Prognostic significance of soft tissue deposits in laryngeal carcinoma

dc.contributor.authorAlpay, Melih
dc.contributor.buuauthorÖzmen, Ömer Afşin
dc.contributor.buuauthorSaraydaroğlu, Özlem
dc.contributor.buuauthorDemir, Uygar Levent
dc.contributor.buuauthorKasapoğlu, Fikret
dc.contributor.buuauthorCoşkun, Hamdi Hakan
dc.contributor.buuauthorBasut, Oğuz Ibrahim
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9698-0546tr_TR
dc.contributor.researcheridAAH-9701-2021tr_TR
dc.contributor.researcheridA-1452-2019tr_TR
dc.contributor.researcheridAAI-3877-2021tr_TR
dc.contributor.scopusid55407733900tr_TR
dc.contributor.scopusid15074395500tr_TR
dc.contributor.scopusid56868421800tr_TR
dc.contributor.scopusid56254721200tr_TR
dc.contributor.scopusid13610800100tr_TR
dc.contributor.scopusid6602318367tr_TR
dc.date.accessioned2023-09-26T08:49:27Z
dc.date.available2023-09-26T08:49:27Z
dc.date.issued2017-07-02
dc.description.abstractIntroduction: Soft tissue deposits is tumorous islands apart from lymph nodes and occasionally diagnosed in neck dissection specimens. Their importance has begun to be recognized, however, their value has not been investigated in laryngeal cancer as a single tumor site. Objective: To investigate the prognostic value of soft tissue deposits in patients with laryngeal carcinoma. Methods: Medical records of 194 patients with laryngeal carcinoma who were treated primarily by surgery and neck dissection were reviewed. Prognostic significance of soft tissue deposits was assessed along with other clinical and pathological findings. Recurrence rates, overall and disease-specific survival rates were examined. Results: The incidence of soft tissue deposits was found to be 7.2% in laryngeal carcinoma. N stage was more advanced in patients who had soft tissue deposits. Regional recurrence rate was higher and disease specific and overall survivals rates were significantly lower in patients with soft tissue deposits in univariate analysis. However, in multivariate analysis, soft tissue deposits were not found as an independent risk factor. Conclusion: In laryngeal carcinoma, soft tissue deposits was diagnosed in patients with more advanced neck disease and their significance was lesser than other factors including extranodal extension.en_US
dc.description.abstractResumo Introdução: Depósitos de tecido mole são ilhas tumorais diferente dos linfonodos e ocasionalmente diagnosticados em amostras de esvaziamento cervical. Sua importância começou a ser reconhecida, mas seu valor não foi investigado no câncer de laringe como um único local de tumor. Objetivo: Investigar o valor prognóstico do depósito de tecido mole em pacientes com carcinoma laríngeo. Método: Os prontuários de 194 pacientes com carcinoma laríngeo tratados principalmente por cirurgia e esvaziamento cervical foram analisados. O significado prognóstico dos depósitos de tecido mole foi avaliado juntamente com outros achados clínicos e histopatológicos. As taxas de recidiva, as taxas de sobrevida geral e específicas da doença foram avaliadas. Resultados: Observou-se uma incidência de depósitos de tecido mole de 7,2% no carcinoma laríngeo. O estágio N foi mais avançado em pacientes com depósitos de tecido mole. A taxa de recorrência regional foi maior e as taxas de sobrevida geral e específica da doença foram significativamente menores nesses pacientes na análise univariada. No entanto, na análise multivariada, o depósito de tecido mole não foi observado como um fator de risco independente. Conclusão: No carcinoma laríngeo, o depósito de tecido mole foi diagnosticado em pacientes com doença cervical mais avançada, mas sua significância foi menor do que outros fatores, inclusive a extensão extranodal.fre
dc.identifier.citationÖzmen, Ö. A. vd. (2018). ''Prognostic significance of soft tissue deposits in laryngeal carcinoma''. Brazilian Journal of Otorhinolaryngology, 84(5), 566-573.en_US
dc.identifier.endpage573tr_TR
dc.identifier.issn1808-8694
dc.identifier.issn1808-8686
dc.identifier.issue5tr_TR
dc.identifier.pubmed28823696tr_TR
dc.identifier.scopus2-s2.0-85027470033tr_TR
dc.identifier.startpage566tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.bjorl.2017.07.002
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1808869417301167
dc.identifier.urihttp://hdl.handle.net/11452/34052
dc.identifier.volume84tr_TR
dc.identifier.wos000446305300007tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAssoc Bsarileira Otorrinolaringologia & Cirurgia Cervicofacialen_US
dc.relation.collaborationSanayitr_TR
dc.relation.journalBrazilian Journal of Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOtorhinolaryngologyen_US
dc.subjectLaryngeal canceren_US
dc.subjectSoft tissue depositen_US
dc.subjectCervical metastasisen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.subjectSquamous-cell carcinomaen_US
dc.subjectExtracapsular spreaden_US
dc.subjectPerineural invasionen_US
dc.subjectCanceren_US
dc.subjectHeaden_US
dc.subjectMetastasesen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer prognosisen_US
dc.subject.emtreeCancer recurrenceen_US
dc.subject.emtreeCancer survivalen_US
dc.subject.emtreeDisease specific survivalen_US
dc.subject.emtreeDistant metastasisen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeLarynx carcinomaen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNeck dissectionen_US
dc.subject.emtreeOverall survivalen_US
dc.subject.emtreePeroperative complicationen_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.emtreeSecond canceren_US
dc.subject.emtreeSmokingen_US
dc.subject.emtreeSoft tissue canceren_US
dc.subject.emtreeSoft tissue depositen_US
dc.subject.emtreeSurgical marginen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeBrazilen_US
dc.subject.emtreeEpidemiologyen_US
dc.subject.emtreeLarynx tumoren_US
dc.subject.emtreeLymph node metastasisen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMortalityen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeSecondaryen_US
dc.subject.emtreeSoft tissue tumoren_US
dc.subject.emtreeSquamous cell carcinomaen_US
dc.subject.emtreeSurvival rateen_US
dc.subject.emtreeVery elderlyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshBrazilen_US
dc.subject.meshCarcinoma, squamous cellen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLaryngeal neoplasmsen_US
dc.subject.meshLymphatic metastasisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeck dissectionen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshSoft tissue neoplasmsen_US
dc.subject.meshSurvival rateen_US
dc.subject.scopusNeck Dissection; Squamous Cell Carcinoma Of Head And Neck; Sentinel Lymph Node Biopsyen_US
dc.subject.wosOtorhinolaryngologyen_US
dc.titlePrognostic significance of soft tissue deposits in laryngeal carcinomaen_US
dc.title.alternativeImportância prognóstica de depósitos de tecido mole no carcinoma laríngeofre
dc.typeArticle
dc.wos.quartileQ2en_US

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