Immunohistochemical and zymographical expressions of matrix metalloproteinase-2 (mmp-2) and matrix metalloproteinase-9 (mmp-9) in bovine papillomatous digital dermatitis

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dc.contributor.buuauthorAkkoç, Ahmet
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.contributor.orcid0000-0002-5090-7917tr_TR
dc.date.accessioned2020-12-22T10:45:34Z
dc.date.available2020-12-22T10:45:34Z
dc.date.issued2019-11-10
dc.description.abstractBovine digital dermatitis (BDD) is an important health issue of dairy cattle. Painful papillomatous tissue proliferations are observed in hind feet of affected animals. The pathogenesis of this papillomatous lesion in BDD is still poorly understood. Matrix metalloproteinases are a group of enzymes for tissue remodeling in both health and disease. In the submitted study, immune expressions of MMP-2 and MMP-9 enzymes and their zymographic activities were evaluated. Skin samples were obtained from 10 healthy and 10 dairy Holstein frisean cattle from local slaughterhouse. Higher immune staining of MMP-2 and MMP-9 were found in BDD samples when compared with healthy skin samples. The differences observed in MMP-2 and MMP-9 staining intensity and distributions were statistically significant (p< 0.05, p<0.05 respectively). Zymographic analyses revealed skin samples from both healthy and affected animals had pro-active and active forms of MMP2 and MMP-9 enzymes. Immunohistochemistry results indicate that significant increase in MMP-2 and MMP-9 enzymes in BDD samples. These results suggest MMP-2 and MMP-9 might have roles in the pathogenesis of BDDen_US
dc.identifier.citationAkkoç, A. (2019). "Immunohistochemical and zymographical expressions of matrix metalloproteinase-2 (mmp-2) and matrix metalloproteinase-9 (mmp-9) in bovine papillomatous digital dermatitis". Bursa Uludağ Üniversitesi Veteriner Fakültesi, 38(2), 83-87.tr_TR
dc.identifier.endpage87tr_TR
dc.identifier.issn1301-3173
dc.identifier.issue2tr_TR
dc.identifier.startpage83tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/891640
dc.identifier.urihttp://hdl.handle.net/11452/14550
dc.identifier.volume38tr_TR
dc.language.isoenen_US
dc.publisherBursa Uludağ Üniversitesitr_TR
dc.relation.journalVeteriner Hekimlikte Araştırma Dergisi / Journal of Research in Veterinary Medicinetr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBovine digital dermatitisen_US
dc.subjectMatrix metalloproteinasesen_US
dc.subjectImmunohistochemistryen_US
dc.subjectZymographyen_US
dc.titleImmunohistochemical and zymographical expressions of matrix metalloproteinase-2 (mmp-2) and matrix metalloproteinase-9 (mmp-9) in bovine papillomatous digital dermatitisen_US
dc.typeArticleen_US

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2019 Cilt 38 Sayı 2