Plasma prohepcidin levels in patients with chronic viral hepatitis: Relationship with liver fibrosis

Simple item page
dc.contributor.authorYılmaz, Yusuf
dc.contributor.buuauthorÖlmez, Ömer Fatih
dc.contributor.buuauthorGürel, Selim
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.scopusid26435400000tr_TR
dc.contributor.scopusid7003706434tr_TR
dc.date.accessioned2022-03-28T07:18:18Z
dc.date.available2022-03-28T07:18:18Z
dc.date.issued2010-04
dc.description.abstractObjectives Iron is deemed to play a crucial role in the pathophysiology of liver damage in patients with chronic viral hepatitis. Hepcidin has recently emerged as the key hormone in the regulation of iron balance and recycling. We assessed plasma prohepcidin levels in patients with chronic viral hepatitis and investigated the association of this molecule with iron parameters, histologic activity index, and liver fibrosis scores. Methods We enrolled 35 patients with chronic hepatitis C, 27 with chronic hepatitis B, and 21 healthy controls. Plasma levels of prohepcidin were measured by enzyme-linked immunosorbent assay. Results Mean prohepcidin levels were significantly lower in patients with chronic hepatitis B than in those with chronic hepatitis C (P < 0.001) and healthy comparison controls (P < 0.05). In patients with chronic hepatitis C, prohepcidin was independently associated with liver fibrosis scores (beta = -0.009, standard error = 0.003, P < 0.05). No association of prohepcidin with iron parameters was found. Conclusion Significantly lower prohepcidin levels are frequently found in patients with chronic hepatitis B. Levels of this molecule may represent a biochemical correlate of fibrosis in chronic hepatitis C virus infection.en_US
dc.identifier.citationÖlmez, Ö. F. vd. (2010). "Plasma prohepcidin levels in patients with chronic viral hepatitis: Relationship with liver fibrosis". European Journal of Gastroenterology and Hepatology, 22(4), 461-465.en_US
dc.identifier.endpage465tr_TR
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.issue4tr_TR
dc.identifier.pubmed19940783tr_TR
dc.identifier.scopus2-s2.0-77949439229tr_TR
dc.identifier.startpage461tr_TR
dc.identifier.urihttps://doi.org/10.1097/MEG.0b013e3283344708
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/19940783/
dc.identifier.urihttp://hdl.handle.net/11452/25370
dc.identifier.volume22tr_TR
dc.identifier.wos000276566100012tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.journalEuropean Journal of Gastroenterology and Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic hepatitis Ben_US
dc.subjectChronic hepatitis Cen_US
dc.subjectHistopathologyen_US
dc.subjectIronen_US
dc.subjectProhepcidinen_US
dc.subjectIron storesen_US
dc.subjectExpressionen_US
dc.subjectInfectionen_US
dc.subjectGastroenterology & hepatologyen_US
dc.subject.emtreeHepcidinen_US
dc.subject.emtreeProhepcidinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease associationen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHepatitis Ben_US
dc.subject.emtreeHepatitis Cen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeIron binding capacityen_US
dc.subject.emtreeLiver biopsyen_US
dc.subject.emtreeLiver fibrosisen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeScoring systemen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntimicrobial cationic peptidesen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B, chronicen_US
dc.subject.meshHepatitis C, chronicen_US
dc.subject.meshHumansen_US
dc.subject.meshIronen_US
dc.subject.meshLiver cirrhosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshProtein precursorsen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusHepcidins; Metal Transporting Protein 1; Iron-Refractory Iron Deficiency Anemiaen_US
dc.subject.wosGastroenterology & hepatologyen_US
dc.titlePlasma prohepcidin levels in patients with chronic viral hepatitis: Relationship with liver fibrosisen_US
dc.typeArticle
dc.wos.quartileQ3en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
PubMed
Scopus