Nail psoriasis successfully treated with intralesional methotrexate: Case report

dc.contributor.buuauthorSarıcaoğlu, Hayriye
dc.contributor.buuauthorÖz, Arife
dc.contributor.buuauthorTuran, Hakan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid6603722836tr_TR
dc.contributor.scopusid36982149700tr_TR
dc.contributor.scopusid16835681500tr_TR
dc.date.accessioned2021-12-23T09:23:06Z
dc.date.available2021-12-23T09:23:06Z
dc.date.issued2011
dc.description.abstractPsoriasis is a common, chronic disease which affects nearly 3% of the population. The lifetime incidence of nail involvement increases up to 80-90% for psoriatic patients. Nail psoriasis is considered a significant social problem. Many topical agents have been used for psoriatic nails with various side effects and some benefits; management is currently inconclusive. Methotrexate (MTX) is a folic acid analog, which irreversibly binds to dehydrofolate reductase and blocks deoxyribonucleic acid synthesis. It is considered a potential treatment option for rapidly growing cells and has an anti-inflammatory effect through inhibition of the polyamine pathway in autoimmune diseases. Intralesional MTX has been used successfully for various indications. We present a case successfully treated with low-dose intralesional MTX with no observed side effects in a 26-year-old female psoriatic patient suffering from nail dystrophy. In contrast, conventional topical and systemic therapies have various side effects, which limit their use. We conclude that intralesional MTX injection seems to be a safe and effective treatment option for nail psoriasis; however, large controlled studies are needed.en_US
dc.identifier.citationSarıcaoğlu, H. vd. (2011). "Nail psoriasis successfully treated with intralesional methotrexate: Case report". Dermatology, 222(1), 5-7.en_US
dc.identifier.endpage7tr_TR
dc.identifier.issn1018-8665
dc.identifier.issn1421-9832
dc.identifier.issue1tr_TR
dc.identifier.pubmed21228554tr_TR
dc.identifier.scopus2-s2.0-79951678241tr_TR
dc.identifier.startpage5tr_TR
dc.identifier.urihttps://doi.org/10.1159/000323004
dc.identifier.urihttps://www.karger.com/Article/Fulltext/323004
dc.identifier.urihttp://hdl.handle.net/11452/23497
dc.identifier.volume222tr_TR
dc.identifier.wos000287470100003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.journalDermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDermatologyen_US
dc.subjectNail psoriasisen_US
dc.subjectIntralesional methotrexateen_US
dc.subjectOf the literatureen_US
dc.subjectTherapyen_US
dc.subjectDiseaseen_US
dc.subject.emtreeMethotrexateen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeCase reporten_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug safetyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLow drug doseen_US
dc.subject.emtreeMedical historyen_US
dc.subject.emtreeNail diseaseen_US
dc.subject.emtreeNail dystrophyen_US
dc.subject.emtreeNail psoriasisen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreePsoriasisen_US
dc.subject.emtreeReviewen_US
dc.subject.meshAdulten_US
dc.subject.meshDermatologic agentsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, İntralesionalen_US
dc.subject.meshMethotrexateen_US
dc.subject.meshNailsen_US
dc.subject.meshPsoriasisen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.scopusOnycholysis; Nails; Pustulosis Palmoplantarisen_US
dc.subject.wosDermatologyen_US
dc.titleNail psoriasis successfully treated with intralesional methotrexate: Case reporten_US
dc.typeArticle
dc.wos.quartileQ2en_US

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