversitesi
Abstract
Bu çalışmada fibromatozis tanısı almış olguların dağılımı ve patolojik özelliklerinin değerlendirilmesi amaçlanmıştır. Bu çalışma, retrospektif kesitsel bir araştırmadır. Bu araştırmada, Ocak 2005 tarihi ile Aralık 2011 tarihleri arasında Uludağ Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı’nda fibromatozis tanısı almış 125 olgu değerlendirilmiştir. Hastaların yaş, cinsiyet, tümör lokalizasyonu, tümör çapı ve rekürrens bilgileri tıbbi dosyalarından ve patoloji kayıtlarından elde edilmiştir. Yüzeyel fibromatozislerin 84’ü palmar, 6’sı plantar, derin fibromatozislerin ise 25’si ekstraabdominal, 6’sı abdominal, 4’ü intraabdominal fibromatozis olgusundan oluşmaktadır. Tüm hastaların yaş ortalaması 50.4±17.4 yıldır. Palmar fibromatozisli 84 olgunun 43’ü 5. ve 6. dekatlarda saptanmıştır. Derin fibromatozisli olguların yaş ortalaması 34.2±14.9’dır. Yüzeyel fibromatozislerde ortalama tümör çapı 3.4±1.5 cm iken derin fibromatozislerde 8.8±5.4 cm ölçülmüştür. Rekürrens oranı palmar fibromatozisli olgularda %14.3, plantar fibromatozisli olgularda %20, derin yerleşimli olgularda %25.7 olarak bulunmuştur. Çalışmamızda olgu serimizin epidemiyolojik ve klinikopatolojik özellikleri genel olarak literatür ile uyumlu bulunmuştur. Yüzeyel fibromatozis olgularında diabetin, derin fibromatozisde ise travmanın sıklıkla karşılaşılan komorbiditeler olduğu görülmüştür. Serimizdeki takip süresinin (7 yıl) kısa olmasına rağmen, rekürrense sık rastlanıldığı ve özellikle derin fibromatozis nedeniyle cerrahi geçirenlerde daha fazla olduğu saptanmıştır.
The aim of this study was to assess clinical characteristics and pathological features of patients diagnosed with fibromatosis. This study was a retrospective cohort study. Hematoxylin-eosin stained sections of materials of 125 cases with diagnosis of fibromatosis were reassessed. Medical records and pathology reports of patients were evaluated according to patients’ age, gender, tumor localization, tumor diameter and reccurence. In superficial fibromatoses, 84 cases were at palmar and 6 cases were at plantar localization. Furthermore, in deep fibromatoses, 6 cases were at abdominal, 4 were at intraabdominal, and 25 were at extraabdominal localization. The mean age of the patients was 50.4±17.4 years. Eighty (64%) of the cases were male and 45 (36%) were female. Male-to-female ratio was 1.7. Mean tumor diameter in superficial fibromatosis was significantly smaller than patients with deep fibromatosis (3.4±1.5 vs. 8.8±5.4 cm). Recurrence rate was higher 14,3% in cases with deep fibromatosis compared to superficial fibromatosis (25.7% vs. 38 14.4%). Our series demonstrated the similar epidemiologic and clinicopathologic features with the literatüre. We determined that diabetes and trauma are frequent comorbidites for superficial and deep fibromatosis in our series. Although, follow-up period (7 years) was short, recurrence rate was high, particularly in deep fibromatoses.
The aim of this study was to assess clinical characteristics and pathological features of patients diagnosed with fibromatosis. This study was a retrospective cohort study. Hematoxylin-eosin stained sections of materials of 125 cases with diagnosis of fibromatosis were reassessed. Medical records and pathology reports of patients were evaluated according to patients’ age, gender, tumor localization, tumor diameter and reccurence. In superficial fibromatoses, 84 cases were at palmar and 6 cases were at plantar localization. Furthermore, in deep fibromatoses, 6 cases were at abdominal, 4 were at intraabdominal, and 25 were at extraabdominal localization. The mean age of the patients was 50.4±17.4 years. Eighty (64%) of the cases were male and 45 (36%) were female. Male-to-female ratio was 1.7. Mean tumor diameter in superficial fibromatosis was significantly smaller than patients with deep fibromatosis (3.4±1.5 vs. 8.8±5.4 cm). Recurrence rate was higher 14,3% in cases with deep fibromatosis compared to superficial fibromatosis (25.7% vs. 38 14.4%). Our series demonstrated the similar epidemiologic and clinicopathologic features with the literatüre. We determined that diabetes and trauma are frequent comorbidites for superficial and deep fibromatosis in our series. Although, follow-up period (7 years) was short, recurrence rate was high, particularly in deep fibromatoses.
Description
Keywords
Palmar fibromatozis, Plantar fibromatozis, Desmoid tümör, Palmar fibromatosis, Plantar fibromatosis, Desmoid tumor
Citation
Altıntaş, E.K. vd. (2016). “Fibromatozisin klinikopatolojik değerlendirilmesi: 125 olgudan oluşan bir seri”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 42(1), 13-18.